P2322L | mei-41-PA
The amino acid change is reported relative to GB:U34925 (in which the predicted CDS is missing 163 N-terminal amino acids relative to genome release 3.2). Other amino acid changes common to several mei-41 mutants are also present in the strain.
Amino acid replacement: P2159L.
In addition to the P2159L amino acid replacement, which may cause the mutant phenotype, a number of additional amino acid changes are present compared to the U34925 mei-41 GenBank sequence (these "common" mutations are also present in other mei-41 mutant alleles, possibly due to variability present in the mutagenised population).
Nucleotide substitution: C8924T.
If mei-41D3/mei-41D5 females are also heterozygous for grpfsA4, the hatch rates are reduced to 1% and 23% at 25oC and 20oC respectively. The lethality of embryos derived from mei-41D3/mei-41D5 females is partly rescued if the females are also heterozygous for either CycAunspecified or CycBunspecified, and greater rescue is seen if the females are also heterozygous for both CycAunspecified and CycBunspecified.