FB2025_01 , released February 20, 2025
Allele: Dmel\norpAP57
Open Close
General Information
Symbol
Dmel\norpAP57
Species
D. melanogaster
Name
FlyBase ID
FBal0013140
Feature type
allele
Associated gene
Dmel\norpA
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Pearn et al., 1996)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G2955A (nucleotide numbering as in FBrf0047660). Amino acid replacement: G768D.

(Pearn et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:4,359,661..4,359,661 [+]
Nucleotide change:

G4359661A

Reported nucleotide change:

G2955A

Amino acid change:

G768D | norpA-PA; G768D | norpA-PB; G768D | norpA-PC; G768D | norpA-PD; G768D | norpA-PE; G768D | norpA-PF

Reported amino acid change:

G768D

(Pearn et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Translocation of trplninaE.T:Avic\GFP-EGFP from the rhabdomere to the cell body is observed upon illumination in norpA47 mutant photoreceptors.

      (Meyer et al., 2006)

      The amplitude of quantum bumps in mutant photoreceptors is smaller than wild type (when ATP is present in the intracellular solution during recordings).

      (Hardie et al., 2002)

      The electroretinogram (ERG) of mutant flies show slow response termination.

      (Cook et al., 2000)

      The electroretinogram (ERG) of norpA47 flies shows reduced amplitude and slower response kinetics compared to that of wild-type flies.

      (Pearn et al., 1996)

      ERG amplitudes approaching that of wild type ERGs when intense stimuli are used.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Pak.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      P57
      (Yoon et al., 2004)
      norpA47
      norpAP57
      (Meyer et al., 2006, Hardie et al., 2002, Cook et al., 2000, Pearn et al., 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)