Allele Dmel\mu2¹

General Information
Symbol	Dmel\mu2¹	Species	D. melanogaster
Name		FlyBase ID	FBal0012569
Feature type	allele	Associated gene	Dmel\mu2
Also Known As	mu2^a

Allele class
Mutagen	spontaneous
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Stocks FBst0043636
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	spontaneous
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference mu2¹ and mu2¹/Df(3L)Aprt-1 mutants have a similar frequency of single-strand annealing repair (SSA) compared to controls in a P{wIw.FRT} hemizygous assay to study DNA double-stranded break repair when assayed at 38^oC, but show an increased SSA frequency compared to controls when assayed at 32^oC. (Wei and Rong, 2007) Homozygous larvae do not show higher sensitivity to killing by methyl methanesulfonate or radiation than wild type. mu2¹ shows a 6-fold increase in the frequency of total y^- and f^36a spots and a 17-fold increase in the frequency of twin spots in the abdomen of unirradiated y^- + / + f^36a females compared to controls. γ irradiation has no discernible effect on the frequency of spots in mu2¹ females in contrast to wild type. (Kasravi et al., 1999) Lesions induced by γ rays in sperm chromosomes are repaired after fertilisation, while lesions induced in oocyte chromosomes are shunted instead to a mechanism that stabilises broken chromosome ends. (Mason et al., 1997) Irradiation of females homozygous for mu2¹ with low doses of X rays produces substantial numbers of terminal deficiencies for all chromosome arms <up>see for example Df(1)yT</up>; irradiation of heterozygous females produces frequencies of deficiencies intermediate between those obtained from homozygous mu2¹ and wild-type females. Extents of deficiencies limited only by the ability to recover them in viable offspring. Incidence of terminal losses linear with dose; such deficiencies visible cytologically and can be shown by in situ hybridization to lack sequences characteristically present at the termini of chromosome arms. Irradiation of mu2¹ females does not increase the incidence of either interstitial deficiencies or sex-linked lethal mutations. Irradiation of mu2¹ males does not increase the frequency of deficiencies.
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	mu2¹ is rescued by mu2^+t8.5 (Kasravi et al., 1999) mu2¹ is rescued by mu2^+t10.3 (Kasravi et al., 1999)
Not rescued by	mu2¹ is not rescued by mu2^tA6c (Kasravi et al., 1999)
Comments
Stocks ( 4 )
Bloomington	43636 mwh¹ rho^ve-1 mu2¹ 1220 mu2¹ st¹/TM6C, ca¹
Kyoto	106251 mu2¹ st¹/TM6C, ca¹ 101895 Dp(1;Y)B^S ; mu2¹ st¹
Notes on Origin
Discoverer	M.M. Green.

Comments
	Df(3R)sbd105 fails to complement mu2¹. (Wang et al., 1994)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	mu2¹ (Wei and Rong, 2007) mu2^a (Kasravi et al., 1999, Mason et al., 1997, Wang et al., 1994)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Wei and Rong, 2007, Genetics 177(1): 63--77 A genetic screen for DNA double-strand break repair mutations in Drosophila. [FBrf0201349] Kasravi et al., 1999, Genetics 152(3): 1025--1035 Molecular cloning and tissue-specific expression of the mutator2 gene (mu2) in Drosophila melanogaster. [FBrf0110051] Mason et al., 1997, Genetics 146(4): 1381--1397 Germ-line effects of a mutator, mu2, in Drosophila melanogaster. [FBrf0095657] Wang et al., 1994, Mol. Gen. Genet. 245(5): 598--607 Mapping a mutator, mu2, which increases the frequency of terminal deletions in Drosophila melanogaster. [FBrf0076966]

Allele Dmel\mu21

Allele Dmel\mu2¹