Allele Dmel\M(2)24F¹

General Information
Symbol	Dmel\M(2)24F¹	Species	D. melanogaster
Name		FlyBase ID	FBal0011887
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\M(2)24F

Allele class
Mutagen	spontaneous
Nature of the Allele
Allele class
Mutagen	spontaneous
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	visible \| dominant (Dunn and Mossige, 1937) small body \| larval stage (Sigrist et al., 2000) Minute \| dominant (Dunn and Mossige, 1937) developmental rate defective \| dominant \| larval stage (Dunn and Mossige, 1937)
Phenotype Manifest In
	macrochaeta (Dunn and Mossige, 1937) eye (Dunn and Mossige, 1937)
Detailed Description
	Statement Reference RK2. Heterozygotes have a Minute bristle phenotype and appreciably larger and rougher eyes than normal. Larval development of heterozygotes is delayed by about 1.2 days at 25^oC compared to control siblings. (Dunn and Mossige, 1937) Mutants show a significant developmental delay and somewhat smaller larval body sizes than normal, but no obvious morphological neuromuscular junction phenotypes. (Sigrist et al., 2000)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference Dl[+]/Dl¹, M(2)24F¹ has lethal \| dominant phenotype (Schultz, 1929) J¹/J[+], M(2)24F¹ has lethal \| dominant phenotype (Schultz, 1929) J¹, M(2)24F¹/M(2)24F[+] has lethal \| dominant phenotype (Schultz, 1929) L²/L[+], M(2)24F¹ has lethal \| dominant phenotype (Dunn and Mossige, 1937) L², M(2)24F¹/M(2)24F[+] has lethal \| dominant phenotype (Dunn and Mossige, 1937) Dl¹, M(2)24F¹ has lethal \| dominant phenotype (Schultz, 1929)
Phenotype Manifest In
NOT Enhanced by
Statement Reference M(2)24F¹ has phenotype, non-enhanceable by M(2)31A¹ (Schultz, 1929) M(2)24F¹ has phenotype, non-enhanceable by M(2)28¹ (Schultz, 1929) M(2)24F¹ has phenotype, non-enhanceable by M(3)69E¹ (Schultz, 1929)
NOT suppressed by
Statement Reference M(2)24F¹ has phenotype, non-suppressible by M(2)31A¹ (Schultz, 1929) M(2)24F¹ has phenotype, non-suppressible by M(2)28¹ (Schultz, 1929) M(2)24F¹ has phenotype, non-suppressible by M(3)69E¹ (Schultz, 1929)
Enhancer of
Statement Reference M(2)24F¹/M(2)24F[+] is an enhancer of phenotype of J¹ (Schultz, 1929)
NOT Enhancer of
Statement Reference M(2)24F¹ is a non-enhancer of phenotype of M(2)31A¹ (Schultz, 1929) M(2)24F¹ is a non-enhancer of phenotype of M(2)28¹ (Schultz, 1929) M(2)24F¹ is a non-enhancer of phenotype of M(3)69E¹ (Schultz, 1929)
NOT Suppressor of
Statement Reference M(2)24F¹ is a non-suppressor of phenotype of M(2)31A¹ (Schultz, 1929) M(2)24F¹ is a non-suppressor of phenotype of M(2)28¹ (Schultz, 1929) M(2)24F¹ is a non-suppressor of phenotype of M(3)69E¹ (Schultz, 1929)
Other
Statement Reference Dl[+]/Dl¹, M(2)24F¹ has leg phenotype (Schultz, 1929) Dl[+]/Dl¹, M(2)24F¹ has wing phenotype (Schultz, 1929) Dl[+]/Dl¹, M(2)24F¹ has wing vein phenotype (Schultz, 1929) Dl[+]/Dl¹, M(2)24F¹ has tarsal segment phenotype (Schultz, 1929) Dl[+]/Dl¹, M(2)24F¹ has femur phenotype (Schultz, 1929) Dl[+]/Dl¹, M(2)24F¹ has ocellus phenotype (Schultz, 1929) Dl[+]/Dl¹, M(2)24F¹ has macrochaeta phenotype (Schultz, 1929) Dl¹, M(2)24F¹ has leg phenotype (Schultz, 1929) Dl¹, M(2)24F¹ has wing phenotype (Schultz, 1929) Dl¹, M(2)24F¹ has wing vein phenotype (Schultz, 1929) Dl¹, M(2)24F¹ has tarsal segment phenotype (Schultz, 1929) Dl¹, M(2)24F¹ has femur phenotype (Schultz, 1929) Dl¹, M(2)24F¹ has ocellus phenotype (Schultz, 1929)
Additional Comments
Genetic Interactions
Statement Reference Dl¹ M(2)24F¹ double heterozygotes do not eclose, although many flies form pharate adults. These flies have many abnormalities, including shortening of the legs. The tarsus, which is primarily affected, is sometimes reduced to half the size of the tibia. The femur is bent like a bow. One pair of legs (usually the last pair) may be more affected than the others. The wings are often scalloped and have an extreme Dl mutant phenotype; showing both thickening at the crossveins and deltas at the wing margin. The texture of the wing is very brittle. The eye are very rough or may be reduced in size. The ocelli are sometimes fused or one of them may be missing. The bristles are larger than seen in the M(2)24F¹ single heterozygote and are often duplicated. Irregular additional hairs are seen on the thorax, as in Dl¹ single heterozygotes. (Schultz, 1929)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 5 )
Bloomington	347 M(2)24F¹/SM5 5697 w^*; M(2)24F¹ P{πM}36F P{neoFRT}40A/CyO
Kyoto	105864 M(2)24F¹/SM5 108374 w^*; M(2)24F¹ P{πM}36F P{neoFRT}40A/CyO 101545 M(2)24F¹ / SM5, al² Cy¹ lt^v cn² sp²
Notes on Origin
Discoverer	Schultz.

Comments
	Not suppressed by RpL32^+t3.3. (Kongsuwan et al., 1985)
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	M (Garoia et al., 2000) M(2)24F-1 (Sigrist et al., 2000) M(2)24F¹ M(2)z (Barrio and de Celis, 2004, Garoia et al., 2000, Roy et al., 1984, Reuter and Szidonya, 1983, Roberts and Broderick, 1982, Broderick and Roberts, 1982, ) M(2)Z (Kongsuwan et al., 1985) M_z (Schultz, 1929) Mz (Dunn and Mossige, 1937)
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Barrio and de Celis, 2004, Proc. Natl. Acad. Sci. USA 101(16): 6021--6026 Regulation of spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway. [FBrf0175094] Garoia et al., 2000, Mech. Dev. 94(1-2): 95--109 Cell behaviour of Drosophila fat cadherin mutations in wing development. [FBrf0128473] Sigrist et al., 2000, Nature 405(6790): 1062--1065 Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. [FBrf0128816] Kongsuwan et al., 1985, Nature 317(6037): 555--558 A Drosophila Minute gene encodes a ribosomal protein. [FBrf0043337] Roy et al., 1984, J. Biosci., Bangalore 6: 87--95 Genetic analysis of a Minute mutation in the distal region of the second chromosome of Drosophila melanogaster. [FBrf0063845] Reuter and Szidonya, 1983, Chromosoma 88: 277--285 Cytogenetic analysis of variegation suppressors and a dominant temperature-sensitive lethal in region 23-26 of chromosome arm 2L in Drosophila melanogaster. [FBrf0039034] Broderick and Roberts, 1982, Genetics 102: 71--74 Localization of Minutes to specific polytene chromosome bands by means of overlapping duplications. [FBrf0038070] Roberts and Broderick, 1982, Genetics 102: 75--89 Properties and evolutionary potential of newly induced tandem duplications in Drosophila melanogaster. [FBrf0038073] Dunn and Mossige, 1937, Hereditas 23: 70--90 The effects of the Minute mutations of Drosophila melanogaster on developmental rate. [FBrf0003920] Schultz, 1929, Genetics 14: 366--419 The Minute reaction in the development of Drosophila melanogaster. [FBrf0001812]

Allele Dmel\M(2)24F1

Allele Dmel\M(2)24F¹