Allele Dmel\ninaA²

General Information
Symbol	Dmel\ninaA²	Species	D. melanogaster
Name		FlyBase ID	FBal0012960
Feature type	allele	Associated gene	Dmel\ninaA
Also Known As	ninaA^P263

Map ( GBrowse )
Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Schneuwly et al., 1989)
Mutagen	ethyl methanesulfonate (Schneuwly et al., 1989)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2L:877,620..877,620 evidence=experimental na_change=C877620T pr_change=Q87@\|ninaA-PA reported_na_change=C693T reported_pr_change=Q87@ (Schneuwly et al., 1989)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q87@. (Schneuwly et al., 1989) Nucleotide substitution: C692T. (Schneuwly et al., 1989)
Cytology
Phenotypic Data
Phenotypic Class
	neurophysiology defective (Gu et al., 2004)
Phenotype Manifest In
	photoreceptor cell (Kurada and O'Tousa, 1995)
Detailed Description
	Statement Reference Homozygous flies and mosaic flies in which the retinal tissue is homozygous for ninaA² but the rest of the animal is ninaA⁺ lack the prolonged depolarising afterpotential (PDA) in the electroretinogram response. (Gu et al., 2004) Mutants exhibit excessive endoplasmic reticulum (ER) in photoreceptor cells that is dependent on expression of rhodopsin gene. The ninaE⁺/ninaE^D1 or the ninaE⁺/ninaE^D2 heterozygous genotypes do not prevent the accumulation of ER present in ninaA² flies. (Kurada and O'Tousa, 1995) With respect to defective PDA, ninaA² > ninaA¹ > ninaA³.
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	42261 w^*; ninaA²
Notes on Origin
Discoverer	Pak.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	ninaA² ninaA^P263 (Gu et al., 2004, Kurada et al., 1998, Kurada and O'Tousa, 1995, Schneuwly et al., 1989, Ahmad et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Ahmad et al., 2006, Invest. Ophthalmol. Vis. Sci. 47(9): 3722--3728 Heterologous expression of bovine rhodopsin in Drosophila photoreceptor cells. [FBrf0194158] Gu et al., 2004, J. Biol. Chem. 279(18): 18608--18613 Drosophila ninaB and ninaD act outside of retina to produce rhodopsin chromophore. [FBrf0174785] Kurada et al., 1998, Vis. Neurosci. 15(4): 693--700 Rhodopsin maturation antagonized by dominant rhodopsin mutants. [FBrf0103560] Kurada and O'Tousa, 1995, Neuron 14(3): 571--579 Retinal degeneration caused by dominant rhodopsin mutations in Drosophila. [FBrf0080181] Schneuwly et al., 1989, Proc. Natl. Acad. Sci. U.S.A. 86: 5390--5394 Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein). [FBrf0050847]

Allele Dmel\ninaA2

Allele Dmel\ninaA²