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General Information
Symbol
Dmel\mle5
Species
D. melanogaster
Name
FlyBase ID
FBal0012338
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
mleRoma
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion in mle.

2.5kb deletion.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

mle5/mle1 is a suppressor of ovary phenotype of ovoD1rv23

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Ovaries of homozygous ovoD1rv23 females contain germline chambers in less than 20% of cases. This phenotype is partially suppressed if the females are also carrying mle1/mle5. ovoD1rv23/ovoD1rv23; mle1/mle5 ovaries most often contain germ cells of male morphology rather than female morphology. This phenotype is partially suppressed by SxlM1; ovaries more often contain germ cells of female morphology rather than male morphology.

The survival of 2X ovoD1rv23/ovoD1rv22 germline cells is enhanced in an mle1/mle5 background. Surviving cells usually form small ovarian tumours.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Mutant phenotype can be rescued by P element mediated transformation of a wild type mle gene copy.

Allelism inferred from map position at 2-55.2.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)