|Feature type||allele||Associated gene||Dmel\N|
|Also Known As||faswb|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
800bp deletion removing the 3' part of the gene immediately upstream of N and almost all of the sequences up to the N transcription start site.
A complex event involving 2 deletions that result in a 880bp deletion at the distal end of N.
0.8kb deletion between coordinates -27.3 and -26.0 (zero coordinate is defined as the centre of the 2.2kb EcoRI fragment that encompasses the N76b8 inversion breakpoint).
0.8 kb deletion in -28.4 to -27.1 Caused by a deficiency of 800 base pairs in the restriction fragment -- 26.2 to -- 25.0 (Grimwade, Muskavitch, Welshons, Yedvobnick and Artavanis-Tsakonas, 1985; this is 67 base pairs upstream from the start of transcription of Notch. Deletes the 3' end of the locus immediately to the left of N (Kidd, Kelley and Young, 1986).
|Caused by aberration|
Deficiency for interband between 3C6 and 7, causing these bands to fuse (Keppy and Welshons, 1977).
|Phenotype Manifest In|
Differentiation of primary pigment cells varies between ommatidia.
Disrupted transverse rows of bristles on the first tarsal segments, few extra sex cob bristles and rough eyes.
Homozygotes exhibit rough eyes.
Phenotype is similar to Nfa-g; flies have rough, glossy eyes. The eye phenotype is less mutant in homozygous females than hemizygous males. Nfa-swb/Nfa-g flies have rough eyes that are not glossy.
In males, eyes are rough with a variable tendency to be glossy; with Nfa-g and Nfa-g62, eyes are very rough, but mutant condition is not as extreme as that found in homozygous glossy-eyed mutants. In heterozygotes with Nfa-1, eyes are slightly rough, overlapping wild type; with spl, the eyes are wild type. The Nfa-swb allele, like Nfa-1, is not dosage compensated and the mutant condition is poorly expressed in females. Nfa-swb/Nnd-3 has slight deltas at junction of longitudinal veins with marginal veins; in heterozygotes of Nfa-swb, N55e11 and N264-40, the eyes are glossy and the Notch phenotype is enhanced, resulting in reduced viability and fertility; with the temperature-sensitive N60g11, heterozygotes are less mutant, viable, and fertile. In double mutants, Nfa-swb Nfa-g, the males have Nfa-g-like eyes; and wing veins are thickened and δ like at tips; they resemble Nnd-3 males except that wings are seldom notched. The wing-venation effect is less extreme in homozygous females (Welshons and Keppy, 1975; Keppy and Welshons, 1977). Removal of the region of 3C2-5 from the vicinity of Nfa-swb, either by deletion or inversion results in suppression of Nfa-swb; also affected by spontaneously arising, cis-acting enhancer e(fa<up>swb)</up> and suppressor su(fa<up>swb)</up> mutations, both of which map to the 3C2-5 region. (Welshons and Welshons, 1986).
|Phenotype Manifest In|
The phenotype is enhanced by e(faswb)1; e(faswb)1 in cis with Nfa-swb in either the homozygous or hemizygous condition produces flies with darkly pigmented, very rough, slightly narrow eyes. In addition there is a proliferation of microchaetae over the thorax, abdomen and legs, and the tibiae of the rear legs are distinctly bowed. The phenotype is suppressed by su(faswb)1 in cis with Nfa-swb in either the homozygous or hemizygous condition. The phenotype is also suppressed by In(1)78b.
|Complementation & Rescue Data|
|Not rescued by|
|Stocks ( 1 )|
|Notes on Origin|
Lefevre and Kelley.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 5 )|
|Secondary FlyBase IDs|
|References ( 18 )|
|Personal communication to FlyBase|