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General Information
Symbol
Dmel\mei-41D15
Species
D. melanogaster
Name
FlyBase ID
FBal0012166
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

A16394319C

Reported nucleotide change:

A4328C

Amino acid change:

T815P | mei-41-PA

Reported amino acid change:

T652P

Comment:

The mutation site reported in FBrf0160718 is relative to GB:U34925 (in which the predicted CDS is missing 163 N-terminal amino acids relative to genome release 3.2). Other amino acid changes common to several mei-41 mutants are also present in the strain (see FBrf0160718).

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: T652P.

In addition to the T652P amino acid replacement, which may cause the mutant phenotype, a number of additional amino acid changes are present compared to the U34925 mei-41 GenBank sequence (these "common" mutations are also present in other mei-41 mutant alleles, possibly due to variability present in the mutagenised population).

Nucleotide substitution: A4328C.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

84% of eggs derived from homozygous females hatch into larvae. Hemizygous larvae show a G2/M checkpoint that is robust as in wild-type.

Hemizygous male larvae are not sensitive to HN2. They are sensitive to 0.08% MMS but relatively insensitive to 0.04% MMS.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
mei-41D15
mus(1)104D2
mus104D2
Name Synonyms
Secondary FlyBase IDs
    References (3)