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General Information
Symbol
Dmel\mrn1
Species
D. melanogaster
Name
FlyBase ID
FBal0012434
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G15579434A

Amino acid change:

E340K | mrn-PA

Reported amino acid change:

E340K

Comment:

One of two missense mutations associated with this allele; site of nucleotide substitution in mutant inferred

by FlyBase based on reported amino acid change.

point mutation
Nucleotide change:

G15579500C

Amino acid change:

A318P | mrn-PA

Reported amino acid change:

A318P

Comment:

One of two missense mutations associated with this allele; site of nucleotide substitution in mutant inferred

by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: E340K.

Nucleotide substitution: G1018A.

Amino acid replacement: A318P.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Some homozygous larvae have melanotic tumours.

11.6% of mrn1/mrn3 larvae have necrosis or melanotic tumours.

mrnEP3605/mrn1 larvae show general necrosis.

Heterozygous larvae are more sensitive to UVB irradiation compared to controls.

Homozygous larvae and pupae are smaller than controls.

Aberrant egg chambers are seen in mrnEP3605/mrn1 females and pycnotic nuclei are seen in nurse cells.

mrnEP3605/mrn1 males have defective testes, and spermatogenesis is either absent or not completed in most cases.

Mitotic spreads of mrnEP3605/mrn1 larval neuroblasts show a high rate of chromosome aberrations, including fragmentation of chromosomes and partial chromosome condensation.

Homozygous mutant clones induced in the eye using the eyFLP method are hardly detected in the adult eye. Homozygous mutant clones induced in the eye using the eyFLP method in a Minute/+ background are recovered in the eye disc, although these clones are much smaller than control clones.

Massive apoptosis is induced in homozygous clones in the eye disc 4 hours after UV irradiation of 500 J/m[2] (apoptosis is not induced in wild-type clones under these conditions).

BrdU incorporation is absent posterior to the morphogenetic furrow in homozygous clones in the eye disc.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

mrn1 has lethal | recessive phenotype, non-suppressible by Tfb5Hsp83.PAF

mrnEP3605/mrn1 has sterile phenotype, non-suppressible by Hsap\GTF2H4Hsp83.PF

Phenotype Manifest In
Enhancer of
Statement
Reference

mrn1 is an enhancer of phenotype of βTub85Dunspecified

Additional Comments
Genetic Interactions
Statement
Reference

Fails to complement class I alleles at the βTub85D locus.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially complements
Partially rescued by

mrn1 is partially rescued by mrnHsp83.PF

mrn1 is partially rescued by mrnHsp83.PF

Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a mutation that fails to complement class I alleles at the βTub85D locus (either βTub85D3 or βTub85DDrv1) but does not map to the βTub85D locus.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)