• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Allele Dmel\mor¹

General Information
Symbol	Dmel\mor1	Species	D. melanogaster
Name		FlyBase ID	FBal0012411
Feature type	allele	Associated gene	Dmel\mor
Also Known As	moira1
Allele class	hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Gindhart and Kaufman, 1995)
Mutagen	ethyl methanesulfonate (Kennison and Tamkun, 1988)
Mutations Mapped to the Genome
Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	enhancer of variegation | dominant, with P{hsp26-pt-T}39C-5 (Boivin et al., 2003) enhancer of variegation | dominant, with P{hsp26-pt-T}39C-27 (Boivin et al., 2003) enhancer of variegation | dominant, with P{hsp26-pt-T}39C-31 (Boivin et al., 2003) lethal | recessive (Kennison and Tamkun, 1988) non-enhancer of variegation, with P{wA}4-4 (Boivin et al., 2003) non-suppressor of variegation, with P{wA}4-4 (Boivin et al., 2003) visible | somatic clone (Brizuela and Kennison, 1997)
Phenotype Manifest In
	cell | somatic clone (Collins et al., 1999) chorion | germline clone (Brizuela and Kennison, 1997) dorsal appendage | germline clone (Brizuela and Kennison, 1997) egg | germline clone (Brizuela and Kennison, 1997) femur | somatic clone (Brizuela and Kennison, 1997) haltere | somatic clone (Brizuela and Kennison, 1997) macrochaeta & haltere | posterior | somatic clone (Brizuela and Kennison, 1997) mesothoracic leg | somatic clone (Brizuela and Kennison, 1997) mesothoracic tarsal segment | somatic clone (Brizuela and Kennison, 1997) metathoracic leg | somatic clone (Brizuela and Kennison, 1997) prothoracic leg | anterior | somatic clone (Brizuela and Kennison, 1997) prothoracic leg | somatic clone (Brizuela and Kennison, 1997) sex comb | somatic clone (Brizuela and Kennison, 1997) tarsal segment | somatic clone (Brizuela and Kennison, 1997) tibia | somatic clone (Brizuela and Kennison, 1997) wing | posterior | somatic clone (Brizuela and Kennison, 1997) wing margin & macrochaeta | somatic clone (Brizuela and Kennison, 1997)
Detailed Description
	Statement Reference Heterozygotes have normal wings. (Curtis et al., 2011) Flies heterozygous for mor[1] show suppression of the Scer\GAL4[GMR.PS], Dref[Scer\UAS.cSa] severe rough eye phenotype; eyes are modestly rough and fused ommatidia are not apparent. (Nakamura et al., 2008) mor1/+ enhances the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5, P{hsp26-pt-T}39C-27 and P{hsp26-pt-T}39C-31. mor1/+ has no effect on the telomeric position effect (TPE) of P{wA}4-4. (Boivin et al., 2003) mor1 clones show a severe reduction in growth phenotype. (Collins et al., 1999) Homozygous clones in the haltere can give rise to wing structures; many clones in the posterior haltere differentiate large bristles characteristic of anterior wing margin. Clones induced early in development cause the haltere to be absent, small, or have a homeotic transformation. Clones induced later (48-72 hours after egg laying) show more extreme transformations of haltere to anterior wing structures than early clones. Homozygous clones in the posterior wing cause distortions in wing shape; venation is disrupted and large socketed bristles appear along the posterior wing margin. Homozygous clones in the leg cause the femur and tibia to be short and twisted, and the tarsal segments to be enlarged. Leg clones also contain extra bristles. Clones in the anterior first leg are transformed to anterior second leg or have extra sex comb teeth. Clones in the second leg are twisted, have vesicles of extra tissue, or cause the absence of the entire leg. Tarsal segments are often fused, duplicated or absent. Clones in the third leg often have partial or complete duplications of distal structures, or the entire leg morphology is abnormal. Clones in the first and third legs often cause truncations of the leg. Eggs derived from homozygous germ-line clones fail to hatch and are very abnormal. These abnormalities include collapsed eggs, eggs with partial or no chorions, small or abnormally shaped eggs and fused and thick dorsal appendages. (Brizuela and Kennison, 1997) Mutation changes the level of w expression in ph-plac+3 flies; eye colour is lighter. (Fauvarque et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference mor1 has visible | dominant phenotype, enhanceable by Bap60[+]/Bap601 (Moeller et al., 2005)
Enhancer of
Statement Reference mor[+]/mor1 is an enhancer of visible | dominant phenotype of Snr1E1 (Curtis et al., 2011) mor[+]/mor1 is an enhancer of visible phenotype of ct53d (Krupp et al., 2005) mor1 is an enhancer of eye color defective phenotype of w1118, wmC.ph-d.826 (Bloyer et al., 2003) mor1 is an enhancer of eye color defective phenotype of w1118, wmC.ph-p.418 (Bloyer et al., 2003) mor1 is an enhancer of eye color defective phenotype of w1118, wmC.ph-p.418bis (Bloyer et al., 2003) mor1 is an enhancer of eye color defective phenotype of w1118, wmC.ph-p.812 (Bloyer et al., 2003) mor1 is an enhancer of eye color defective phenotype of w1118, wmC.ph-p.813 (Bloyer et al., 2003) mor1 is an enhancer of eye color defective phenotype of w1118, wmC.ph-p.813bis (Bloyer et al., 2003) mor1 is an enhancer of eye color defective phenotype of wFab-7.5F24 (Cavalli, 1999) mor1 is an enhancer of eye color defective phenotype of wph-p.lac+3/w1118 (Bloyer et al., 2003) mor1 is an enhancer of eye color defective phenotype of wT81 (Netter et al., 1998) mor1 is an enhancer of visible | dominant phenotype of tna1 (Gutierrez et al., 2003) mor1 is an enhancer of visible phenotype of BacA\p35GMR.PH, DpGMR.PD, E2fGMR.PD (Staehling-Hampton et al., 1999)
NOT Enhancer of
Statement Reference mor1 is a non-enhancer of visible phenotype of BEAF-32Scer\UAS.cYa, Scer\GAL4GMR.PS (Yamaguchi et al., 2001)
Suppressor of
Statement Reference mor[+]/mor1 is a suppressor | partially of visible phenotype of ctK (Krupp et al., 2005) mor[+]/mor1 is a suppressor of increased cell death phenotype of DrefScer\UAS.cSa, Scer\GAL4GMR.PS (Hirose et al., 2001) mor[+]/mor1 is a suppressor of visible | homeotic phenotype of AntpNs, Pc2 (Kennison and Tamkun, 1988) mor1 is a suppressor of lethal phenotype of Ras85DV12.sev, sevS11.T:Hsap\MYC (Maixner et al., 1998) mor1 is a suppressor of visible | dominant | adult stage phenotype of Pc4 (Brizuela and Kennison, 1997) mor1 is a suppressor of visible | dominant | adult stage phenotype of Pcl10 (Brizuela and Kennison, 1997) mor1 is a suppressor of visible | dominant | homeotic phenotype of Pc4 (Brizuela and Kennison, 1997) mor1 is a suppressor of visible | dominant | homeotic phenotype of Pcl10 (Brizuela and Kennison, 1997) mor1 is a suppressor of visible | dominant phenotype of AntpNs (Brizuela and Kennison, 1997) mor1 is a suppressor of visible phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, dmScer\UAS.cZa (Secombe et al., 2007)
NOT Suppressor of
Statement Reference mor1 is a non-suppressor of visible phenotype of BEAF-32Scer\UAS.cYa, Scer\GAL4GMR.PS (Yamaguchi et al., 2001)
Other
Statement Reference brm2, mor1 has visible | dominant phenotype (Vazquez et al., 1999, Vazquez et al., 1999) corto[+]/corto420, mor1 has visible phenotype (Lopez et al., 2001) corto420, mor1 has visible phenotype (Lopez et al., 2001) HcfHR1, mor[+]/mor1 has visible phenotype (Rodriguez-Jato et al., 2011) Ras85DV12.sev, mor1, sevS11.T:Hsap\MYC has viable phenotype (Maixner et al., 1998, Maixner et al., 1998) Su(var)3-3[+]/Su(var)3-3ΔN, mor1 has visible | dominant phenotype (Curtis et al., 2011) γTub23CPl-2, mor1 has visible | dominant phenotype (Vázquez et al., 2008)
Phenotype Manifest In
Enhanced by
Statement Reference mor1 has humeral bristle phenotype, enhanceable by Bap60[+]/Bap601 (Moeller et al., 2005)
NOT Enhanced by
Statement Reference mor1 has phenotype, non-enhanceable by Alhunspecified (Perrin et al., 2003)
Suppressed by
Statement Reference mor1 has phenotype, suppressible by osa308 (Collins et al., 1999)
NOT suppressed by
Statement Reference mor1 has phenotype, non-suppressible by Alhunspecified (Perrin et al., 2003)
Enhancer of
Statement Reference mor[+]/mor1 is an enhancer of leg phenotype of e(y)34 (Chalkley et al., 2008) mor[+]/mor1 is an enhancer of wing phenotype of ct53d (Krupp et al., 2005) mor[+]/mor1 is an enhancer of wing vein | ectopic phenotype of net1 (Marenda et al., 2004) mor[+]/mor1 is an enhancer of wing vein | ectopic phenotype of Snr1E1 (Curtis et al., 2011) mor1 is an enhancer of eye phenotype of Scer\GAL4ey.PH, osaScer\UAS.cCa (Collins et al., 1999) mor1 is an enhancer of pigment cell phenotype of wFab-7.5F24 (Cavalli, 1999) mor1 is an enhancer of wing phenotype of tna1 (Gutierrez et al., 2003)
NOT Enhancer of
Statement Reference mor[+]/mor1 is a non-enhancer of phenotype of ct2s (Krupp et al., 2005) mor[+]/mor1 is a non-enhancer of phenotype of ct6 (Krupp et al., 2005) mor1 is a non-enhancer of dorsocentral bristle phenotype of ChiE (Heitzler et al., 2003) mor1 is a non-enhancer of eye phenotype of BEAF-32Scer\UAS.cYa, Scer\GAL4GMR.PS (Yamaguchi et al., 2001) mor1 is a non-enhancer of thorax phenotype of ChiE (Heitzler et al., 2003)
Suppressor of
Statement Reference mor[+]/mor1 is a suppressor | partially of eye phenotype of DrefScer\UAS.cSa, Scer\GAL4GMR.PS (Nakamura et al., 2008) mor[+]/mor1 is a suppressor | partially of triple row phenotype of ctK (Krupp et al., 2005) mor[+]/mor1 is a suppressor of antenna phenotype of AntpNs, Pc2 (Kennison and Tamkun, 1988) mor[+]/mor1 is a suppressor of eye phenotype of DrefScer\UAS.cSa, Scer\GAL4GMR.PS (Hirose et al., 2001) mor[+]/mor1 is a suppressor of eye phenotype of Scer\GAL4ey.PH, asf1Scer\UAS.cMa (Moshkin et al., 2002) mor1 is a suppressor of antenna phenotype of AntpNs (Brizuela and Kennison, 1997) mor1 is a suppressor of eye phenotype of CycEJP (Brumby et al., 2002) mor1 is a suppressor of eye phenotype of Scer\GAL4GMR.PF/Scer\GAL4GMR.PF, dmScer\UAS.cZa (Secombe et al., 2007) mor1 is a suppressor of mesothoracic leg phenotype of Pc4 (Brizuela and Kennison, 1997) mor1 is a suppressor of mesothoracic leg phenotype of Pcl10 (Brizuela and Kennison, 1997) mor1 is a suppressor of metathoracic leg phenotype of Pc4 (Brizuela and Kennison, 1997) mor1 is a suppressor of metathoracic leg phenotype of Pcl10 (Brizuela and Kennison, 1997) mor1 is a suppressor of sex comb phenotype of Pc4 (Brizuela and Kennison, 1997) mor1 is a suppressor of sex comb phenotype of Pcl10 (Brizuela and Kennison, 1997) mor1 is a suppressor of wing margin phenotype of Scer\GAL4vg.PM, sggS9A.Scer\UAS (Collins and Treisman, 2000) mor1 is a suppressor of wing phenotype of Scer\GAL4vg.PM, sggS9A.Scer\UAS (Collins and Treisman, 2000)
NOT Suppressor of
Statement Reference mor[+]/mor1 is a non-suppressor of phenotype of ct2s (Krupp et al., 2005) mor[+]/mor1 is a non-suppressor of phenotype of ct6 (Krupp et al., 2005) mor1 is a non-suppressor of dorsocentral bristle phenotype of ChiE (Heitzler et al., 2003) mor1 is a non-suppressor of eye phenotype of BEAF-32Scer\UAS.cYa, Scer\GAL4GMR.PS (Yamaguchi et al., 2001) mor1 is a non-suppressor of thorax phenotype of ChiE (Heitzler et al., 2003)
Other
Statement Reference akirinKG01343, mor[+]/mor1 has embryonic/larval somatic muscle phenotype (Nowak et al., 2012) brm2, mor1 has wing phenotype (Vazquez et al., 1999, Vazquez et al., 1999) corto[+]/corto420, mor1 has posterior crossvein phenotype (Lopez et al., 2001) corto420, mor1 has posterior crossvein phenotype (Lopez et al., 2001) HcfHR1, mor[+]/mor1 has leg phenotype (Rodriguez-Jato et al., 2011) lolalk02512, mor1 has eye phenotype (Mishra et al., 2003, Mishra et al., 2003) Su(var)3-3[+]/Su(var)3-3ΔN, mor1 has wing vein | ectopic phenotype (Curtis et al., 2011) γTub23CPl-2, mor1 has wing phenotype (Vázquez et al., 2008)
Additional Comments
Genetic Interactions
Statement Reference Stage 16 mor[1]/+ ; akirin[KG01343]/+ double heterozygous embryos show disruption of the somatic muscle pattern (40% of embryos have missing, misattached or duplicated muscles in at least 2 hemisegments). (Nowak et al., 2012) Su(var)3-3[ΔN] mor[1] double heterozygotes often have ectopic wing vein material posterior to vein L5 and distal to the posterior crossvein. (Curtis et al., 2011) Hcf[HR1] shows leg defects when in double heterozygous combination with mor[1] (10% penetrance). (Rodriguez-Jato et al., 2011) mor[1] acts as strong dominant enhancer of the penetrance of the e(y)3[4]/Y bent-leg phenotype in male flies. (Chalkley et al., 2008) γTub23C[Pl-2] results in a held-out wing phenotype in double heterozygous combination with mor[1] (10% penetrance). (Vázquez et al., 2008) The penetrance of the loss of humeral bristle phenotype seen in mor[1]/+ flies is increased by Bap60[1]/+ from 3% to 7%. (Moeller et al., 2005) The addition of lolalk02512/+ to heterozygous mor1 animals produces rough eyes. (Mishra et al., 2003) Strongly suppresses the CycEJP rough eye phenotype. (Brumby et al., 2002) mor1/+ suppresses the rough eye phenotype due to Scer\GAL4ey.PH; asf1Scer\UAS.cMa. (Moshkin et al., 2002) A mor[1]/+ background significantly suppresses the rough eye phenotype found in flies expressing Dref[Scer\UAS.cSa] under the control of Scer\GAL4[GMR.PS]. (Hirose et al., 2001) mor1 corto420 double heterozygotes show posterior crossvein defects. (Lopez et al., 2001) Mutant heterozygotes show a moderate enhancement of the eye phenotype see in P{UAS-lacZ.Abd-B.5F24} leading to lighter eyes. (Cavalli, 1999) The addition of mor1 enhances the eye size phenotype seen in osaScer\UAS.cCa/Scer\GAL4ey.PH flies, occasionally resulting in missing eyes. The reduction in growth seen in mor1 clones is partially rescued by the addition of osa308. (Collins et al., 1999) Enhances the phenotype of E2fGMR.PD DpGMR.PD BacA\p35GMR.PH flies. (Staehling-Hampton et al., 1999) brm2 shows some interaction in double heterozygous combination with mor1; slightly more than 20% of flies have held-out wings. (Vazquez et al., 1999) The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by mor1. (Maixner et al., 1998) Weak enhancer of eye pigment phenotype of wT81. (Netter et al., 1998) Suppresses the antenna to leg transformation phenotype of Pc2, AntpNs/+. Causes between 50% and 100% suppression of the Pc4/+ extra sex combs phenotype. (Kennison and Tamkun, 1988)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	morGS-A897 (Krupp et al., 2005) morksh-9 (Staehling-Hampton et al., 1999) morksh-10 (Staehling-Hampton et al., 1999)
Rescued by	mor2/mor1 is rescued by mor+t11.8 (Crosby et al., 1999) mor6/mor1 is rescued by mor+t11.8 (Crosby et al., 1999)
Comments
Stocks ( 2 )
Bloomington	3615 mor1/TM6B, Tb1
Kyoto	107129 mor1/TM6B, Tb1
Notes on Origin
Discoverer
External Crossreferences & Linkouts
Other Crossreferences
Linkouts
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	moira1 (Janody et al., 2004, Nowak et al., 2012) mor1 (Curtis et al., 2011, Hirose et al., 2001, Moeller et al., 2005, Vázquez et al., 2008, Rodriguez-Jato et al., 2011, Di Stefano et al., 2011, Chalkley et al., 2008, Nakamura et al., 2008) Mor1 (Secombe et al., 2007)
Name Synonym
Secondary FlyBase IDs
References ( 42 )
Generate a list of	All references relating to this allele ( 42 )
List References by type	Research paper  ( 40 ) Review  ( 1 ) Personal communication to FlyBase  ( 1 )
Recent research papers ( 4 )
	Nowak et al., 2012, PLoS Genet. 8(3): e1002547 Akirin Links Twist-Regulated Transcription with the Brahma Chromatin Remodeling Complex during Embryogenesis. [FBrf0217616] Curtis et al., 2011, Dev. Biol. 350(2): 534--547 Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development. [FBrf0212876] Di Stefano et al., 2011, Genes Dev. 25(1): 17--28 Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709] Rodriguez-Jato et al., 2011, PLoS ONE 6(12): e27479 Drosophila melanogaster dHCF Interacts with both PcG and TrxG Epigenetic Regulators. [FBrf0216958] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...