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General Information
Symbol
Dmel\mei-9D2
Species
D. melanogaster
Name
FlyBase ID
FBal0012177
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of nucleotides 553-558, resulting in an in frame deletion of two conserved residues (V143 and K144) at the beginning of helicase-like motif III.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

mei-9D2/mei-9A2 females show 29% X chromosome nondisjunction, compared to 0.33% in wild-type females. mei-9D2/mei-9A2 larvae are hypersensitive to ultraviolet light and nitrogen mustard.

Flies are sensitive to X rays.

Hemizygous male larvae are sensitive to HN2 and MMS. Homozygous females produce diplo-X and nullo-X exceptions at roughly the same frequency.

mutagen sensitive reduces exchange

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

The lesion in mei-9D2 and in mei-9D3 is identical.

Comments
Comments

Homozygotes have normal postreplication repair capabilities, but excision repair is reduced to undetectable levels. Homozygous cultured cells respond to UV irradiation with normal reductions in thymidine incorporation and with the synthesis of normal-length nascent DNA.

An endonuclease activity which is specific for partially depurinated DNA is reduced in extracts of mei-9D2 larval brain ganglia compared to wild-type.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
mei-9D2
Name Synonyms
Secondary FlyBase IDs
    References (7)