Allele Dmel\noc^Sco

General Information
Symbol	Dmel\noc^Sco	Species	D. melanogaster
Name		FlyBase ID	FBal0013044
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\noc

Allele class
Mutagen	X ray
Nature of the Allele
Allele class
Mutagen	X ray (Krivshenko, 1959)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference -24.6 to -107.8. From the molecular map of the wild-type noc-Adh region (McGill, Chia, Karp and Ashburner, 1988); coordinate 0 an EcoRI restriction site 1321 bp to the left of the start of transcription of the larval Adh transcript; '+' values to the right, '-' values to the left.
Assay mode
Caused by aberration	Tp(2;2)Sco (Ashburner et al., 1999.10.12, Fuse et al., 1999, Ashburner et al., 1983)
Cytology	Associated with a pair of reciprocal transpositions that are tentatively postulated to result from a pair of inversions, one included within the other. Based on reversion analysis Sco postulated to result from the juxtaposition of noc⁺ and sna⁺ at the 34A5/35D1 junction.
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Krivshenko, 1959) visible \| dominant (Krivshenko, 1959)
Phenotype Manifest In
	chaeta (Davis et al., 1997) head bristle \| dorsal (Gubb et al., 1986) scutellar bristle (Krivshenko, 1959) ocellar bristle (Krivshenko, 1959) humeral bristle (Krivshenko, 1959)
Detailed Description
	Statement Reference antimorph of noc. Phenotype of Sco enhanced by deletion and suppressed by duplication of the noc gene (McGill, Chia, Karp and Ashburner, 1988). Sco/+ flies exhibit the loss of 10-15 bristles, scutellars, notopleurals, upper humerals and anterior postalars being most frequently affected; removes both trichogen and tormogen cell derivatives. Homozygotes nearly lethal; rare homozygous or hemizygous escapers have only eight or so bristles per fly; eyes small and very rough. Escapers short lived and sterile. RK1A. Numerous Sco revertants recovered; some are simple deficiencies (see Df(2L)Sco), whereas others are rearrangements with a deletion for Sco associated with the breakpoint in 35D1-2; revertants without apparent loss of material are given as noc alleles. Breakpoints of the rearrangements indicated are superimposed on the four breakpoints of the original Sco chromosome; the rearrangements have in common a break in 35D1-2 at the proximal end of the Sco rearrangement. Enhanced by noc^TE35B; noc^Sco/noc^TE35B flies have only about 16 dorsal head and thoracic bristles, compared to 25-27 bristles in noc^Sco/+ heterozygotes. (Gubb et al., 1986) Heterozygotes lack all scutellar bristles. One or both postscutellar bristles are sometimes present, but they are shorter and thinner than normal. The ocellar and humeral bristles are often absent. Heterozygotes have good viability and fertility. (Krivshenko, 1959)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference noc^Sco, smi26D¹ has olfaction defective \| male \| dominant phenotype (Anholt et al., 2003) noc^Sco, smi26D¹/smi26D[+] has olfaction defective \| male \| dominant phenotype (Anholt et al., 2003) noc^Sco, smi21F[+]/Pino^smi21F has olfaction defective \| male \| dominant phenotype (Anholt et al., 2003) noc^Sco, Pino^smi21F has olfaction defective \| male \| dominant phenotype (Anholt et al., 2003)
Phenotype Manifest In
Enhanced by
Statement Reference noc^Sco has phenotype, enhanceable by elB^EP2039/Scer\GAL4[-] (Ashburner et al., 1999) noc^Sco has chaeta phenotype, enhanceable by elA¹² (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elA²³ (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elA²⁶ (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elA²⁷ (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elB¹² (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elB²³ (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elB²⁶ (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elB²⁷ (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elB² (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elB³ (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elB⁴ (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elB⁵ (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elB⁶ (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elB⁷ (Davis et al., 1997) noc^Sco has chaeta phenotype, enhanceable by elB⁹ (Davis et al., 1997)
Additional Comments
Genetic Interactions
Statement Reference The noc^Sco bristle phenotype is unaffected by elA¹, elA⁸, elB⁸, elA¹⁰, elB¹⁰, elA¹¹, elB¹¹, elA¹³, elB¹³, elA²¹, elB²¹, elA²², elB²², elA²⁴, elA²⁵, elB²⁵, elA²⁹, elB²⁹, T(Y;2)GT1 and T(2;3)Mpe. (Davis et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 88 )
Bloomington	2555 CyO/noc^Sco 2551 CyO/noc^Sco; TM6/MRS 6226 Df(2L)pr76, noc^Sco/CyO 404 noc^Sco Bl¹/CyO 503 noc^Sco/CyO; eyg¹ 582 noc^Sco/CyO, P{act-lacZ.B}CB1 6311 noc^Sco/CyO, P{sevRas1.V12}FK1 2392 l(2)DTS91¹ noc^Sco/CyO
Kyoto	107400 CyO/noc^Sco 107397 CyO/noc^Sco; TM6/MRS 108687 Df(2L)pr76, noc^Sco/CyO 101837 w¹ ; noc^Sco / CyO
	More stocks available...
Notes on Origin
Discoverer	Krivshenko, 15th Dec. 1956.

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	noc^Sco Sco (Fuse et al., 1999, Ashburner et al., 1999, Davis et al., 1997, Hekmat-Scafe and Carlson, 1996, Krivshenko, 1959, Gubb et al., 1986, )
Name Synonym	Scutoid
Secondary FlyBase IDs

References ( 14 )
Research paper	Anholt et al., 2003, Nature Genetics 35(2): 180--184 The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome. [FBrf0167944] Ashburner et al., 1999, Genetics 153(1): 179--219 An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326] Fuse et al., 1999, Dev. Genes Evol. 209(10): 573--580 Snail-type zinc finger proteins prevent neurogenesis in Scutoid and transgenic animals of Drosophila. [FBrf0111871] Davis et al., 1997, Hereditas 126(1): 67--75 Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Drosophila melanogaster. [FBrf0093413] McGill et al., 1988, Genetics 119: 647--661 The molecular analysis of an antimorphic mutation of Drosophila melanogaster, Scutoid. [FBrf0048235] Gubb et al., 1986, Genetics 112: 551--575 Interactions between white genes carried by a large transposing element and the zeste<up>1</up> allele in Drosophila melanogaster. [FBrf0044464] Ashburner and Harrington, 1984, Chromosoma 89: 329--337 A cytological analysis of the Scutoid mutation of Drosophila melanogaster, and its induced revertants. [FBrf0040522] Ashburner et al., 1983, Genetics 104: 405--431 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0039455] Ashburner et al., 1982, Genetics 102: 401--420 The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for Alcohol dehydrogenase. [FBrf0038047] Krivshenko and Krivshenko, 1960, D. I. S. 34: 55 Linkage data. [FBrf0063595] Krivshenko, 1959, D. I. S. 33: 95--96 [New mutants report.] [FBrf0063601]
Review	Carlson, 1996, Trends Genet. 12(5): 175--180 Olfaction in Drosophila: From odor to behavior. [FBrf0088038] Hekmat-Scafe and Carlson, 1996, Bock, Cardew, 1996: 285--301 Genetic and molecular studies of olfaction in Drosophila. [FBrf0089456]
Personal communication to FlyBase	Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153]

Allele Dmel\nocSco

Allele Dmel\noc^Sco