Some homozygous larvae have melanotic tumours.
11.6% of mrn1/mrn3 larvae have necrosis or melanotic tumours.
mrnEP3605/mrn1 larvae show general necrosis.
Heterozygous larvae are more sensitive to UVB irradiation compared to controls.
Homozygous larvae and pupae are smaller than controls.
Aberrant egg chambers are seen in mrnEP3605/mrn1 females and pycnotic nuclei are seen in nurse cells.
mrnEP3605/mrn1 males have defective testes, and spermatogenesis is either absent or not completed in most cases.
Mitotic spreads of mrnEP3605/mrn1 larval neuroblasts show a high rate of chromosome aberrations, including fragmentation of chromosomes and partial chromosome condensation.
Homozygous mutant clones induced in the eye using the eyFLP method are hardly detected in the adult eye. Homozygous mutant clones induced in the eye using the eyFLP method in a Minute/+ background are recovered in the eye disc, although these clones are much smaller than control clones.
Massive apoptosis is induced in homozygous clones in the eye disc 4 hours after UV irradiation of 500 J/m (apoptosis is not induced in wild-type clones under these conditions).
BrdU incorporation is absent posterior to the morphogenetic furrow in homozygous clones in the eye disc.