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General Information
Symbol
Dmel\msl-21
Species
D. melanogaster
Name
FlyBase ID
FBal0012561
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
msl21, msl-2
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C3465488T

Reported nucleotide change:

C628T

Amino acid change:

P51L | msl-2-PA; P51L | msl-2-PB

Reported amino acid change:

P51L

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: P?L.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

male-lethal

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

msl-2[+]/msl-21 is an enhancer of lethal | male phenotype of Trl62/Trl13C

msl-2[+]/msl-21 is an enhancer of lethal | male phenotype of Trl2.3/Trl13C

msl-11, msl-1[+], msl-2[+], msl-21, mle1, mle[+] is an enhancer of lethal | male phenotype of Trl62/Trl13C

NOT Enhancer of
Statement
Reference

msl-2[+]/msl-21 is a non-enhancer of partially lethal | female phenotype of Trl2.3/Trl13C

msl-11, msl-1[+], msl-2[+], msl-21, mle1, mle[+] is a non-enhancer of partially lethal | female phenotype of Trl62/Trl13C

Suppressor of
Statement
Reference

msl-2[+]/msl-21 is a suppressor | partially of lethal | male phenotype of ocmL1658N/ocmG1646E

NOT Suppressor of
Statement
Reference

msl-2[+]/msl-21 is a non-suppressor of partially lethal | female phenotype of Trl2.3/Trl13C

msl-11, msl-1[+], msl-2[+], mle1, msl-21, mle[+] is a non-suppressor of partially lethal | female phenotype of Trl2.3/Trl13C

Other
Phenotype Manifest In
NOT Suppressor of
Statement
Reference

msl-2138/msl-21 is a non-suppressor of ovary phenotype of ovoD1rv22

msl-2138/msl-21 is a non-suppressor of ovary phenotype of ovoD1rv23

Other
Additional Comments
Genetic Interactions
Statement
Reference

The viability of SxlfP7B0/+ females is significantly reduced if they also carry one maternally-derived copy of msl-21.

One maternally-derived copy of msl-21 significantly reduces the viability of scsisB-1 sisA1/+ females so that they show almost complete lethality. One paternally-derived copy of msl-21 significantly reduces the viability of scsisB-1 sisA1/+ females, although this zygotic effect is generally weaker than the maternal one.

Ovaries of ovoD1rv23/ovoD1rv22 females contain germline chambers in less than 20% of cases. The phenotype is not affected if the females are also carrying msl-2138/msl-21.

Some females homozygous for msl-21 and heterozygous for Sxlf1 have sex combs on the basitarsi of their forelegs. This phenotype occurs with a higher frequency in females with homozygous msl-21 mothers.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Not rescued by
Comments

msl-21 homozygous males carrying msl-2hs.T:Avic\GFP-Venus show a survival rate of 60% at 25[o]C.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Belote.

Comments
Comments

Clonal analysis indicates that msl-2 acts in a cell autonomous manner, and is required in imaginal discs and histoblasts at some time after blastoderm formation in males. The requirement in the imaginal discs is late in development, during mid to late third instar. Clonal analysis also shows that the msl-2 mutation does not affect sexual differentiation.

H4Ac16, acetylated form of His4, is not localised to the X chromosome in male salivary gland nuclei.

γ ray induced revertants of msl-21 are cytologically normal.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (18)