Allele Dmel\N^fa-1

General Information
Symbol	Dmel\N^fa-1	Species	D. melanogaster
Name		FlyBase ID	FBal0012863
Feature type	allele	Created / Updated	2006-05-15/2006-05-15
Associated gene	Dmel\N

Allele class
Mutagen	spontaneous
Nature of the Allele
Allele class
Mutagen	spontaneous (Grimwade et al., 1985)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference opus at -11.9 to -11.2 Insert stated as cause: middle repetitive DNA (inserted between coordinates -8.4 and -10.9, zero coordinate is defined as the centre of the 2.2kb EcoRI fragment that encompasses the N^76b8 inversion breakpoint). (Grimwade et al., 1985) Insertion of a copia-like element at coordinate -11kb (coordinates according to FBrf0045027 and FBrf0039003). (Kelley et al., 1987) Insertion transposable element opus into the second intron. (Gorman and Girton, 1992)
Assay mode
Caused by insertion	opus{}N^fa-1 (Gorman and Girton, 1992)
Cytology
Phenotypic Data
Phenotypic Class
	visible (Rabinow and Birchler, 1990) visible \| recessive (Glass, 1933, Welshons, 1974, Lewis, 1945, Gorman and Girton, 1992) visible \| recessive \| conditional - heat sensitive (Shellenbarger and Mohler, 1975)
Phenotype Manifest In
	eye \| conditional - heat sensitive (Shellenbarger and Mohler, 1975) ommatidium \| conditional - heat sensitive (Shellenbarger and Mohler, 1975) wing (Shellenbarger and Mohler, 1975, Glass, 1933) eye (Glass, 1933, Rabinow and Birchler, 1990, Lewis, 1945) ommatidium (Glass, 1933) wing margin bristle (Glass, 1933) retina \| somatic clone (Markopoulou and Artavanis-Tsakonas, 1991) optic lobe \| somatic clone (Markopoulou and Artavanis-Tsakonas, 1991) ommatidium \| somatic clone (Markopoulou and Artavanis-Tsakonas, 1991) lamina neuropil \| somatic clone (Markopoulou and Artavanis-Tsakonas, 1991) lamina cortex \| somatic clone (Markopoulou and Artavanis-Tsakonas, 1991)
Detailed Description
	Statement Reference Eyes of all males moderately rough owing to irregularity in size, shape and arrangement of facets. Not dosage compensated; eyes of females less rough than those of males with about 10% overlap of wild type. Eye roughness of the females varies from nearly normal at 18^oC to marked at 29^oC; pupal stage temperature-sensitive (Shellenbarger and Mohler, 1975). Eye abnormality caused by overgrowth of secondary pigment cells, which compresses cones and causes overlying corneal facets to bulge (Waddington and Pilkington, 1942). Wings have apical nicks in 0.25% of males and 0-5% of females. N/N^fa-1 has rough eyes of N^fa-1 as well as a Notch phenotype weak allele temperature sensitive nicked wings not dosage compensated N^fa-1/Df(1)N-8 flies show disarrangement of the ommatidia, while it is comparatively rare that the posterior wing margin shows any notching. N^nd-0/N^fa-1 is phenotypically normal, except in very rare cases (0.26%) where slight notches in the wing are seen. (Glass, 1933) Homozygotes have rough eyes. (Lewis, 1945) Expression of the mutant phenotype is mild and variable. (Welshons, 1974) At 29^oC, the eyes are rough and splotchy in homozygous females and there is a low penetrance of apical nicks in the wing. At 25^oC eye roughness is weaker, and at 18^oC the eyes are almost normal. (Shellenbarger and Mohler, 1975) Homozygotes exhibit rough eyes. (Rabinow and Birchler, 1990) Retina defects are associated with optic lobe defects in 81.8% of homozygous N^fa-1 retina clones generated by somatic recombination. The arrangement of ommatidia is abnormal in homozygous clones in the retina. A disruption of the fenestrated zone and laminar cortex, and a few small vacuoles in the lamina neuropil can be seen in the underlying optic lobe if it is defective. (Markopoulou and Artavanis-Tsakonas, 1991) Slightly rough eyes. (Gorman and Girton, 1992) N⁴⁷ⁱ/N^fa-1 flies show no phenotypic effect. N^51d in combination with N^fa-1 shows a characteristic phenotype. (Meyer, 1952)
Interactions
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement Reference N^fa-1 has phenotype, non-enhanceable by E(S)¹ (Lewis, 1945)
NOT suppressed by
Statement Reference N^fa-1 has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968)
Additional Comments
Genetic Interactions
Statement Reference E(S)¹ has little or no effect on the rough eye phenotype in ec^unspecified E(S)¹ double heterozygotes. (Lewis, 1945) Synergistic interactions with dx alleles. (Gorman and Girton, 1992)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	N^Ax-tsl (Shellenbarger and Mohler, 1975) N^fa-g (Shellenbarger and Mohler, 1975) N^l1N-ts1 (Shellenbarger and Mohler, 1975) N^l1N-ts2 (Shellenbarger and Mohler, 1975) N^nd-1 (Shellenbarger and Mohler, 1975) N^nd-3 (Shellenbarger and Mohler, 1975) N^spl-1 (Shellenbarger and Mohler, 1975)
Fails to complement	N^24:46A:1 N^30-4 (Lindsley and Zimm, 1992) N^BH9 N^D13 N^D16 N^D30 N^DTV N^264-8 (Slizynska, 1938) N^Ax-tsl (Shellenbarger and Mohler, 1975) N^l1N-ts1 (Shellenbarger and Mohler, 1975) N^l1N-ts2 (Shellenbarger and Mohler, 1975) N^264-39 (Slizynska, 1938)
Comments	Complementation is at 29^oC. (Shellenbarger and Mohler, 1975)
Stocks ( 5 )
Bloomington	45 N^fa-1 4355 y¹ N^fa-1 wy² g²
Kyoto	105697 N^fa-1 101262 y² sc¹ w^a w^ch N^fa-1 101267 y² su(w^a)^* w^a w^ch N^fa-1
Notes on Origin
Discoverer	Bridges, Feb. 1914.

Comments
	N^fa-1 appears to act cell autonomously. (Markopoulou and Artavanis-Tsakonas, 1991)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	fa (Gorman and Girton, 1992, Markopoulou and Artavanis-Tsakonas, 1991, Rabinow and Birchler, 1990, Kelley et al., 1987, Grimwade et al., 1985, Artavanis-Tsakonas et al., 1983, Shellenbarger and Mohler, 1975, Welshons, 1974, Welshons, 1965, Slizynska, 1938, Glass, 1933) fa¹ N^fa-1
Name Synonym	facet (Meyer, 1952, Lewis, 1945)
Secondary FlyBase IDs

References ( 21 )

Generate a list of	All references relating to this allele ( 21 )

List References by type	Research paper ( 18 ) Abstract ( 1 ) Book ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2006 Show research papers ...

Allele Dmel\Nfa-1

Allele Dmel\N^fa-1