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General Information
Symbol
Dmel\eIF4G2nc32
Species
D. melanogaster
Name
FlyBase ID
FBal0012548
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T23811996A

Amino acid change:

M1506K | eIF4G2-PA; M1506K | eIF4G2-PC

Reported amino acid change:

M1467K

Comment:

The reported amino acid location is based on an isoform with an intron that removes 39 aa from the first exon of RA.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: M1467K.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous males do not undergo meiosis and show no recognisable meiotic or postmeiotic stages of spermatid differentiation. The testes contain cells in the gonial stage, cysts of primary spermatocytes and cysts of aberrant cells in a terminal stage that may represent degenerating primary spermatocytes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

eIF4G2nc32 is an enhancer of phenotype of βTub85Dunspecified

Additional Comments
Genetic Interactions
Statement
Reference

Fails to complement class I alleles at the βTub85D locus. Meiosis and spermatid differentiation occur in the sterile transheterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a mutation that fails to complement class I alleles at the βTub85D locus (either βTub85D3 or βTub85DDrv1) but does not map to the βTub85D locus.

Comments
Comments

Adult homozygous males show no βTub85D synthesis.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
ms(3)nc321
Name Synonyms
Secondary FlyBase IDs
    References (2)