|Feature type||allele||Associated gene||Dmel\ninaE|
|Also Known As||ninaEora, oraJK84, ninaEJK84, ora|
|Map ( GBrowse )|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Gln251 --> stop
|Phenotype Manifest In|
rhabdomere R1 & microvillus
rhabdomere R2 & microvillus
rhabdomere R3 & microvillus
rhabdomere R4 & microvillus
rhabdomere R5 & microvillus
rhabdomere R6 & microvillus
Mutant larvae show defects in discrimination between 18[o]C and 24[o]C in a binary choice thermotaxis assay compared to controls, but discrimination between 18[o]C and cooler or very warm temperatures is normal.
The effect of anoxia as measured in the eye by extracellular voltage change recordings is similar to that of wild type.
The eyelet maintains well-developed rhabdomeres even 1 week after eclosion in mutant flies, although degeneration of ommatidial rhabdomeres R1-R6 is seen.
The whole cell capacitance of photoreceptor cells remains relatively small throughout development, in contrast to wild-type. The magnitude of the rundown current (RDC) is larger than wild-type at all developmental stages. R1 to R6 photoreceptor cells have more microvilli per rhabdomere than wild-type flies and membrane loops at the base of the microvilli are enlarged compared to wild-type.
Third instar foraging larvae show negative photobehaviour indistinguishable from the wild-type response to light. Third instar larvae continue to show negative phototaxis during the wandering stage, in contrast to wild-type larvae.
induced with ort1 as "oraJK84"; ca 10-6 normal RH1 level
|Phenotype Manifest In|
ninaE1 ort1 flies show residual object fixation in tethered flight, but no more than 16% of the residual object fixation is accomplished with wingbeat steering (the predominant steering mechanism of normal flies). ninaE1 ort1 flies are significantly impaired in the ability to maintain their orientation towards a landmark when walking in the Buridan's paradigm assay. Their average and maximum walking speed are reduced to about one-half of the corresponding speed observed under identical conditions in wild-type flies.
|Complementation & Rescue Data|
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 7 )|
|Secondary FlyBase IDs|
|References ( 21 )|
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|Recent research papers ( 1 )|
|Recent reviews (0)|
|All reviews listed in FlyBase were published before 2011|