Open Close
General Information
Symbol
Dmel\NAx-tsl
Species
D. melanogaster
Name
FlyBase ID
FBal0012861
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes and hemizygotes do not survive at 29oC. The number and length of wing vein breaks remains roughly equal from 18oC to 25oC in homozygous flies.

Lethal in combination with Df(1)N-8 at 29oC. Homozygous lethal at 29oC (44% survive at 18oC). Wings show an abruptex phenotype in 100% of heterozygotes at both 18oC and 29oC. Homozygotes express the abruptex phenotype more extremely than heterozygotes at 18oC. 10% of NAx-59d/NAx-tsl flies survive and have an abruptex phenotype at 29oC. 50% of Nl1N-2/NAx-tsl flies survive at 29oC. Phenotypes seen include small eyes and head, an abruptex phenotype and fused legs. 29% of Nl1N-3/NAx-tsl flies survive at 29oC. Phenotypes seen include small eyes and head, an abruptex phenotype and stubby legs. 27% of Nl1N-69e/NAx-tsl flies survive at 29oC. Phenotypes seen include small eyes which are sometimes rough and an abruptex phenotype. 2% of NAx-tsl/Nl1N-ts1 flies survive at 29oC. Phenotypes seen include stubby legs and an abruptex phenotype. 40% of Nl1N-ts2/NAx-tsl flies survive at 29oC and have an abruptex phenotype. Lethal in combination with N55e11, N264-39, N264-40, N60g11, N69d5 or N69e2 at 29oC. Nl1N-ts1 and NAx-tsl show negative complementation at 18oC; Nl1N-ts1/NAx-tsl flies do not survive as well as either homozygote.

Ax phenotype 100% penetrant in heterozygotes at 18oC and 29oC; homozygous lethal at 29oC and semi-lethal at 18oC. Surviving homozygotes have a stronger Ax expression than in heterozygotes. Lethal with N mutants at 29oC and semi-lethal with NAx-59d. Ax in phenotype and complementary with recessive visibles at Notch at 18oC and noncomplementary at 29oC. On the genetic map of the Notch locus to the right of spl.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

NAx-tsl has lethal | recessive | heat sensitive phenotype, suppressible | partially by E(spl)m8-HLH1

Other
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

NAx-tsl has wing vein phenotype, suppressible by E(spl)m8-HLH1

Suppressor of
Statement
Reference

NAx-tsl/N[+] is a suppressor of wing vein | ectopic phenotype of Snr1E1

Additional Comments
Genetic Interactions
Statement
Reference

NAx-tsl ; E(spl)1 double mutants show semi-lethality at 29oC. The number and length of wing vein breaks are rescued to wild type in NAx-tsl; E(spl)1 double mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Shellenbarger.

Induced in: Oregon-R stock.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Axtsl
NAx-tsl
l(1)Axtsl
Name Synonyms
Secondary FlyBase IDs
    References (3)