|Feature type||allele||Associated gene||Dmel\ncd|
|Also Known As||ncd|
|Map ( GBrowse )|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: G446R. Amino acid replacement: A566S. Amino acid replacement: G696A. G446R change affects a highly conserved glycine residue in the ATP-binding region, A566S is a conservative amino acid change and G696A is outside the motor domain.
no 2.6 kb deletion
|Phenotype Manifest In|
meiosis & nuclear chromosome & oocyte
Most of the meiotic exceptions result from chromosome loss. Frayed and monopolar spindles are frequently observed.
Approximately 90% of eggs laid by homozygous females fail to hatch.
Homozygous females show increased chromosome nondisjunction and loss compared to wild-type. Embryos derived from homozygous females have reduced viability. The chromosome missegregation phenotype is fully rescued in heterozygous females but embryo viability is only partially rescued.
Homozygous oocytes show abnormal chromosome behaviour in meiosis. Bivalents segregating in different directions are seen in anaphase I.
|Phenotype Manifest In|
The ncd2 inviability is dominantly enhanced by γTub37C13 or γTub37C12; ncd2 females heterozygous for γTub37C13 or γTub37C12 lay eggs but more than 99% fail to hatch.
|Complementation & Rescue Data|
|Fails to complement|
|Partially rescued by|
ncd2/ncd2 females carrying two copies of ncd2.T:Avic\GFP-S65T have poor fertility, high egg inviability and elevated chromosome missegregation. ncd2/+ females carrying one copy of ncd2.T:Avic\GFP-S65T are completely rescued for chromosome segregation but partially rescued for embryo viability.
recovered as ca+
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 9 )|