Allele Dmel\mwh¹

General Information
Symbol	Dmel\mwh¹	Species	D. melanogaster
Name		FlyBase ID	FBal0012675
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\mwh

Allele class
Mutagen	spontaneous
Nature of the Allele
Allele class
Mutagen	spontaneous (University of Milan, 1951)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Assay mode
Carried on aberration	TM1-mr (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28) Dp(3;3)Cam34 (Roote, 2000.3.14, Roote, 2004.6.24)
Cytology
Phenotypic Data
Phenotypic Class
	viable (University of Milan, 1951) visible (Dickinson and Thatcher, 1997) visible \| recessive (University of Milan, 1951) tissue polarity \| cell autonomous \| somatic clone (Lee and Adler, 2002)
Phenotype Manifest In
	wing cell (Wong and Adler, 1993) wing hair (Wong and Adler, 1993) denticle belt (Dickinson and Thatcher, 1997) microchaeta (Dickinson and Thatcher, 1997) microchaeta & wing (University of Milan, 1951) wing hair \| cell autonomous \| somatic clone (Lee and Adler, 2002)
Detailed Description
	Statement Reference Affects the trichomes (hairs) of all body regions in the same general way: An increase in the number of elements is correlated with a reduction in length and a disturbance of orientation. Aristae and bracts are included in this pattern; bristles and other sensilla are not. Wing cells contain groups of 2-7 hairs instead of one hair per cell as in wild type; causes supernumerary trichomes over entire integument, but tufts of trichomes only in wing blade (Ouweneel, 1970); may be supernumerary hairs and sensilla on halteres (Ouweneel and van der Meer, 1973). Also causes disruption of polarity in legs, wings and halteres; may disrupt orientation of hairs on leg without affecting their numbers (Bryant and Schneiderman, 1969); trichomes on wings tend to diverge from vein L3 rather than parallel it as in wild type (Gubb and Garcia-Bellido, 1982). mwh/+ develop mwh phenotype following heat shock at or just prior to the time of cell-hair-extrusion (Mitchell and Petersen, 1984). Transplants of mutant wing discs to wild-type hosts develop autonomously (Ursprung and Hadorn, 1962). Widely used as a cell marker in the analysis of cuticular clones. The frequency of mwh spots after somatic recombination in mwh/+ flies increases with increase in the temperature at which the larvae and pupae are raised (Graf, 1986). RK1. Wing cells of homozygous flies form more than one hair, with an average of almost four hairs per cell. Homozygous flies have disruptions in the pattern of wing hair polarity. The prehair initiation site is along the cell periphery, but not restricted to the distal vertex in pupal wing cells. Double mutants of mwh¹ with fz¹, dsh¹, pk¹, in¹ or fy² resemble mwh¹ single mutants. (Wong and Adler, 1993) RK1 Hairs on the wings are grouped in numbers of 2-5 in the place of 1. (University of Milan, 1951) Hairs and denticles are smaller, more numerous and less orderly than those in wild type. (Dickinson and Thatcher, 1997) Mutants show no significant disruption of ovarian morphology. (Cohen et al., 2002) Mutant clones in the wing show disruption of polarity, as indicated by wing hairs. (Lee and Adler, 2002)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference mwh¹ has tissue polarity \| somatic clone phenotype, non-enhanceable by grh^IM (Lee and Adler, 2004)
NOT suppressed by
Statement Reference mwh¹ has tissue polarity \| somatic clone phenotype, non-suppressible by grh^IM (Lee and Adler, 2004)
NOT Enhancer of
Statement Reference mwh¹ is a non-enhancer of tissue polarity \| somatic clone phenotype of grh^IM (Lee and Adler, 2004)
Suppressor of
Statement Reference mwh¹ is a suppressor of tissue polarity \| somatic clone \| cell non-autonomous phenotype of fz²³ (Lee and Adler, 2002)
NOT Suppressor of
Statement Reference mwh¹ is a non-suppressor of tissue polarity \| somatic clone \| cell autonomous phenotype of fz²³ (Lee and Adler, 2002) mwh¹ is a non-suppressor of tissue polarity \| somatic clone \| cell non-autonomous phenotype of fz²³ (Lee and Adler, 2002) mwh¹ is a non-suppressor of tissue polarity \| somatic clone phenotype of grh^IM (Lee and Adler, 2004)
Phenotype Manifest In
Enhanced by
Statement Reference mwh¹ has wing hair \| somatic clone phenotype, enhanceable by ultA¹ (Adler et al., 2000)
NOT Enhanced by
Statement Reference mwh¹ has wing hair \| somatic clone phenotype, non-enhanceable by grh^IM (Lee and Adler, 2004) mwh¹ has wing hair \| supernumerary \| somatic clone phenotype, non-enhanceable by grh^IM (Lee and Adler, 2004)
NOT suppressed by
Statement Reference mwh¹ has wing hair \| somatic clone phenotype, non-suppressible by grh^IM (Lee and Adler, 2004) mwh¹ has wing hair \| supernumerary \| somatic clone phenotype, non-suppressible by grh^IM (Lee and Adler, 2004)
Enhancer of
Statement Reference mwh[+]/mwh¹ is an enhancer of wing hair & 1st posterior cell phenotype of fy² (Lee and Adler, 2002) mwh[+]/mwh¹ is an enhancer of wing hair & 1st posterior cell phenotype of in¹ (Lee and Adler, 2002) mwh¹ is an enhancer of wing hair \| somatic clone phenotype of ultA¹ (Adler et al., 2000) mwh[+]/mwh¹ is an enhancer of wing hair & 1st posterior cell phenotype of in^II53 (Lee and Adler, 2002)
NOT Enhancer of
Statement Reference mwh¹ is a non-enhancer of wing hair \| somatic clone phenotype of grh^IM (Lee and Adler, 2004) mwh¹ is a non-enhancer of wing hair \| supernumerary \| somatic clone phenotype of grh^IM (Lee and Adler, 2004)
Suppressor of
Statement Reference mwh¹ is a suppressor of wing hair \| somatic clone \| cell non-autonomous phenotype of fz²³ (Lee and Adler, 2002)
NOT Suppressor of
Statement Reference mwh¹ is a non-suppressor of wing hair \| somatic clone \| cell autonomous phenotype of fz²³ (Lee and Adler, 2002) mwh¹ is a non-suppressor of wing hair \| somatic clone \| cell non-autonomous phenotype of fz²³ (Lee and Adler, 2002) mwh¹ is a non-suppressor of wing hair \| somatic clone phenotype of grh^IM (Lee and Adler, 2004) mwh¹ is a non-suppressor of wing hair \| supernumerary \| somatic clone phenotype of grh^IM (Lee and Adler, 2004)
Additional Comments
Genetic Interactions
Statement Reference In somatic clones of cells that are homozygous for both mwh¹ and ultA¹, an increase is seen in the average number of wing hairs per cell. (Adler et al., 2000) When grh^IM mutant clones are made in an mwh¹ mutant wing the grh^IM phenotype is still seen. A slight additive effect is seen on the phenotype. (Lee and Adler, 2004)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 313 )
Bloomington	549 mwh¹ 677 y¹; mwh¹ 5747 Dp(3;3)Cam37, mwh¹/TM1 2558 mwh¹ ry⁵⁰⁶ e¹ 479 mwh¹ rho^ve-1 h¹ 3678 Df(3R)sbd45, mwh¹ e¹/TM6
Kyoto	101704 mwh¹ 105974 mwh¹ 101892 Basc ; mwh¹ 108403 Dp(3;3)Cam37, mwh¹/TM1 107402 mwh¹ ry⁵⁰⁶ e¹ 105933 mwh¹ rho^ve-1 h¹
	More stocks available...
Notes on Origin
Discoverer

Comments
	Isolated from Moltrasio. (University of Milan, 1951)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	mwh (University of Milan, 1951) mwh¹ (Jafar-Nejad et al., 2006) unnamed (Roote, 2004.6.24)
Name Synonym	multiple wing hairs (University of Milan, 1951)
Secondary FlyBase IDs

References ( 15 )
Research paper	Jafar-Nejad et al., 2006, Development 133(9): 1683--1692 Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. [FBrf0190299] Lee and Adler, 2004, Mech. Dev. 121(1): 37--49 The grainy head transcription factor is essential for the function of the frizzled pathway in the Drosophila wing. [FBrf0167844] Cohen et al., 2002, Dev. Cell 2(4): 437--448 DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. [FBrf0146974] Lee and Adler, 2002, Genetics 160(4): 1535--1547 The function of the frizzled pathway in the Drosophila wing is dependent on inturned and fuzzy. [FBrf0147064] Strutt, 2001, Molec. Cell 7(2): 367--375 Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing. [FBrf0134764] Adler et al., 2000, genesis 28(2): 82--91 Cell size and the morphogenesis of wing hairs in Drosophila. [FBrf0131239] Usui et al., 1999, Cell 98(5): 585--595 Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. [FBrf0111508] Dickinson and Thatcher, 1997, Cell Motility Cytoskel. 38(1): 9--21 Morphogenesis of denticles and hairs in Drosophila embryos: involvement of actin-associated proteins that also affect adult structures. [FBrf0098231] Wong and Adler, 1993, J. Cell Biol. 123(1): 209--221 Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells. [FBrf0064754] University of Milan, 1951, D. I. S. 25: 70 [New mutants report.] [FBrf0097183]
Personal communication to FlyBase	Roote, 2004.6.24, Cam Dps. Cam Dps. [FBrf0178882] Bloomington Drosophila Stock Center, 2001.8.28, Balancer Variants. Balancer Variants. [FBrf0138610] Roote, 2000.3.14, Dp(3;3)Cam's. Dp(3;3)Cam's. [FBrf0126882]
Abstract	Mitchell and Petersen, 1984, Genetics 107(3/2): s74 Recessive phenotypes of Drosophila uncovered by heat shock. [FBrf0041041]
FlyBase analysis	FlyBase Curators, 2006-, Balancer summary information. Balancer summary information. [FBrf0189689]

Allele Dmel\mwh1

Allele Dmel\mwh¹