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General Information
Symbol
Dmel\mei-41D18
Species
D. melanogaster
Name
FlyBase ID
FBal0012169
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Precocious anaphase is seen in homozygous mei-217r1 or mei-217g10 mature oocytes. In mei-217r1 mei-41D18 or mei-217g10 mei-41D18 double mutants a metaphase arrest is almost always seen in mature oocytes (as occurs in wild type).

No precocious anaphases are seen in mutant oocyte nuclei. In the progeny of homozygous mei-41D18 mothers, there is a high frequency of nullo-X gametes compared to diplo-X gametes.

Eggs are laid.

Hemizygous male larvae are sensitive to HN2 and MMS.

Homozygous females lay eggs that fail to hatch.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

mei-41D18 has phenotype, suppressible | partially by mei-P22P22

NOT suppressed by
Statement
Reference

mei-41D18 has phenotype, non-suppressible by mei-2181

mei-41D18 has phenotype, non-suppressible by mei-9a

Suppressor of
Statement
Reference

mei-41D18 is a suppressor of meiosis I | female phenotype of mei-217g10

mei-41D18 is a suppressor of meiosis I | female phenotype of mei-217r1

Other
Statement
Reference

mei-41D18, mei-9a has oocyte nucleus & meiotic cell cycle phenotype

mei-41D18, mei-P22P22 has oocyte nucleus & meiotic cell cycle phenotype

c(3)G68, mei-41D18 has oocyte nucleus & meiotic cell cycle phenotype

mei-41[+]/mei-41D18, mei-9a has oocyte nucleus & meiotic cell cycle phenotype

Additional Comments
Genetic Interactions
Statement
Reference

About a quarter of nuclei in mei-9a/mei-9a; mei-41D18/+ oocytes exhibit premature anaphase (or later) meioses. In mei-41D18; mei-2181 oocytes no premature anaphases are seen. In mei-41D18; mei-P22P22 oocyte nuclei premature anaphases are seen. In mei-41D18; c(3)G68 oocyte nuclei premature anaphases are seen. The addition of homozygous mei-P22P22 partially suppresses the high frequency of nullo-X gametes compared to diplo-X gametes seen in the progeny of homozygous mei-41D18 mothers but the addition of homozygous mei-2181 or mei-9a does not.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

The semi-lethality of the "mei-41D18" chromosome may be due to mutations at other loci and not at mei-41, because mei-41D18 is viable in combination with other semi-lethal mei-41 mutant chromosomes.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
12-1007
fs(1)M3712-1007
mei-4112-1007
mei-41D18
Name Synonyms
Secondary FlyBase IDs
    References (7)