A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\net1

General Information
SymbolDmel\net1SpeciesD. melanogaster
NameFlyBase IDFBal0012933
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\net
Allele classloss of function
Mutagenspontaneous
hide Nature of the Allele
Allele class
loss of function
(Brentrup et al., 2000)
Mutagen
spontaneous
 
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      244bp duplication between nucleotide position 1105 and 1106 (corresponding to a position between amino acids 277 and 278 of the wild type sequence) with the preceding 244bp duplicated.
      (Brentrup et al., 2000)
      Assay mode
      Carried on aberration
      Df(2L)BSC4
      (Deal and Cook, 2001.4.24)
      Df(2L)BSC52
      (Deal and Cook, 2004.5.27)
      Df(2L)BSC16
      (Deal and Cook, 2002.7.14)
      Df(2L)BSC31
      (Deal and Cook, 2003.4.2)
      Df(2L)BSC51
      (Deal and Cook, 2004.5.27)
      In(2L)Cy
      (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      visible
      (Verheyen et al., 2001)
      visible | recessive
      (Brentrup et al., 2000, Baonza and Garcia-Bellido, 1999)
      hide Phenotype Manifest In
      wing vein
      (Verheyen et al., 2001, Baonza and Garcia-Bellido, 1999)
      wing vein | ectopic
      (Brentrup et al., 2000, Marenda et al., 2004)
      hide Detailed Description
      Statement
      Reference
      Wing veins form plexus-like net; first posterior cell between L3 and L4 widens toward tip; branch missing from posterior crossvein; all veins fused at base of wing, like bi. According to Waddington (1940), spaces form between epithelial layers owing to inadequate contraction during pupal period; spaces later fuse and form extra veins (Diaz-Benjumea, Gonzalez-Gaitan, and Garcia-Bellido, 1989). RK1.
       
      Appearance of distal extra longitudinal veins preferentially associated with plexi between LII and LIII on one side and between LIV and LV on the other.
      (Diaz-Benjumea and Garcia-Bellido, 1990)
      Homozygotes have extra wing veins.
      (Baonza and Garcia-Bellido, 1999)
      Homozygotes show ectopic wing veins and plexi.
      (Brentrup et al., 2000)
      Heterozygotes have essentially normal wings, occasionally having a single extra vein near the posterior crossvein (3%).
      (Marenda et al., 2004)
      hide Interactions
      hide Phenotypic Class
      hideEnhanced by
      Statement
      Reference
      net1 has visible phenotype, enhanceable by nmoadk2
      (Verheyen et al., 2001)
      net1 has visible | recessive phenotype, enhanceable by emc1/emc[+]
      (Baonza and Garcia-Bellido, 1999)
      hideSuppressed by
      Statement
      Reference
      net1 has visible | recessive phenotype, suppressible by emcD
      (Baonza and Garcia-Bellido, 1999)
      hideEnhancer of
      Statement
      Reference
      net1 is an enhancer of visible phenotype of nmoadk2
      (Verheyen et al., 2001)
      net1/net[+] is an enhancer of visible | conditional - heat sensitive phenotype of HC2.hs
      (Johannes and Preiss, 2002)
      hideOther
      Statement
      Reference
      HC2.hs, net1 has semi-lethal | conditional - heat sensitive phenotype
      (Johannes and Preiss, 2002, Johannes and Preiss, 2002)
      emc1/emc11, net1 has visible | dominant phenotype
      (Baonza and Garcia-Bellido, 1999)
      emc1/emc11, net1 has visible phenotype
      (Baonza and Garcia-Bellido, 1999)
      hide Phenotype Manifest In
      hideEnhanced by
      Statement
      Reference
      net1 has wing vein phenotype, enhanceable by nmoadk2
      (Verheyen et al., 2001)
      net1 has wing vein | ectopic phenotype, enhanceable by emc1/emc[+]
      (Baonza and Garcia-Bellido, 1999)
      net1 has wing vein | ectopic phenotype, enhanceable by Df(1)C246/+
      (Marenda et al., 2004)
      net1 has wing vein | ectopic phenotype, enhanceable by Df(3L)ZN47
      (Marenda et al., 2004)
      net1 has wing vein | ectopic phenotype, enhanceable by Rpd304556/Rpd3[+]
      (Marenda et al., 2004)
      net1 has wing vein | ectopic phenotype, enhanceable by Snr1E1/Snr1[+]
      (Marenda et al., 2004)
      net1 has wing vein | ectopic phenotype, enhanceable by mor[+]/mor1
      (Marenda et al., 2004)
      net1 has wing vein | ectopic phenotype, enhanceable by osa2/osa[+]
      (Marenda et al., 2004)
      net1 has wing vein | ectopic phenotype, enhanceable by Snr1R3/Snr1[+]
      (Marenda et al., 2004)
      hideNOT Enhanced by
      Statement
      Reference
      net1 has wing vein | ectopic phenotype, non-enhanceable by brm[+]/brm2
      (Marenda et al., 2004)
      net1 has wing vein | ectopic phenotype, non-enhanceable by osa00090/osa[+]
      (Marenda et al., 2004)
      hideSuppressed by
      Statement
      Reference
      net1 has wing vein | ectopic phenotype, suppressible by emcD
      (Baonza and Garcia-Bellido, 1999)
      hideNOT suppressed by
      Statement
      Reference
      net1 has phenotype, non-suppressible by su(Hw)2
      (Lindsley and Grell, 1968)
      net1 has wing vein | ectopic phenotype, non-suppressible by brm[+]/brm2
      (Marenda et al., 2004)
      net1 has wing vein | ectopic phenotype, non-suppressible by osa00090/osa[+]
      (Marenda et al., 2004)
      hideEnhancer of
      Statement
      Reference
      net1 is an enhancer of wing vein phenotype of nmoadk2
      (Verheyen et al., 2001)
      net1/net[+] is an enhancer of wing vein | ectopic phenotype of Snr1E1
      (Marenda et al., 2004)
      net1/net[+] is an enhancer of wing vein | ectopic | conditional - heat sensitive phenotype of HC2.hs
      (Johannes and Preiss, 2002)
      net1/net[+] is an enhancer of wing | conditional - heat sensitive phenotype of HC2.hs
      (Johannes and Preiss, 2002)
      hideOther
      Statement
      Reference
      emc1/emc11, net1 has wing vein | ectopic phenotype
      (Baonza and Garcia-Bellido, 1999)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      The extra wing vein phenotype of net1 homozygotes is suppressed by emcD and enhanced by emc1/+. net1/+ ; emc1/emc11 flies show an extra wing vein phenotype.
      (Baonza and Garcia-Bellido, 1999)
      net1 nmoadk2 double mutant flies show a strong synergistic interaction with respect to the extra wing vein phenotype of each single mutant.
      (Verheyen et al., 2001)
      net ; HC2.hs homozygotes are semi-lethal at 25oC (and viable at 18oC). The animals have massive patches of vein tissue and extensive blistering of the wing.
      (Johannes and Preiss, 2002)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Fails to complement
      net4
      (Meyer, 1956)
      Partially rescued by
      net1 is partially rescued by netScer\UAS.cBa/Scer\GAL4Bx-MS1096
      (Brentrup et al., 2000)
      Comments
      hide Stocks ( 23 )
      Bloomington
      354
      net1
      356
      net1 ed1 Su(dx)2
      8470
      Df(2L)BSC51, net1 cn1/SM5
      8471
      Df(2L)BSC52, net1 cn1/SM5
      5491
      net1 cn1 Hsf1/CyO
      6608
      Df(2L)BSC16, net1 cn1/SM6a
      5933
      net1 b1 cn1 sp1
      6283
      Df(2L)BSC4, w+mC, net1 cn1/SM5
      Kyoto
      105868
      net1
      105870
      net1 ed1 Su(dx)2
      108257
      net1 cn1 Hsf1/CyO
      108848
      Df(2L)BSC16, net1 cn1/SM6a
      hide Notes on Origin
      Discoverer
      Bridges, 10th March 1931.
      hide Synonyms & Secondary IDs ( 2 )
      Reported As
      Symbol Synonym
      net1
       
      unnamed
      (Roote, 2004.6.24)
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 17 )
        Research paper
        Marenda et al., 2004, Dev. Biol. 267(2): 279--293
        The Drosophila Brahma (SWI/SNF) chromatin remodeling complex exhibits cell-type specific activation and repression functions. [FBrf0174517]
        Johannes and Preiss, 2002, Mech. Dev. 115(1-2): 3--14
        Wing vein formation in Drosophila melanogaster: hairless is involved in the cross-talk between Notch and EGF signaling pathways. [FBrf0149093]
        Verheyen et al., 2001, Mech. Dev. 101(1-2): 119--132
        The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development. [FBrf0134745]
        Brentrup et al., 2000, Development 127(21): 4729--4741
        Regulation of Drosophila wing vein patterning: net encodes a bHLH protein repressing rhomboid and is repressed by rhomboid-dependent Egfr signalling. [FBrf0129742]
        Firth et al., 2000, Genetics 156(2): 733--748
        Identification of genomic regions that interact with a viable allele of the Drosophila protein tyrosine phosphatase corkscrew. [FBrf0129810]
        Baonza and Garcia-Bellido, 1999, Mech. Dev. 80(2): 133--146
        Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila. [FBrf0107601]
        Diaz-Benjumea and Garcia-Bellido, 1990, Roux Arch. dev. Biol. 198(6): 336--354
        Genetic analysis of the wing vein pattern of Drosophila. [FBrf0052918]
        Meyer, 1956, D. I. S. 30: 77
        [New mutants report.] [FBrf0063689]
        Waddington, 1940, J. Genet. 41: 75--139
        The genetic control of wing development in Drosophila. [FBrf0005070]
        Personal communication to FlyBase
        Deal and Cook, 2004.5.27, Isolation and characterization of Df(2L)BSC52.
        Isolation and characterization of Df(2L)BSC52. [FBrf0178873]
        Deal and Cook, 2004.5.27, Isolation and characterization of Df(2L)BSC51.
        Isolation and characterization of Df(2L)BSC51. [FBrf0178872]
        Roote, 2004.6.24, Cam Dps.
        Cam Dps. [FBrf0178882]
        Deal and Cook, 2003.4.2, Isolation and characterization of Df(2L)BSC31.
        Isolation and characterization of Df(2L)BSC31. [FBrf0157306]
        Deal and Cook, 2002.7.14, Isolation and characterization of Df(2L)BSC16.
        Isolation and characterization of Df(2L)BSC16. [FBrf0150855]
        Deal and Cook, 2001.4.24, Isolation and Characterization of Df(2L)BSC4.
        Isolation and Characterization of Df(2L)BSC4. [FBrf0136028]
        Book
        Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp
        Genetic variations of Drosophila melanogaster. [FBrf0020044]
        Stock list
        The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Russia, 1997, D. I. S. 80: 109--130
        Stock list. [FBrf0098381]