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General Information
Symbol
Dmel\mus304D2
Species
D. melanogaster
Name
FlyBase ID
FBal0012648
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
mus3042
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G18112342A

Amino acid change:

W759term | mus304-PA

Reported amino acid change:

W759term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified)

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: W759term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

mus304D2 mutant cells exhibit DNA breaks and telomere fusions in metaphase and anaphase at almost the same level as wild-type cells.

mus304D2 animals show a strong defect in a DNA damage checkpoint assay in the eye disc. mus304D2/Df(3L)W4 animals have macrochaetae defects (probably due genomic instability resulting in the loss of genetic material at haploinsufficient Minute loci). mus304D1/mus304D2 flies have wild-type eyes. Loss of heterozygosity is elevated compared to wild-type in mus304D2/Df(3L)W4 animals.

Hypersensitive to methyl methanesulfonate. Sensitive to 0.008% HN2.

female-sterile

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

nbs1 mus304D2 double mutant cells exhibit more DNA breaks and telomere fusions in metaphase and anaphase than in wild-type cells.

tefu1 mus304D2 double mutant cells exhibit more DNA breaks and telomere fusions in metaphase and anaphase than in wild-type cells.

The frequency of macrochaetae defects in mus304D2/Df(3L)W4 animals is increased by one copy of E(mus304)1. If mus304D1/mus304D2 flies are also heterozygous for E(mus304)1 they have rough eyes and abnormal or missing bristles.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Boyd.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)