Allele Dmel\N^spl-1

General Information
Symbol	Dmel\N^spl-1	Species	D. melanogaster
Name		FlyBase ID	FBal0012900
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\N

Allele class	antimorph, hypomorph, gain of function
Mutagen
Nature of the Allele
Allele class	antimorph (de Celis and Garcia-Bellido, 1994) hypomorph (Brennan et al., 1997) gain of function (Hing et al., 1999)
Mutagen
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: I578T. This replacement is within EGF-like repeat 14 of the N extracellular domain. (Lieber et al., 1992) A missense mutation in the extracellular EGF-like domain. (Ramos et al., 1989) Mutation affecting the extracellular domain of N. (Xu et al., 1990) An amino acid replacement in the 14th EGF-like repeat (FBrf0046120, FBrf0045770). (Rabinow and Birchler, 1990) Substitution of an isoleucine for a threonine in EGF-repeat number 14. (Baker et al., 1990) I to T substitution in the 14th EGF like repeat of the N protein. (Gorman and Girton, 1992) An amino acid replacement in the EGF-homologous regions of the extracellular domain of the N protein. (de Celis et al., 1991) Point mutation in EGF repeat 14. (Brennan et al., 1997)
Assay mode
Carried on aberration	Dp(1;1)Gr
Cytology	Polytene chromosomes normal. (Lindsley and Zimm, 1992)
Phenotypic Data
Phenotypic Class
	viable (Cagan and Ready, 1989) visible (Rabinow and Birchler, 1990, Rollins et al., 1999, Ramain et al., 2001, Cicak and Oster, 1957, Jones et al., 2006) visible \| recessive (Mari-Beffa et al., 1991, Ramos et al., 1989, Cagan and Ready, 1989, Nagel and Preiss, 1999, Lindsley and Zimm, 1992, Held, 1990, Alton et al., 1989, Knust et al., 1987, Lewis, 1945, Shepard et al., 1989, Meyer, 1952, Shellenbarger and Mohler, 1975, Gorman and Girton, 1992) visible \| recessive \| conditional - heat sensitive (Foster, 1973, Lindsley and Zimm, 1992) visible \| dominant (Lai et al., 1998, Campos-Ortega and Knust, 1990) visible \| dominant \| neurogenic (Brennan et al., 1997) cell death increase \| somatic clone (Li et al., 2003)
Phenotype Manifest In
	eye (Li et al., 2003, Hing et al., 1999, Cagan and Ready, 1989, Campos-Ortega and Knust, 1990, Nagel and Preiss, 1999, Lindsley and Zimm, 1992, Rabinow and Birchler, 1990, Xu et al., 1990, Rollins et al., 1999, Lewis, 1945, Shepard et al., 1989, Shellenbarger and Mohler, 1975, Cicak and Oster, 1957, Jones et al., 2006) interommatidial bristle (Lai et al., 1998, Jones et al., 2006) interommatidial bristle \| ectopic (Lai et al., 1998) macrochaeta (Hing et al., 1999, de Celis and Garcia-Bellido, 1994, Lindsley and Zimm, 1992, Rabinow and Birchler, 1990, Rollins et al., 1999, Meyer, 1952, Shellenbarger and Mohler, 1975, Cicak and Oster, 1957) ommatidial cluster (Cagan and Ready, 1989) microchaeta (de Celis and Garcia-Bellido, 1994, Nagel and Preiss, 1999, Ramain et al., 2001) wing \| conditional - heat sensitive (Foster, 1973) tarsal segment \| conditional - heat sensitive (Foster, 1973) eye \| conditional - heat sensitive (Foster, 1973) ommatidium \| conditional - heat sensitive (Foster, 1973) macrochaeta \| conditional - heat sensitive (Foster, 1973) ommatidium (Campos-Ortega and Knust, 1990, Nagel and Preiss, 1999, Shellenbarger and Mohler, 1975, Jones et al., 2006) eye photoreceptor cell (Campos-Ortega and Knust, 1990) dorsocentral bristle (Nagel and Preiss, 1999) tormogen cell (Nagel and Preiss, 1999) mesothoracic tarsal bristle (Held, 1990) mesothoracic leg sensillum (Held, 1990) mesothoracic tarsal segment 1 (Held, 1990) adult thoracic sensillum (Brennan et al., 1997) chaeta (Xu et al., 1990) eye \| somatic clone (Li et al., 2003) ommatidium \| somatic clone (Li et al., 2003) photoreceptor cell R7 \| ectopic \| somatic clone (Li et al., 2003) photoreceptor cell R8 \| somatic clone (Li et al., 2003) macrochaeta \| ectopic (Shellenbarger and Mohler, 1975) microchaeta \| ectopic (Shellenbarger and Mohler, 1975) ocellar bristle (Shellenbarger and Mohler, 1975) supraalar bristle (Shellenbarger and Mohler, 1975) presutural bristle (Shellenbarger and Mohler, 1975) eye \| male (Li and Baker, 2004) photoreceptor cell R8 & eye disc \| male (Li and Baker, 2004) ommatidium & eye disc \| male (Li and Baker, 2004) photoreceptor cell & eye disc \| male (Li and Baker, 2004)
Detailed Description
	Statement Reference Homozygotes have rough eyes. (Lewis, 1945) The split phenotype becomes dominant if N^spl-1 is coupled, in cis, to lethal Ax alleles. When N^spl-1 is coupled to a N point mutant, as in N^64d6,N^spl-1/++; E(spl)¹/+, the phenotype is not split. (Welshons, 1971) Hemizygotes and homozygotes have reduced eyes with an irregular facet arrangement, and missing or doubled bristles are frequently seen. N^264-103/N^spl-1 flies show wing nicking and tarsal segment fusion phenotypes and also show the N^spl-1 eye phenotype. The mutant eye and wing phenotypes are more strongly expressed at high temperatures than low temperatures, and tarsal fusion only occurs at high temperatures. At 20-22^oC, the eyes approach wild type but usually contain small, irregularly positioned areas of facet disarray, while at 28-29^oC the facet disarray extends over the whole surface of the eye. The temperature sensitive periods of these phenotypes occur during the third larval instar stage. (Foster, 1973) Homozygous have small eyes with a rough, pebbly surface. Some bristles are doubled, while others, such as the ocellar, supraalar and presutural bristles are missing, and some extra hairs are present. These phenotypes are the same at 18, 25 and 29^oC. (Shellenbarger and Mohler, 1975) The split phenotype becomes dominant if N^spl-1 is coupled, in cis, to lethal Ax alleles. (Kelley et al., 1987) Homozygotes and hemizygotes develop small and rough compound eyes. Some macrochaetae are split or completely missing. The presence of one copy of E(spl)¹ causes N^spl-1 to acquire a dominant phenotypic expression in all its traits. Dp(3;3)Su⁸ exerts a slight enhancing effect of the N^spl-1 phenotype. (Knust et al., 1987) Dp(2;Y)G44 males crossed to a stock carrying N^spl-1 produce sons that have straight wings or curly wings. Curly wings result from trisomy for the 44C--50B region: enhance the mutant effect of N^spl-1. (Birchler, 1988) Adult eyes rough, slightly reduced, with irregular facets and multiple setae. Irregular size, shape and composition of ommatidia: fewer than normal rhabdomeres per ommatidium. Eye disc pattern, shape and size irregular. (Renfranz and Benzer, 1989) Haploabnormal wing phenotype. (Alton et al., 1989) Early ommatidia in homozygous third instar discs are often poorly arranged and contain an abnormal number of cells. Rarely a single photoreceptor cell is found, and mitotic figures occasionally occur abnormally close to the furrow. By midpupation ommatidia often contain abnormal numbers of photoreceptors, cone cells and secondary pigment cells. Bristles are scattered and photoreceptors can be found beneath the retina. The eye is smaller than normal. Temperature shifts of third-instar N^l1N-ts1 larvae phenocopy the external defects of N^spl-1. (Cagan and Ready, 1989) Heterozygoutes have rough eyes. Hemizygotes show a more extreme reduction in eye size than homozygotes as well as an increase in facet and bristle abnormalities. N^spl-1/Y; E(spl)¹/+ flies show a very extreme mutant phenotype. (Shepard et al., 1989) Small rough eyes and duplicated bristles. (Xu et al., 1990) Homozygotes have small rough eyes due to reduced number of facets and twinned or missing bristles (FBrf0049795). Eye phenotype can be suppressed by sca and enhanced by extra copies of sca⁺ and vg⁺, the bristle phenotype is unaffected. (Rabinow and Birchler, 1990) Pronounced eye phenotype. Does not interact with dx^ENU. (Xu and Artavanis-Tsakonas, 1990) Homozygotes and hemizygotes have rough eyes which are slightly reduced in size compared to wild-type. Individual ommatidia are missing and ommatidia often contain fewer photoreceptor cells than normal and have defects in other ommatidial cell types. Photoreceptor cell axons appear normal. (Campos-Ortega and Knust, 1990) The total number of bristles on the basitarsi of the second legs is increased and the number of sensilla is decreased. A number of shaftless, misshapen sockets are seen. (Held, 1990) Eye discs contain well-spaced clusters of cells with apically disposed nuclei, the number and arrangement of the cells is grossly abnormal. More than one boss-expressing cell was observed within many clusters. Prior to row 6 many cells per cluster contain boss-immunoreactive multivesicular bodies, boss is internalized as soon as boss expression is present on an adjacent cell surface. This correlates with a decrease in the number of R1-R6 neurons and an increase in the number of R7 neurons. (van Vactor et al., 1991) Phenotypes have topographic pattern specificities. Homozygotes show duplications and absence of trichogens preferentially in posterior and medial regions of the tergites. (Mari-Beffa et al., 1991) Individuals homozygous for Bpt¹ and N^spl-1 exhibit no Bpt¹ phenotype and an enhanced spl phenotype. (Duus et al., 1992) N^spl-1 heterozygotes have essentially wild-type eyes. N^spl-1 heterozygotes also carrying Egfr^E3 or Egfr^E1 have rougher eyes. Hemizygous N^spl-1 animals homozygous for Egfr^E3 or Egfr^E1 have almost no facets, the eyes being composed almost entirely of pigment cells and bristles. (Baker and Rubin, 1992) Small rough eyes and missing or doubled bristles. (Gorman and Girton, 1992) Clones mutant for spl on the thorax display a loss of function phenotype: more bristles are formed. (Heitzler and Simpson, 1993) N^M/N^spl-1 flies have roughened eyes which are smaller than normal and split bristles. (Cicak and Oster, 1957) N^68j/N^spl-1 flies have a N^spl-1 phenotype. (Hayman and Maddern, 1969) N⁴⁷ⁱ/N^spl-1 flies have a bristle phenotype but not a roughened eye phenotype. No phenotype is seen in N^51d/N^spl-1 flies. (Meyer, 1952) Eyes rough and small. Many bristles doubled, sometimes missing. Bristle effect caused by an extra division of initial bristle-forming cell (FBrf0005804). Few bristles (but not their sockets) regularly removed from posterior border of tergites in N^spl-1/+ heterozygotes (Welshons). N^64d6 N^spl-1 flies cannot be distinguished from N^64d6/+ flies. When N^spl-1 is coupled to N^64d6, N^spl-1 is not enhanced by E(spl)¹. A temperature-sensitive effect is shown by N^264-103/N^spl-1 flies, which have abnormal eye facets at 28-29^oC but are almost wild type at 20-22^oC. The spl phenotype can be enhanced by E(spl)¹/+ or E(spl)¹/E(spl)¹. N^spl-1/+;E(spl)¹/+ flies resemble N^spl-1/N^spl-1 flies; N^spl-1/N^spl-1; E(spl)¹/+ and N^spl-1/Y;E(spl)¹/+ flies show a very extreme mutant phenotype. N^spl-1/Y; gro^E73/+ males and N^spl-1/+; gro^E73/+ females show spl and Ax-like phenotypes (Xu et al.). The spl phenotype is reduced in mam heterozygotes. When, however, N^spl-1 is coupled to a N point mutant, as in N^64d6 N^spl-1/++; E(spl)¹/+, the phenotype is not spl. The N^spl-1 phenotype becomes dominant if N^spl-1 is coupled, in cis, to lethal Ax alleles. RK1. (Lindsley and Zimm, 1992) Macrochaetae and microchaetae lost or affected by abnormal differentiation are those that are most sensitive to Abruptex mutants. In combination with a N null allele, N^spl-1 causes extra macrochaetae and microchaetae. In presence of a N duplication, the mutant phenotype is reduced but not suppressed. (de Celis and Garcia-Bellido, 1994) Eye size of N^spl-1 is increased in males that are homozygous for mle⁴. (Hiebert and Birchler, 1994) Increase in microchaetae density in the mesonotum when in combination with N amorph alleles and absence of macrochaetae when homozygote. (de Celis et al., 1991) Heterozygotes have a neurogenic phenotype and have an increase in the number of thoracic bristles compared to wild-type. The number of bristles is restored almost to wild-type in N^spl-1; Dp(1;2)51b double heterozygotes. (Brennan et al., 1997) Heterozygous females have largely wild-type eyes, although missing or double interommatidial bristles are sometimes seen. (Lai et al., 1998) Dorsocentral bristles appear split due to a duplication of the bristle shaft at the expense of the socket cell. Conversely, at the back of the head, double sockets appear instead of microchaetae. Homozygous females have smaller eyes of rough appearance due to irregular spacing of ommatidia. (Nagel and Preiss, 1999) Small rough eyes, twinned bristles and missing bristles. (Rollins et al., 1999) Homozygotes show small rough eyes and split bristles. (Hing et al., 1999) Mutant flies have 120.22 +/- 1.34 thoracic microchaetae per heminotum (compared to the wild-type number of 130.35 +/- 1.54). (Ramain et al., 2001) When N^spl-1 clones are made in the developing eye, animals have fewer ommatidia and ommatidia with less than the normal complement of differentiated cells. Cell death is increased in mutant eyes. Many R8 precursors are absent. In about 13% of ommatidia with N^spl-1 clones ectopic R7 photoreceptor cells are seen. (Li et al., 2003) Mutants have a reduced, rough eye with missing or double bristles. (Jones et al., 2006) Hemizygous N[spl-1] males have small, rough eyes. Some R8 cells and ommatidia are missing, while other ommatidia have abnormal R8 cells and lack other photoreceptor cells in N[spl-1]/Y eye imaginal discs. (Li and Baker, 2004)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference N^spl-1 has visible phenotype, enhanceable by E(spl)[+]/E(spl)¹ (Shepard et al., 1989) N^spl-1 has visible \| dominant phenotype, enhanceable by E(spl)¹ (Nagel and Preiss, 1999) N^spl-1 has visible phenotype, enhanceable by E(spl)¹ (Campos-Ortega and Knust, 1990) E(spl)¹, N^spl-1 has visible \| dominant phenotype, enhanceable by ato⁵ (Nagel and Preiss, 1999) E(spl)¹, N^spl-1 has visible \| dominant phenotype, enhanceable by ato³ (Nagel and Preiss, 1999) E(spl)¹, N^spl-1 has visible \| dominant phenotype, enhanceable by da⁵ (Nagel and Preiss, 1999) E(spl)¹, N^spl-1 has visible \| suppressible phenotype, enhanceable by sca^unspecified (Nagel and Preiss, 1999) N^spl-1 has visible \| dominant phenotype, enhanceable by E(spl)^K:CAACdel (Lai et al., 1998) N^spl-1 has visible \| dominant phenotype, enhanceable by E(spl)^K1K2mut (Lai et al., 1998) N^spl-1 has visible \| dominant phenotype, enhanceable by Df(3R)Dl-FX3 (Brennan et al., 1997)
NOT Enhanced by
Statement Reference N^spl-1 has visible \| dominant phenotype, non-enhanceable by E(spl)^tLa (Lai et al., 1998)
Suppressed by
Statement Reference E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^BE21/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl[+]/Dl^BE23 (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^BE24/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^BE26/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^BE32/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^BE35/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^BX40/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl[+]/Dl^BX41 (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl[+]/Dl^BX43 (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^BX45/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^BX46/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl[+]/Dl^CE21 (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^CE23/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^CE33/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^CE34/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl^CE37/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, suppressible by Dl[+]/Dl^CE43 (Shepard et al., 1989) N^spl-1 has visible phenotype, suppressible by dsh^hs.PA (Ramain et al., 2001) N^spl-1 has visible \| recessive phenotype, suppressible by Gp150[+]/Gp150^k11120b (Li et al., 2003) N^spl-1 has visible \| dominant phenotype, suppressible by wg^S107 (Brennan et al., 1997) N^spl-1 has visible phenotype, suppressible by snama^PX1/mnm[+] (Jones et al., 2006) N^spl-1 has visible phenotype, suppressible by l(2)rQ313[+]/snama^rQ313 (Jones et al., 2006)
NOT suppressed by
Statement Reference E(spl)[+]/E(spl)¹, N^spl-1 has visible phenotype, non-suppressible by Dl^HD82/Dl[+] (Shepard et al., 1989)
Other
Statement Reference N^spl-1, sno¹ has lethal phenotype (Lefevre and Peterson, 1972, Lefevre and Peterson, 1972)
Phenotype Manifest In
Enhanced by
Statement Reference N^spl-1 has eye phenotype, enhanceable by E(spl)[+]/E(spl)¹ (Shepard et al., 1989) N^spl-1 has eye phenotype, enhanceable by E(spl)^1.Scer\UAS/Scer\GAL4^h-1J3 (Nagel et al., 1999) N^spl-1 has eye phenotype, enhanceable by E(spl)::HLHmδ^cNa (Nagel et al., 1999) N^spl-1 has eye phenotype, enhanceable by E(spl)::HLHm5^E(spl).PN (Nagel et al., 1999) N^spl-1 has eye phenotype, enhanceable by E(spl)^+t2.8 (Nagel et al., 1999) N^spl-1 has eye phenotype, enhanceable by E(spl)^1.tNa (Nagel et al., 1999) N^spl-1 has eye phenotype, enhanceable by HLHm7^+t5.6 (Nagel et al., 1999) N^spl-1 has phenotype, enhanceable by Df(2R)Nipped-D263.3 (Rollins et al., 1999) N^spl-1 has phenotype, enhanceable by Df(2R)Nipped-E43 (Rollins et al., 1999) N^spl-1 has macrochaeta phenotype, enhanceable by Df(2R)Nipped-D341.1 (Rollins et al., 1999) N^spl-1 has macrochaeta phenotype, enhanceable by Df(2R)Nipped-E338 (Rollins et al., 1999) N^spl-1 has phenotype, enhanceable by E(spl)^1.tKa (Tietze et al., 1993) N^spl-1 has eye phenotype, enhanceable by E(spl)¹ (Nagel and Preiss, 1999, Campos-Ortega and Knust, 1990) N^spl-1 has ommatidium phenotype, enhanceable by E(spl)¹ (Nagel and Preiss, 1999, Campos-Ortega and Knust, 1990) N^spl-1 has interommatidial bristle \| ectopic phenotype, enhanceable by E(spl)^K:CAACdel (Lai et al., 1998) N^spl-1 has ommatidium phenotype, enhanceable by E(spl)^K:CAACdel (Lai et al., 1998) N^spl-1 has interommatidial bristle \| ectopic phenotype, enhanceable by E(spl)^K1K2mut (Lai et al., 1998) N^spl-1 has ommatidium phenotype, enhanceable by E(spl)^K1K2mut (Lai et al., 1998) N^spl-1 has photoreceptor cell R8 phenotype, enhanceable by Scer\GAL4^GMR.PF/Dl^Scer\UAS.cLa (Li et al., 2003) N^spl-1 has phenotype, enhanceable by rn[+]/rn^roe-KE17 (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn[+]/rn^roe-KE18 (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn^roe-KE27/rn[+] (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn^roe-KE55/rn[+] (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn[+]/rn^roe-KE100 (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn^roe-KE345/rn[+] (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn^roe-KE405/rn[+] (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn^roe-KEK2/rn[+] (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn^roe-KX314/rn[+] (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn^roe-KE89/rn[+] (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn[+]/rn^roe-KE113 (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn[+]/rn^roe-KE380 (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn^roe-KE399/rn[+] (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn^roe-KE80/rn[+] (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn[+]/rn^roe-KE350 (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn^roe-KE409/rn[+] (Brand and Campos-Ortega, 1990) N^spl-1 has phenotype, enhanceable by rn[+]/rn^roe-KX316 (Brand and Campos-Ortega, 1990) N^spl-1 has adult thoracic sensillum phenotype, enhanceable by Df(3R)Dl-FX3 (Brennan et al., 1997) N^spl-1 has phenotype, enhanceable by E(spl)^rv29 (Ziemer et al., 1988) N^spl-1 has phenotype, enhanceable by E(spl)^rv30 (Ziemer et al., 1988) N^spl-1 has phenotype, enhanceable by E(spl)^rv31 (Ziemer et al., 1988)
NOT Enhanced by
Statement Reference N^spl-1 has eye phenotype, non-enhanceable by E(spl)^Scer\UAS.cGa/Scer\GAL4^h-1J3 (Nagel et al., 1999) N^spl-1 has eye phenotype, non-enhanceable by E(spl)::HLHm5^cNa (Nagel et al., 1999) N^spl-1 has phenotype, non-enhanceable by Chi^e5.5 (Rollins et al., 1999) N^spl-1 has phenotype, non-enhanceable by Nipped-A^222.3 (Rollins et al., 1999) N^spl-1 has phenotype, non-enhanceable by Su(H)⁸ (Rollins et al., 1999) N^spl-1 has phenotype, non-enhanceable by l(2)41Ae⁷ (Rollins et al., 1999) N^spl-1 has phenotype, non-enhanceable by vg¹ (Rollins et al., 1999) N^spl-1 has macrochaeta phenotype, non-enhanceable by Nipped-B^292.1 (Rollins et al., 1999) N^spl-1 has macrochaeta phenotype, non-enhanceable by Su(H)¹⁶ (Rollins et al., 1999) N^spl-1 has eye phenotype, non-enhanceable by Egfr^f3 (Nagel and Preiss, 1999) N^spl-1 has eye phenotype, non-enhanceable by S⁵⁴ (Nagel and Preiss, 1999) N^spl-1 has eye phenotype, non-enhanceable by S^IIN (Nagel and Preiss, 1999) N^spl-1 has eye phenotype, non-enhanceable by hh¹⁸ (Nagel and Preiss, 1999) N^spl-1 has eye phenotype, non-enhanceable by hh²¹ (Nagel and Preiss, 1999) N^spl-1 has eye phenotype, non-enhanceable by hh³ (Nagel and Preiss, 1999) N^spl-1 has eye phenotype, non-enhanceable by wg^l-12 (Nagel and Preiss, 1999) N^spl-1 has eye phenotype, non-enhanceable by wg^l-9 (Nagel and Preiss, 1999) N^spl-1 has interommatidial bristle phenotype, non-enhanceable by E(spl)^tLa (Lai et al., 1998) N^spl-1 has ommatidium phenotype, non-enhanceable by E(spl)^tLa (Lai et al., 1998) N^spl-1 has phenotype, non-enhanceable by E(S)¹ (Lewis, 1945) N^spl-1 has eye phenotype, non-enhanceable by E(spl)^1.Scer\UAS/Scer\GAL4^h-H10 (Bose et al., 2006)
Suppressed by
Statement Reference E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^BE21/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl[+]/Dl^BE23 (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^BE24/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^BE26/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^BE32/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^BE35/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^BX40/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl[+]/Dl^BX41 (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl[+]/Dl^BX43 (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^BX45/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^BX46/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl[+]/Dl^CE21 (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^CE23/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^CE33/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^CE34/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl^CE37/Dl[+] (Shepard et al., 1989) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, suppressible by Dl[+]/Dl^CE43 (Shepard et al., 1989) N^spl-1 has eye phenotype, suppressible by Hsc70-4¹⁹⁵ (Hing et al., 1999) N^spl-1 has macrochaeta phenotype, suppressible by Hsc70-4¹⁹⁵ (Hing et al., 1999) N^spl-1 has phenotype, suppressible by Su(spl)^KE7 (Hu et al., 1995, Mlodzik et al., 1990) N^spl-1 has microchaeta phenotype, suppressible by dsh^hs.PA (Ramain et al., 2001) N^spl-1 has eye phenotype, suppressible by mam¹⁰/mam[+] (Xu et al., 1990) N^spl-1 has chaeta phenotype, suppressible by mam¹⁰/mam[+] (Xu et al., 1990) N^spl-1 has eye phenotype, suppressible by mam^88-4/mam[+] (Xu et al., 1990) N^spl-1 has chaeta phenotype, suppressible by mam^88-4/mam[+] (Xu et al., 1990) N^spl-1 has eye phenotype, suppressible \| partially by mam^88-10/mam[+] (Xu et al., 1990) N^spl-1 has chaeta phenotype, suppressible \| partially by mam^88-10/mam[+] (Xu et al., 1990) N^spl-1 has phenotype, suppressible by Df(2R)Nipped-D263.3 (Rollins et al., 1999) N^spl-1 has eye phenotype, suppressible by Df(2R)Nipped-D341.1 (Rollins et al., 1999) N^spl-1 has eye phenotype, suppressible by Df(2R)Nipped-E338 (Rollins et al., 1999) N^spl-1 has eye phenotype, suppressible by Nipped-B^292.1 (Rollins et al., 1999) N^spl-1 has eye phenotype, suppressible by Nipped-B⁴⁰⁷ (Rollins et al., 1999) N^spl-1 has eye phenotype, suppressible by Nipped-A³²³ (Rollins et al., 1999) N^spl-1 has eye phenotype, suppressible by RpL38^45-72 (Rollins et al., 1999) N^spl-1 has eye phenotype, suppressible by Su(H)¹⁶ (Rollins et al., 1999) N^spl-1 has phenotype, suppressible by E(nd)195^ry+3550 (Hing and Artavanis-Tsakonas, 1995) N^spl-1 has phenotype, suppressible by sca^KE15 (Mlodzik et al., 1990) N^spl-1 has phenotype, suppressible by sca^KE17 (Mlodzik et al., 1990) N^spl-1 has phenotype, suppressible by sca^KE305 (Mlodzik et al., 1990) N^spl-1 has phenotype, suppressible by sca^KE3 (Mlodzik et al., 1990) N^spl-1 has phenotype, suppressible by sca^KX2 (Mlodzik et al., 1990) N^spl-1 has eye phenotype, suppressible by Gp150[+]/Gp150^k11120b (Li et al., 2003) N^spl-1 has phenotype, suppressible by Dl^sup4 (Lieber et al., 1992) N^spl-1 has phenotype, suppressible by Dl^sup5 (Lieber et al., 1992) N^spl-1 has adult thoracic sensillum phenotype, suppressible by wg^S107 (Brennan et al., 1997) N^spl-1 has eye phenotype, suppressible by snama^PX1/mnm[+] (Jones et al., 2006) N^spl-1 has ommatidium phenotype, suppressible by snama^PX1/mnm[+] (Jones et al., 2006) N^spl-1 has eye phenotype, suppressible by l(2)rQ313[+]/snama^rQ313 (Jones et al., 2006) N^spl-1 has ommatidium phenotype, suppressible by l(2)rQ313[+]/snama^rQ313 (Jones et al., 2006)
NOT suppressed by
Statement Reference N^spl-1 has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968) E(spl)[+]/E(spl)¹, N^spl-1 has eye phenotype, non-suppressible by Dl^HD82/Dl[+] (Shepard et al., 1989) N^spl-1 has phenotype, non-suppressible by Chi^e5.5 (Rollins et al., 1999) N^spl-1 has phenotype, non-suppressible by Nipped-A^222.3 (Rollins et al., 1999) N^spl-1 has phenotype, non-suppressible by Su(H)⁸ (Rollins et al., 1999) N^spl-1 has phenotype, non-suppressible by l(2)41Ae⁷ (Rollins et al., 1999) N^spl-1 has phenotype, non-suppressible by vg¹ (Rollins et al., 1999) N^spl-1 has phenotype, non-suppressible by Nipped-A^394.2 (

Allele Dmel\Nspl-1

Allele Dmel\N^spl-1