Allele Dmel\nos¹⁸

General Information
Symbol	Dmel\nos¹⁸	Species	D. melanogaster
Name		FlyBase ID	FBal0013151
Feature type	allele	Associated gene	Dmel\nos
Also Known As	nos^RC

Allele class	amorphic allele - genetic evidence, loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Gavis and Lehmann, 1992) loss of function allele (Curtis et al., 1997, Bhat, 1999)
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The splice donor site of the first intron is disrupted. Nucleotide substitution: G734A. (Curtis et al., 1997)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (Forbes and Lehmann, 1998) female sterile (with Df(3R)Dl-FX1) (Ye et al., 2004) female sterile (with Df(3R)nos) (Li et al., 2009) lethal \| maternal effect \| recessive (Lehmann and Nusslein-Volhard, 1991) neuroanatomy defective \| late third instar larval stage (with Df(3R)Dl-X43) (Brechbiel and Gavis, 2008) neuroanatomy defective \| late third instar larval stage (with nos⁵³) (Brechbiel and Gavis, 2008) neuroanatomy defective \| somatic clone (Ye et al., 2004)
Phenotype Manifest In
	abdomen (Gavis and Lehmann, 1992) class IV dendritic arborizing neuron \| late third instar larval stage (with Df(3R)Dl-X43) (Brechbiel and Gavis, 2008) class IV dendritic arborizing neuron \| late third instar larval stage (with nos⁵³) (Brechbiel and Gavis, 2008) cystoblast & plasma membrane (Bhat, 1999) cystocyte (Styhler et al., 1998) cystocyte & plasma membrane (Bhat, 1999) dendritic arborising neuron & dendrite \| somatic clone (Ye et al., 2004) egg (Mochizuki et al., 2000) egg chamber (Verrotti and Wharton, 2000) egg chamber (with nos⁵³) (Wang and Lin, 2004) female germline stem cell (Bhat, 1999) female germline stem cell & plasma membrane (Bhat, 1999) female germline stem cell \| somatic clone (Gilboa and Lehmann, 2004) fusome (Styhler et al., 1998) germarium (Bhat, 1999) germarium (with Df(3R)Exel6183) (Chau et al., 2012) germarium \| anterior (Styhler et al., 1998) germline cell (Forbes and Lehmann, 1998) germline cyst (with nos⁵³) (Wang and Lin, 2004) germline cyst \| ectopic (with Df(3R)Dl-FX3) (Gilboa and Lehmann, 2004) germline stem cell (with Df(3R)nos) (Li et al., 2009) gonad \| larval stage (with Df(3R)Dl-FX3) (Gilboa and Lehmann, 2004) mitochondrion (Bhat, 1999) ovariole (Bhat, 1999) ovariole (with nos⁵³) (Wang and Lin, 2004) ovary (Verrotti and Wharton, 2000, Styhler et al., 1998) ovary (with Df(3R)nos) (Li et al., 2009) spectrosome (Styhler et al., 1998) telson (Gavis and Lehmann, 1992) testis (Bhat, 1999)
Detailed Description
	Statement Reference The majority of germaria in nos[18]/Df(3R)Exel6183 females produce gametes but become progressively agametic over time. (Chau et al., 2012) Females carrying nos[18]/Df(3R)nos alleles display ovaries that are largely agametic. (Li et al., 2009) From the first larval instar through the early third instar stage, class IV da neurons in nos[18]/Df(3R)Dl-X43 animals show no significant difference in dendrite branching complexity compared to those in control animals. Morphological defects in the class IV da neurons are first detected in nos[18]/Df(3R)Dl-X43 animals at the late third instar stage, when a significant reduction of higher order branching is seen compared to controls (there is a dramatic decrease in the density of terminal dendritic branches). Late third instar nos[18]/nos[53] larvae show a significant reduction in the density of terminal dendritic branches of the class IV da neurons. (Brechbiel and Gavis, 2008) nos¹⁸/+ females have a normal number of germline stem cells per germarium. (Maines et al., 2007) nos¹⁸/Df(3R)Dl-FX3 gonads in larvae at the larval/pupal transition contain many developed cysts. Homozygous germ line stem cell (GSC) clones are rapidly lost from the adult ovary; GSC loss is seen as early as 4 days after clone induction, and by the 6th or 7th day after clone induction, most ovarioles do not contain a mutant GSC. (Gilboa and Lehmann, 2004) Third larval instar class I or class II dendritic arborization neurons which are mutant for nos¹⁸ (generated using the MARCM technique) do not show an alteration in dendrite morphology, as assessed by total length of dendrites and quantitation of dendritic order. Third larval instar class III dendritic arborization neurons which are mutant for nos¹⁸ (generated using the MARCM technique) have significantly elongated dendritic spikes, but the order of dendrites and the length of major dendritic branches is indistinguishable from wild type. Third larval instar class IV dendritic arborization neurons which are mutant for nos¹⁸ (generated using the MARCM technique) show a defect in their dendrites; incomplete coverage of the epidermis is seen in about 20% of the mutant neurons (wild-type neurons cover the epidermis in a complete but non-overlapping fashion), due to a reduction of higher-order branches. (Ye et al., 2004) Homozygous females lay only a few eggs (an average of 6.6 eggs per week compared to 185.0 per week for control females). (Mochizuki et al., 2000) Hemizygous ovaries contain only rare mature egg chambers. (Verrotti and Wharton, 2000) Ovaries of hemizygous females or nos¹⁸/nos⁵³ transheterozygotes contain ovarioles with either no egg chambers or 1-7 egg chambers of different stages. Some of the ovarioles produce only one egg. Ovaries with no developing germ cells occur. Mutant females show three types of egg laying pattern. TypeI (50% hemizygotes): Egg deposition begins on day 2 and stops by day 5. TypeII (41% hemizygotes): Egg deposition begins on day 2 and stops around day 5, to resume after 2 to 12 days. Type III (9% hemizygotes): No eggs are laid (ovarioles devoid of germ cells). Germline defects are age-dependent. Germaria eventually lose stem cells. Plasma membrane degenerates in stem cells and their descendents. The nuclear membrane is unaffected. Germaria from older females contain an abnormally high number of mitochondria. 20% of hemizygous or nos¹⁸/nos⁵³ males show morphologically distinct testis defects: fewer sperm bundles with a large pool of primary spermatocytes filling most of the anterior region of the testis. Number of primary spermatocytes is increased threefold (for hemizygote) compared to wild type. The defective testis generally has fewer coils than wild type. Mutant males can be sorted into three types with respect to ability to inseminate females. TypeIII males are unable to inseminate females throughout a 4 week test period (5% of hemizygous males - testis always have germ cells, either undifferentiated primary spermatocytes, or apparently defective sperm). 90% of males show a Type II defect, 5% show a type 1 defect - all males are sterile by the third week. (Bhat, 1999) The effects of loss of maternal and zygotic nos product on germ cell migration is studied in females with hb¹⁵ nos^BN mutant germ line clones crossed to nos¹⁸/Df(3R)Dl-FX3 males. Germ cells are formed in the embryos indicating nos function is not required for their formation. nos activity is essential for germ cell migration, from stage 10 onwards. Following exit of the germ cells of the posterior midgut pocket, germ cells fail to migrate over the surface of the gut and instead cluster tightly together on the outer gut surface. Mutant germ cells are of varying size and often have an irregular surface. Zygotic nos expression cannot compensate for the loss of maternal nos. The few germ cells that appear to associate with the somatic embryonic gonad are unable to incorporate into the adult gonad even in the presence of a zygotically active copy of the gene. nos¹⁸/Df(3R)Dl-FX3 females lay a small number of eggs early in life but soon become completely sterile. Ovaries from females ranging from 1 to 40 days old are dissected and demonstrate sterility results from loss of germ cells from the ovary. Germline cysts rarely develop into egg chambers after the first few chambers have left the germarium. Putative germ line stem cells are present in the germaria of many mutants ovarioles for at least 10 days following eclosion, these have completely disappeared by 21 days. Transplantation of wild type germ cells can rescue the nos ovary phenotype. The transplanted cells populate the ovary more efficiently in embryos whose endogenous germ cells lack nos activity than in embryos with germ cells containing a zygotically active copy of nos. (Forbes and Lehmann, 1998) Homozygous ovaries contain fewer developing cysts than normal. Many ovarioles consist of a germarium with one to three cysts followed by an extended stalk and one to three normal looking egg chambers. In more extreme cases, only remnants of spectrosome/fusome material can be detected in the anterior of the germarium. (Styhler et al., 1998) Abdominal segmentation phenotype. (Curtis et al., 1995) Homozygous embryos show mirror image duplications of posterior abdominal structures and telson structures. Defect in oogenesis so females only produce small numbers of eggs, presence of the P{nos-bcd3'UTR} construct does not rescue this defect. (Gavis and Lehmann, 1992) maternal-effect lethal. segments, but have normal pole cells and pole plasm; no posterior activity in pole plasm. Transport or diffusion of the nos gene product from the posterior of the embryo seems to be essential for development of the wild-type abdominal pattern. Presence of the nos protein represses the activity of the gene product encoded by the hb maternal transcript in the posterior half of the embryo (Hulskamp, Schroder, Pfeifle, Jackle and Tautz, 1989; Irish, Lehmann and Akam, 1989; Struhl, 1989). Eggs deficient for both hb and nos, when fertilized by hb⁺ sperm, develop into normal embryos and subsequently into viable flies. Mutant embryos lack abdominal
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference nos¹⁸/Df(3R)Dl-FX3 has germline cell \| female \| larval stage phenotype, suppressible \| partially by dpp^Scer\UAS.cSa/Scer\GAL4^{nos.UTR.T:Hsim\VP16} (Gilboa and Lehmann, 2004) nos¹⁸/Df(3R)Dl-FX3 has germline cell \| female \| larval stage phenotype, suppressible \| partially by Scer\GAL4^{nos.UTR.T:Hsim\VP16}/tkv^QD.Scer\UAS (Gilboa and Lehmann, 2004) nos¹⁸/Df(3R)Dl-FX3 has germline cyst \| ectopic phenotype, suppressible \| partially by dpp^Scer\UAS.cSa/Scer\GAL4^{nos.UTR.T:Hsim\VP16} (Gilboa and Lehmann, 2004) nos¹⁸/Df(3R)Dl-FX3 has germline cyst \| ectopic phenotype, suppressible \| partially by Scer\GAL4^{nos.UTR.T:Hsim\VP16}/tkv^QD.Scer\UAS (Gilboa and Lehmann, 2004) nos¹⁸/Df(3R)nos has germline stem cell phenotype, suppressible by bam[+]/bam^BG (Li et al., 2009) nos¹⁸/Df(3R)nos has germline stem cell phenotype, suppressible by bam^EP667/bam[+] (Li et al., 2009) nos¹⁸/Df(3R)nos has germline stem cell phenotype, suppressible by bgcn[+]/bgcn^{bgcnP.T:Avic\GFP} (Li et al., 2009) nos¹⁸/Df(3R)nos has ovary phenotype, suppressible by bam[+]/bam^BG (Li et al., 2009) nos¹⁸/Df(3R)nos has ovary phenotype, suppressible by bam^EP667/bam[+] (Li et al., 2009) nos¹⁸/Df(3R)nos has ovary phenotype, suppressible by bgcn[+]/bgcn^{bgcnP.T:Avic\GFP} (Li et al., 2009) nos¹⁸ has egg chamber phenotype, suppressible \| partially by cup[+]/cup⁸ (Verrotti and Wharton, 2000) nos¹⁸ has egg chamber phenotype, suppressible \| partially by cup²¹/cup[+] (Verrotti and Wharton, 2000) nos¹⁸ has egg phenotype, suppressible \| partially by Hmag\nos1^nos.UTR (Mochizuki et al., 2000) nos¹⁸ has ovary phenotype, suppressible \| partially by cup[+]/cup⁸ (Verrotti and Wharton, 2000) nos¹⁸ has ovary phenotype, suppressible \| partially by cup²¹/cup[+] (Verrotti and Wharton, 2000) nos¹⁸ has phenotype, suppressible by cup¹ (Verrotti and Wharton, 2000) nos¹⁸ has phenotype, suppressible by cup³ (Verrotti and Wharton, 2000) nos¹⁸ has phenotype, suppressible by cup¹³ (Verrotti and Wharton, 2000) nos¹⁸ has phenotype, suppressible by cup¹⁵ (Verrotti and Wharton, 2000) nos¹⁸ has phenotype, suppressible by cup²⁰ (Verrotti and Wharton, 2000) nos¹⁸ has phenotype, suppressible by cup²⁴ (Verrotti and Wharton, 2000) nos¹⁸ has phenotype, suppressible by cup²⁶ (Verrotti and Wharton, 2000)
NOT suppressed by
Statement Reference nos¹⁸ has abdominal segment phenotype, non-suppressible by Hmag\nos1^nos.UTR (Mochizuki et al., 2000)
Suppressor of
Statement Reference nos¹⁸/nos[+] is a suppressor of female germline stem cell \| supernumerary phenotype of Scer\GAL4^{nos.UTR.T:Hsim\VP16}, stwl^EY05697 (Maines et al., 2007)
NOT Suppressor of
Statement Reference nos¹⁸/nos[+] is a non-suppressor of ovary phenotype of cup^unspecified (Verrotti and Wharton, 2000)
Other
Statement Reference cup[+]/cup⁸, nos¹⁸ has embryonic abdominal segment phenotype (Verrotti and Wharton, 2000) cup⁸, nos¹⁸ has embryonic abdominal segment phenotype (Verrotti and Wharton, 2000) cup²¹, nos¹⁸ has embryonic abdominal segment phenotype (Verrotti and Wharton, 2000) cup²¹/cup[+], nos¹⁸ has embryonic abdominal segment phenotype (Verrotti and Wharton, 2000)
Additional Comments
Genetic Interactions
Statement Reference Tumour growth is strongly suppressed in the ovaries of snf[148]/snf[148] ; nos[18]/Df(3R)Exel6183 females. In young animals, 35% of germaria are agametic, In older animals the fraction of agametic germaria increases to 74%, with a marked reduction in tumour size compared with similar aged snf[148]/snf[148] females. The majority of surviving double mutant germ cells have abnormal fusome-like structures and fail to differentiate (indicating that they are more similar to snf than nos mutant germ cells). (Chau et al., 2012) Ovaries of nos[18]/Df(3R)nos females that are also heterozygous for bam[BG] or bam[EP667] produce many egg chambers. Removing one copy of bam increases egg chamber formation at least 10-fold in a nos[18]/Df(3R)nos background. Ovaries of nos[18]/Df(3R)nos females that are also heterozygous for bgcn[bgcnP.T:Avic\GFP] produce many egg chambers. Removing this copy of bgcn increases egg chamber formation in nos[18]/Df(3R)nos mutants. (Li et al., 2009) The phenotype of extra germline stem cells that is seen in the germarium of females expressing stwl^EY05697 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} is suppressed if the females also carry nos¹⁸/+. (Maines et al., 2007) The precocious differentiation of primordial germ cells which is seen in nos¹⁸/Df(3R)Dl-FX3 larval ovaries is partially suppressed by expression of dpp^Scer\UAS.cSa or tkv^QD.Scer\UAS under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}. (Gilboa and Lehmann, 2004) Third larval instar class I dendritic arborization neurons of third instar larvae which are mutant for both pum¹ and nos¹⁸ (generated using the MARCM technique) do not have any defects in dendrite morphology. Third larval instar class III dendritic arborization neurons which are mutant for both pum¹ and nos¹⁸ (generated using the MARCM technique) show an increase in the number of long dendritic spikes to a similar extent as that seen in the single mutant class III dendritic arborization neurons. Third larval instar class IV dendritic arborization neurons which are mutant for both pum¹ and nos¹⁸ (generated using the MARCM technique) show incomplete innervation of the epidermal territory in about 18% of neurons, an extent similar to that seen in the single mutant class IV dendritic arborization neurons. (Ye et al., 2004) The oogenesis defects seen in hemizygous nos¹⁸ females are substantially suppressed by one copy of cup⁸ or cup²¹. Many egg chambers in the rescued ovaries appear normal and mature into oocytes that are fertilised and oviposited (the resulting embryos develop no abdominal segments). The rescued females lay eggs for at least 3 weeks. (Verrotti and Wharton, 2000)
Xenogenetic Interactions
Statement Reference Hmag\nos1^nos.UTR partially rescues the egg laying defects of nos¹⁸ females. Hmag\nos1^nos.UTR fails to rescue the abdominal defects of embryos derived from nos¹⁸ females. (Mochizuki et al., 2000)
Complementation & Rescue Data
Rescued by	nos¹⁸/Df(3R)Dl-X43 is rescued by nos^{3.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is rescued by nos^{108.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is rescued by nos^{295.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is rescued by nos^gnosb (Brechbiel and Gavis, 2008) nos¹⁸ is rescued by nos^+t5.7 (Verrotti and Wharton, 2000) nos¹⁸ is rescued by nos^ΔA (Verrotti and Wharton, 2000) nos¹⁸ is rescued by nos^ΔB (Verrotti and Wharton, 2000) nos¹⁸ is rescued by nos^ΔC (Verrotti and Wharton, 2000) nos¹⁸ is rescued by nos^ΔD (Verrotti and Wharton, 2000) nos¹⁸ is rescued by nos^ΔE (Verrotti and Wharton, 2000) nos¹⁸ is rescued by nos^ΔF (Verrotti and Wharton, 2000) nos¹⁸ is rescued by nos^ΔG (Verrotti and Wharton, 2000) nos⁵³/nos¹⁸ is rescued by nos^{18.T:MS2\MCP.BS} (Brechbiel and Gavis, 2008) nos⁵³/nos¹⁸ is rescued by nos^{+2.18.T:MS2\MCP.BS} (Brechbiel and Gavis, 2008) nos⁵³/nos¹⁸ is rescued by nos^hs.PW (Wang and Lin, 2004) nos^BN/nos¹⁸ is rescued by nos^fl.cCa (Curtis et al., 1997) nos^BN/nos¹⁸ is rescued by nos^Δ218-287 (Curtis et al., 1997)
Partially rescued by	nos¹⁸ is partially rescued by nos^{295.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos^BN/nos¹⁸ is partially rescued by nos^C319Y,C354Y (Curtis et al., 1997) nos^BN/nos¹⁸ is partially rescued by nos^C319Y (Curtis et al., 1997) nos^BN/nos¹⁸ is partially rescued by nos^C354Y (Curtis et al., 1997) nos^BN/nos¹⁸ is partially rescued by nos^Δ50-218 (Curtis et al., 1997) nos^BN/nos¹⁸ is partially rescued by nos^Δ288-314 (Curtis et al., 1997)
Not rescued by	nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{6.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{18.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{19.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{153.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{154.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{165.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{273.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{277.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{505.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{506.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{512.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{516.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{520.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{538.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{549.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{560.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{565.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{579.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{585.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{587.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{599.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{614.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{626.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{627.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸/Df(3R)Dl-X43 is not rescued by nos^{672.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{3.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{6.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{18.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{19.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{108.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{111.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{122.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{139.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{153.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{154.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{165.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{183.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{197.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{204.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{212.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{243.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{246.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{253.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{254.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{258.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{263.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{264.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{272.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{273.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{277.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{286.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{505.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{506.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{512.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{516.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{517.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{520.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{524.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{526.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{538.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{539.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{549.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{554.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{558.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{560.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{565.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{568.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{579.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{581.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{585.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{587.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{592.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{594.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{595.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{599.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{607.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{614.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{620.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{623.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{626.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{627.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{635.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{641.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos¹⁸ is not rescued by nos^{672.αTub84B.UTR.T:Ivir\HA1} (Arrizabalaga and Lehmann, 1999) nos⁵³/nos¹⁸ is not rescued by nos^{+1.18.T:MS2\MCP.BS} (Brechbiel and Gavis, 2008) nos^BN/nos¹⁸ is not rescued by nos^Δ2-287 (Curtis et al., 1997) nos^BN/nos¹⁸ is not rescued by nos^Δ2-301 (Curtis et al., 1997) nos^BN/nos¹⁸ is not rescued by nos^Δ2-314 (Curtis et al., 1997)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Lehmann.

Comments
	Cytoplasm from the posterior pole of D.pseudoobscura.pseudoobscura, D.virilis, D.hydei, M.domestica and C.samoensis embryos is injected into the abdominal region of homozygous early cleavage stage embryos. Injected embryos displayed partial or complete abdominal segmentation, the frequency of strong rescue decreases with increasing evolutionary distance of the donor. (Curtis et al., 1995) Strong allele of nos. Cytoplasmic transplantation of wild type plasm into the abdominal region restores normal abdominal development: surviving adults are fertile. (Lehmann and Nusslein-Volhard, 1991)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	nos¹⁸ (Chau et al., 2012) nos^RC (Zappavigna et al., 2004, Cinnamon et al., 2004, Schaner et al., 2003, Ye et al., 2004, Mochizuki et al., 2000, Verrotti and Wharton, 2000, Arrizabalaga and Lehmann, 1999, Deshpande et al., 1999, Bhat, 1999, Styhler et al., 1998, Forbes and Lehmann, 1998, Curtis et al., 1997, Murata and Wharton, 1995, Curtis et al., 1995, Gavis and Lehmann, 1992, Lehmann and Nusslein-Volhard, 1991, Maines et al., 2007, Brechbiel and Gavis, 2008, Li et al., 2009, Harris et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 26 )

Generate a list of	All references relating to this allele ( 26 )

List References by type	Research paper ( 24 ) Supplementary material ( 1 ) Stock list ( 1 )
Recent research papers ( 2 )
	Chau et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(24): 9465--9470 Sex-lethal enables germline stem cell differentiation by down-regulating Nanos protein levels during Drosophila oogenesis. [FBrf0218549] Harris et al., 2011, Dev. Cell 20(1): 72--83 Brat Promotes Stem Cell Differentiation via Control of a Bistable Switch that Restricts BMP Signaling. [FBrf0212787] Show all research papers ...

Allele Dmel\nos18

Allele Dmel\nos¹⁸