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General Information
Symbol
Dmel\mor1
Species
D. melanogaster
Name
FlyBase ID
FBal0012411
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
moira1
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

22.5% of heterozygous females have ectopic wing veins.

Heterozygotes have normal wings.

Flies heterozygous for mor1 show suppression of the Scer\GAL4GMR.PS, DrefScer\UAS.cSa severe rough eye phenotype; eyes are modestly rough and fused ommatidia are not apparent.

mor1/+ enhances the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5, P{hsp26-pt-T}39C-27 and P{hsp26-pt-T}39C-31. mor1/+ has no effect on the telomeric position effect (TPE) of P{wA}4-4.

mor1 clones show a severe reduction in growth phenotype.

Homozygous clones in the haltere can give rise to wing structures; many clones in the posterior haltere differentiate large bristles characteristic of anterior wing margin. Clones induced early in development cause the haltere to be absent, small, or have a homeotic transformation. Clones induced later (48-72 hours after egg laying) show more extreme transformations of haltere to anterior wing structures than early clones. Homozygous clones in the posterior wing cause distortions in wing shape; venation is disrupted and large socketed bristles appear along the posterior wing margin. Homozygous clones in the leg cause the femur and tibia to be short and twisted, and the tarsal segments to be enlarged. Leg clones also contain extra bristles. Clones in the anterior first leg are transformed to anterior second leg or have extra sex comb teeth. Clones in the second leg are twisted, have vesicles of extra tissue, or cause the absence of the entire leg. Tarsal segments are often fused, duplicated or absent. Clones in the third leg often have partial or complete duplications of distal structures, or the entire leg morphology is abnormal. Clones in the first and third legs often cause truncations of the leg. Eggs derived from homozygous germ-line clones fail to hatch and are very abnormal. These abnormalities include collapsed eggs, eggs with partial or no chorions, small or abnormally shaped eggs and fused and thick dorsal appendages.

Mutation changes the level of w expression in ph-plac+3 flies; eye colour is lighter.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

mor1 has visible | dominant phenotype, enhanceable by Bap60[+]/Bap601

Suppressed by
Statement
Reference

mor1 has visible | dominant phenotype, suppressible | partially by EloA[+]/EloAG4930

mor1 has visible | dominant phenotype, suppressible | partially by EloCSH1520/l(2)SH1520[+]

mor1 has visible | dominant phenotype, suppressible | partially by Elongin-C[+]/EloCSH1299

Enhancer of
Statement
Reference

mor[+]/mor1 is an enhancer of neuroanatomy defective phenotype of bratDG19310/brat11

mor[+]/mor1 is an enhancer of neuroanatomy defective phenotype of numbNP2301

mor[+]/mor1 is an enhancer of visible | dominant phenotype of Snr1E1

mor[+]/mor1 is an enhancer of visible phenotype of ct53d

mor1 is an enhancer of visible | dominant phenotype of tna1

mor1 is an enhancer of eye color defective phenotype of wT81

NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

mor[+]/mor1 is a suppressor | partially of visible phenotype of ctK

mor1 is a suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

mor1 is a suppressor of visible | dominant | adult stage phenotype of Pcl10

mor1 is a suppressor of visible | dominant phenotype of AntpNs

mor1 is a suppressor of visible | dominant | homeotic phenotype of Pc4

mor1 is a suppressor of visible | dominant | adult stage phenotype of Pc4

mor1 is a suppressor of visible | dominant | homeotic phenotype of Pcl10

mor[+]/mor1 is a suppressor of visible | homeotic phenotype of AntpNs, Pc2

NOT Suppressor of
Statement
Reference

mor1 is a non-suppressor of visible phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

mor1 has humeral bristle phenotype, enhanceable by Bap60[+]/Bap601

NOT Enhanced by
Statement
Reference

mor1 has phenotype, non-enhanceable by Alhunspecified

Suppressed by
Statement
Reference

mor1 has wing vein | ectopic phenotype, suppressible | partially by EloA[+]/EloAG4930

mor1 has wing vein | ectopic phenotype, suppressible | partially by EloCSH1520/l(2)SH1520[+]

mor1 has wing vein | ectopic phenotype, suppressible | partially by Elongin-C[+]/EloCSH1299

mor1 has phenotype, suppressible by osa308

NOT suppressed by
Statement
Reference

mor1 has phenotype, non-suppressible by Alhunspecified

Enhancer of
Statement
Reference

mor[+]/mor1 is an enhancer of type II neuroblast | supernumerary phenotype of numbNP2301

mor[+]/mor1 is an enhancer of wing vein | ectopic phenotype of Snr1E1

mor[+]/mor1 is an enhancer of leg phenotype of e(y)34

mor[+]/mor1 is an enhancer of wing phenotype of ct53d

mor[+]/mor1 is an enhancer of wing vein | ectopic phenotype of net1

mor1 is an enhancer of wing phenotype of tna1

mor1 is an enhancer of eye phenotype of Scer\GAL4ey.PH, osaUAS.cCa

NOT Enhancer of
Statement
Reference

mor[+]/mor1 is a non-enhancer of phenotype of ct2s

mor[+]/mor1 is a non-enhancer of phenotype of ct6

mor1 is a non-enhancer of dorsocentral bristle phenotype of ChiE

mor1 is a non-enhancer of thorax phenotype of ChiE

mor1 is a non-enhancer of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS

Suppressor of
Statement
Reference

mor[+]/mor1 is a suppressor | partially of eye phenotype of DrefUAS.cSa, Scer\GAL4GMR.PS

mor[+]/mor1 is a suppressor | partially of triple row phenotype of ctK

mor1 is a suppressor of eye phenotype of CycEJP

mor[+]/mor1 is a suppressor of eye phenotype of Scer\GAL4ey.PH, asf1UAS.cMa

mor[+]/mor1 is a suppressor of eye phenotype of DrefUAS.cSa, Scer\GAL4GMR.PS

mor1 is a suppressor of mesothoracic leg phenotype of Pcl10

mor1 is a suppressor of metathoracic leg phenotype of Pcl10

mor1 is a suppressor of sex comb phenotype of Pcl10

mor1 is a suppressor of antenna phenotype of AntpNs

mor1 is a suppressor of mesothoracic leg phenotype of Pc4

mor1 is a suppressor of metathoracic leg phenotype of Pc4

mor1 is a suppressor of sex comb phenotype of Pc4

mor[+]/mor1 is a suppressor of antenna phenotype of AntpNs, Pc2

NOT Suppressor of
Statement
Reference

mor[+]/mor1 is a non-suppressor of phenotype of ct2s

mor[+]/mor1 is a non-suppressor of phenotype of ct6

mor1 is a non-suppressor of dorsocentral bristle phenotype of ChiE

mor1 is a non-suppressor of thorax phenotype of ChiE

mor1 is a non-suppressor of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS

Other
Additional Comments
Genetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is exacerbated by combination with a single copy of mor1.

Flies heterozygous for both RelE20 and mor1 show a significant decrease in survival following Erwinia carotovora Ecc15 infection.

One copy of mor1 enhances the supernumerary neuroblast phenotype seen in bratDG19310/brat11 mutants.

One copy of mor1 enhances the supernumerary neuroblast phenotype seen in numbNP2301 mutant larval brains.

The penetrance of the ectopic wing vein phenotype seen in mor1/+ females (22.5% penetrance) is reduced if they are also heterozygous for one of EloAG4930 (5.5% penetrance), EloCSH1520 (1.5%) or EloCSH1299 (6.4%).

Stage 16 mor1/+ ; akirinKG01343/+ double heterozygous embryos show disruption of the somatic muscle pattern (40% of embryos have missing, misattached or duplicated muscles in at least 2 hemisegments).

Su(var)3-3ΔN mor1 double heterozygotes often have ectopic wing vein material posterior to vein L5 and distal to the posterior crossvein.

HcfHR1 shows leg defects when in double heterozygous combination with mor1 (10% penetrance).

mor1 acts as strong dominant enhancer of the penetrance of the e(y)34/Y bent-leg phenotype in male flies.

γTub23CPl-2 results in a held-out wing phenotype in double heterozygous combination with mor1 (10% penetrance).

The penetrance of the loss of humeral bristle phenotype seen in mor1/+ flies is increased by Bap601/+ from 3% to 7%.

The addition of lolalk02512/+ to heterozygous mor1 animals produces rough eyes.

Strongly suppresses the CycEJP rough eye phenotype.

mor1/+ suppresses the rough eye phenotype due to Scer\GAL4ey.PH; asf1Scer\UAS.cMa.

A mor1/+ background significantly suppresses the rough eye phenotype found in flies expressing DrefScer\UAS.cSa under the control of Scer\GAL4GMR.PS.

mor1 corto420 double heterozygotes show posterior crossvein defects.

Mutant heterozygotes show a moderate enhancement of the eye phenotype see in P{UAS-lacZ.Abd-B.5F24} leading to lighter eyes.

The addition of mor1 enhances the eye size phenotype seen in osaScer\UAS.cCa/Scer\GAL4ey.PH flies, occasionally resulting in missing eyes. The reduction in growth seen in mor1 clones is partially rescued by the addition of osa308.

brm2 shows some interaction in double heterozygous combination with mor1; slightly more than 20% of flies have held-out wings.

The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by mor1.

Weak enhancer of eye pigment phenotype of wT81.

Suppresses the antenna to leg transformation phenotype of Pc2, AntpNs/+. Causes between 50% and 100% suppression of the Pc4/+ extra sex combs phenotype.

Xenogenetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is exacerbated by combination with a single copy of mor1.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (47)