|Feature type||allele||Associated gene||Dmel\Nrg|
|Also Known As||nrg2, Nrg17, l(1)VA142, VA142|
|Allele class||amorphic allele - genetic evidence, hypomorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: W80@.
|Phenotype Manifest In|
dorsal multidendritic neuron ddaE & dendritic tree
dorsal multidendritic neuron ddaE & dendritic tree (with NrgScer\UAS.T:Ivir\HA1), with Scer\GAL4IG1-1
embryonic ganglionic branch & embryonic tracheole
56% of dorsal da neuron E (ddaE) and 14% of ddaD neurons show ectopic branches on their axons at 19-20 hours after egg laying (AEL) in Nrgl7 embryos. In addition, the dendritic arbors of ddaD and ddaE are deformed and this phenotype can be detected at 18-19 hours AEL. Embryos that express NrgScer\UAS.T:Ivir\HA1, under the control of Scer\GAL4IG1-1, in a Nrgl7 background and Scer\GAL4repo show deformed ddaE dendritic arbors.
56% of dorsal da neuron E (ddaE) and 14% of ddaD neurons show ectopic branches on their axons in Nrgl3 embryos. The dendritic branches of ddaD cover a smaller field and have fewer terminals than wild-type ddaD neurons.
Nrg[l10]/Nrg[l7] females are viable at 18[o]C but are inviable at 25[o]C. Nrg/Nrg[l7] and Nrg/Nrg[l7] females show normal sexual receptivity when mated to wild-type males.
In Nrgl7 homozygous embryos, tracheal phenotypes are apparent from stage 15. At stage 16 in these embryos the average dorsal trunk length is significantly greater than wild type (P<0.005) (121+/-2% mean+/-s.e.m., n>5, normalized to stage 16 wild-type value). In addition these embryos have moderately severe diameter increases in the dorsal trunk and other primary tracheal branches, and some ganglionic branches exhibit missing lumen. Unlike wild-type, post stage 15 trachea in Nrgl7 homozygotes are unable to exclude from their lumens, a fluorescently labelled 10kDa dextran injected into the body cavity. This is consistent with these trachea lacking a functioning septate junction barrier.
Homozygous embryos show a general disorganisation of the peripheral nervous system cell bodies. The aCC and SNb motoneurons often show a stalled phenotype, failing to extend normally, and SNb motoneurons sometimes show abnormal contacts with their targets.
|Phenotype Manifest In|
Nrgl7/Nrg[+] is an enhancer of dendrite | larval stage phenotype of NakdsRNA.Scer\UAS, Scer\GAL4elav-C155
Nrgl7/Nrg[+] is an enhancer of dendritic arborizing neuron | larval stage phenotype of NakdsRNA.Scer\UAS, Scer\GAL4elav-C155
Nrg[l7] dominantly enhances the shortening of dendritic length and the reduction in the number of dendritic endpoints of dorsal dendritic arborisation neurons which is seen in larvae expressing Nak[dsRNA.Scer\UAS] under the control of Scer\GAL4[elav-C155].
|Complementation & Rescue Data|
|Fails to complement|
|Partially rescued by|
|Stocks ( 2 )|
|Notes on Origin|
Maternal germline clonal analysis demonstrates there is no maternal effect.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 8 )|
|Secondary FlyBase IDs|
|References ( 13 )|