Allele Dmel\ninaE¹

General Information
Symbol	Dmel\ninaE¹	Species	D. melanogaster
Name		FlyBase ID	FBal0013006
Feature type	allele	Associated gene	Dmel\ninaE
Also Known As	ninaE^ora, ora^JK84, ninaE^JK84, ora

Map ( GBrowse )
Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Pollock et al., 1995)
Mutagen	ethyl methanesulfonate
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:15,712,706..15,712,706 evidence=experimental na_change=C15712706T pr_change=Q251@\|ninaE-PA comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. reported_pr_change=Q251\|FBrf0080181,Q251\|FBrf0056239 (Washburn and O'Tousa, 1992, Kurada and O'Tousa, 1995)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q251@. (Washburn and O'Tousa, 1992, Kurada and O'Tousa, 1995) Gln²⁵¹ --> stop
Cytology
Phenotypic Data
Phenotypic Class
	thermotaxis behavior defective \| larval stage \| temperature conditional (Shen et al., 2011)
Phenotype Manifest In
	rhabdomere R1 (Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995) rhabdomere R1 & microvillus (Pollock et al., 1995) rhabdomere R2 (Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995) rhabdomere R2 & microvillus (Pollock et al., 1995) rhabdomere R3 (Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995) rhabdomere R3 & microvillus (Pollock et al., 1995) rhabdomere R4 (Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995) rhabdomere R4 & microvillus (Pollock et al., 1995) rhabdomere R5 (Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995) rhabdomere R5 & microvillus (Pollock et al., 1995) rhabdomere R6 (Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995) rhabdomere R6 & microvillus (Pollock et al., 1995)
Detailed Description
	Statement Reference Mutant larvae show defects in discrimination between 18[o]C and 24[o]C in a binary choice thermotaxis assay compared to controls, but discrimination between 18[o]C and cooler or very warm temperatures is normal. (Shen et al., 2011) The effect of anoxia as measured in the eye by extracellular voltage change recordings is similar to that of wild type. (Agam et al., 2000) The eyelet maintains well-developed rhabdomeres even 1 week after eclosion in mutant flies, although degeneration of ommatidial rhabdomeres R1-R6 is seen. (Yasuyama and Meinertzhagen, 1999) The whole cell capacitance of photoreceptor cells remains relatively small throughout development, in contrast to wild-type. The magnitude of the rundown current (RDC) is larger than wild-type at all developmental stages. R1 to R6 photoreceptor cells have more microvilli per rhabdomere than wild-type flies and membrane loops at the base of the microvilli are enlarged compared to wild-type. (Pollock et al., 1995) Third instar foraging larvae show negative photobehaviour indistinguishable from the wild-type response to light. Third instar larvae continue to show negative phototaxis during the wandering stage, in contrast to wild-type larvae. (Sawin-McCormack et al., 1995) induced with ort¹ as "ora^JK84"; ca 10^-6 normal RH1 level
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference ninaE¹, ort¹ has locomotor behavior defective phenotype (Strauss et al., 2001, Strauss et al., 2001)
Phenotype Manifest In
Suppressor of
Statement Reference ninaE¹ is a suppressor of phenotype of norpA³⁶ (Kurada and O'Tousa, 1995)
Additional Comments
Genetic Interactions
Statement Reference ninaE¹ ort¹ flies show residual object fixation in tethered flight, but no more than 16% of the residual object fixation is accomplished with wingbeat steering (the predominant steering mechanism of normal flies). ninaE¹ ort¹ flies are significantly impaired in the ability to maintain their orientation towards a landmark when walking in the Buridan's paradigm assay. Their average and maximum walking speed are reduced to about one-half of the corresponding speed observed under identical conditions in wild-type flies. (Strauss et al., 2001)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	1946 w^*; ort¹ ninaE¹
Kyoto	106595 w^*; ort¹ ninaE¹
Notes on Origin
Discoverer	Koenig.

Comments
	Photolysis of the caged Ca²⁺ compounds DM-nitrophen and nitr-5 induces a small inward current with no detectable latency in ninaE¹ photoreceptor cells. (Hardie, 1995)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	ninaE¹ (Shen et al., 2011) ninaE^JK84 (Sawin-McCormack et al., 1995, Kurada and O'Tousa, 1995, ) ninaE^ora (Agam et al., 2000, Yasuyama and Meinertzhagen, 1999, Yang et al., 1998, Shim et al., 1997, Lee et al., 1996, Hardie, 1996, Stark et al., 1995, Pollock et al., 1995, Hardie, 1995, ) ninaE^oraJK84 (Arnon et al., 1997) ora (Hardie, 1995, Washburn and O'Tousa, 1992) ora^JK84 (Yasuhara et al., 2000, Kurada et al., 1995) Q251@ (Bentrop, 1998)
Name Synonym
Secondary FlyBase IDs
	FBal0050199
References ( 21 )

Generate a list of	All references relating to this allele ( 21 )

List References by type	Research paper ( 19 ) Review ( 1 ) Abstract ( 1 )
Recent research papers ( 1 )
	Shen et al., 2011, Science 331(6022): 1333--1336 Function of rhodopsin in temperature discrimination in Drosophila. [FBrf0213227] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\ninaE1

Allele Dmel\ninaE¹