Imaginal discs of homozygous larvae are missing or degenerate. Defects in the cell cycle: few or no dividing cells, affects chromosome condensation and cell division failures that result in highly polyploid cells.
Larvae do not pupate, but can survive for weeks after reaching the size of the mature wild-type larva. Imaginal discs are small and unstructured throughout larval development and the long survival period. A wild-type ring gland implanted into mutant larvae induces puparium formation.
continues development through larval stage, but does not pupariate. Imaginal discs are very small and structureless; ring glands are normal in size on eighth to tenth day of larval life. Puparium formation can be induced by implantation of wild-type ring glands. Discs missing or degenerate; mitotic index of larval ganglion cells reduced; chromosomes swollen and unevenly condensed; few metaphases polyploid; no chromosome fragmentation seen (Gatti and Baker, 1989). Homozygous cells in ovary lethal (Perrimon, Engstrom and Mahowald, 1984). late larval lethal mitotic phenotype: irregular condensation of chromosomes, polyploids