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General Information
Symbol
Dmel\RpL36B46
Species
D. melanogaster
Name
FlyBase ID
FBal0011883
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Point mutant.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Shows a dominant Minute phenotype: short fine bristles, delayed development and reduced viability. embryos have run-associated segmentation defects. This phenotype is suppressed by the maternal presence of P{1BD#1}. Reduced maternal RpL36 activity increases the penetrance and severity of the segmental defects observed in larvae heterozygous for Kr or kni mutations. Reduced maternal RpL36 activity has no effect on the larval or adult phenotypes of twi or Dl heterozygotes, or on the viability of Kr heterozygotes.

Lethal phase is from early larval to the pupal stage.

Recovered by Voelker in a screen for lethals in the vicinity of su(s). Lethality occurs between the first larval instar and pupation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

RpL36B46 is an enhancer of phenotype of run3

Additional Comments
Genetic Interactions
Statement
Reference

Acts as a dosage sensitive maternal modifier of run : causes tergite defects in greater than 65% of run3 heterozygotes. When derived from RpL36B46/+ females, 57% of heterozygous run embryos have run-associated segmentation defects. Reduced maternal RpL36 activity increases the penetrance and severity of the segmental defects observed in larvae heterozygous for Kr or kni mutations. Reduced maternal RpL36 activity has no effect on the larval or adult phenotypes of twi or Dl heterozygotes, or on the viability of Kr heterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Maternally supplied RpL36+t10 rescues the dominant Minute phenotype of RpL36B46 and its effects in heterozygous run mutant embryos.

Lethality is rescued by RpL36+t10.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
RpL36B46
Name Synonyms
Secondary FlyBase IDs
    References (4)