Position of mutation on reference sequence inferred by FlyBase curator based on author statement: Deletion of 33 nucleotides associated with an insertion of 13 nucleotides, 370 amino acids downstream from the start of translation. Leads to premature stop codon.
Deletion of 33 nucleotides associated with an insertion of 13 nucleotides, 370 amino acids downstream from the start of translation. This causes a frameshift mutation and premature stop codon within the coding region.
m1, tynPG38 double mutants have denticles with thin extremities (as found in tynPG38 single mutants) and lacking the medial constriction (as found in m1 single mutants). The addition of Df(3L)zyeex72, which deletes zye, has a further effect, leading to denticles with a twisted appearence.
The denticles of m1, sn3 mutants show splitting in addition to the defects seen in either single mutant. m1, f36a mutants also show denticle splitting. sn3, m1, f36a triple mutants have small, highly misshapen denticles that are more affected than those of m1, f36a or m1, sn3 double mutants. sn3, m1, f36a; shaV15 and sn3, m1, f36a; WASp3 quadruple mutants show further impairment to denticle formation compared to sn3, m1, f36a triple mutants, with mutants exhibiting regions of naked cuticle where denticles lie in wild-type animals.
The dorsal hairs on the abdominal segments of sn3, m1, f36a triple mutants are severly reduced in size, and in some cases, hairs are abrogated leaving abnormal naked regions. This phenotype is more severe in sn3, m1, f36a; WASp3 quadruple mutants and is even more severe in sn3, m1, f36a; shaV15 mutants in which most dorsal hairs are absent, leaving naked cuticle.
Morgan, Aug. 1910.