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General Information
Symbol
Dmel\nod3
Species
D. melanogaster
Name
FlyBase ID
FBal0013067
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
nodb17
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of 0.5kb, from bases 3581 to 4317, and an insertion of 82bp from the unique region 5' of the third repeat. Resulting protein is 34 residues shorter than wild type and 13 amino acids are completely novel.

0.5kb deletion, removing the 3' end of the coding region.

0.5 kb deletion at position +4.2.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Transmission rate of Dp(1;f)J21A through females to progeny is 28%, the nod mutation strongly decreases transmission. Mutation also decreases transmission of Dp(1;f)1B, Dp(1;f)25A and Dp(1;f)10B.

Transmission of Dp(1;f)1187 is reduced from 52% to 3% in homozygous nod3 females and to 47% in nod3/+ females. Severe alleles of nod reduce the transmission of the Dp(1;f)1187 derivative P{PZ}8-23 more than weaker alleles (nodDTW > nodDR3 >= nod3). nod3 increases nondisjunction of Dp(1;f)1187 derivatives Dp(1;f)γ1230 and Dp(1;f)γ878.

High levels of X and fourth chromosome nondisjunction. Hemizygotes exhibit a strong nod phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

nod3 has meiotic cell cycle defective phenotype, enhanceable by neb[+]/nebTE8

nod3 has meiotic cell cycle defective phenotype, enhanceable by neb[+]/nebTE12

nod3 has meiotic cell cycle defective phenotype, enhanceable by neb[+]/nebTE20

Enhancer of
Statement
Reference

nod[+]/nod3 is an enhancer of meiotic cell cycle defective phenotype of nebTE12

nod[+]/nod3 is an enhancer of meiotic cell cycle defective phenotype of nebTE8

nod[+]/nod3 is an enhancer of meiotic cell cycle defective phenotype of nebTE20

Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

nod3 has phenotype, enhanceable by ncd1

Suppressor of
Statement
Reference

nod3 is a suppressor of oocyte & chromatin phenotype of αTub67CP40

Additional Comments
Genetic Interactions
Statement
Reference

Ova from nebTE8/+ (or nebTE12/+ or nebTE20/+) nod2/+ (or nod3/+ or nod4/+) transheterozygous females show a higher rate of 4th chromosome nondisjunction (up to 21%) than females heterozygous for either mutation alone. Transheterozygotes with nebTE2 are sterile.

ncd1 nod3 heterozygous females show an increased level of X and fourth chromosome nondisjunction.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

nod3 is partially rescued by nodhs.Tag:FLAG

Comments

One or two extra copies of nod provided by nodhs.T:Zzzz\FLAG partially rescues transmission of Dp(1;f)J21A and Dp(1;f)10B.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Induced on: In(1)FM7, y31d sc8 wa B vOf.

External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (2)
References (8)