FB2025_01 , released February 20, 2025
Allele: Dmel\RpS3A57g
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General Information
Symbol
Dmel\RpS3A57g
Species
D. melanogaster
Name
FlyBase ID
FBal0011966
Feature type
allele
Associated gene
Dmel\RpS3A
Associated Insertion(s)
Doc{}RpS3A57g
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Hochman, 1976, Hochman, 1974, Hochman, 1971)
Progenitor genotype
Associated Insertion(s)
Doc{}RpS3A57g
Cytology

Polytene chromosomes normal.

Description

Insertion of a 4.7kb Doc element in the promoter region, 85bp upstream of the transcription start site. The direction of transcription of the Doc open reading frame is opposite to that of the direction of transcription of RpS3A. An 8bp duplication (AAGCGATA) is present at the site of insertion of the Doc element.

(Kronhamn and Rasmuson-Lestander, 1999)

Coding sequence is intact in RpS3A57g.

(Locke et al., 1999)

Insertion of a Doc element 43bp upstream of the TATA box.

(van Beest et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  intrinsic cardiomyopathy
      CEA
      (Casad et al., 2011)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous RpS3A57g mutant females exhibit a dilated cardiomyopathy phenotype, including an increased end-systolic dimension (EDD) and a decreased fractional shortening (FS) compared to controls. Bristles appear short and thin compared to wild type (Minute phenotype).

      (Casad et al., 2011)

      Flies are delayed in eclosion by 12.1 +/- 1.5 hours compared to wild type flies.

      (Kronhamn and Rasmuson-Lestander, 1999)

      Heterozygotes have shorter bristles than wild type flies. Eclosion is delayed by 33 hours.

      (Ferrus, 1975)

      Medium Minute; viability good; development protracted; eclosion delayed 33 hr (Ferrus, 1975). RpS3A/+/+ triplo-fours are non-Minute (Mohr, 1933). Homozygous mutants homozygous embryonic lethal (Farnsworth, 1951). RK2.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      RpS3A[+]/RpS3A57g is an enhancer of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

      (Coelho et al., 2005)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      RpS3A[+]/RpS3A57g is an enhancer of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

      (Coelho et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Fails to uncover mutations in neighboring loci.

      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (15)