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General Information
Symbol
Dmel\numb3
Species
D. melanogaster
Name
FlyBase ID
FBal0013188
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
nb3
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

69% of heterozygous flies show rhythmic locomotor activity, with a period of 24.4 +/- 0.1 hours. 79% of numb3/numbSW flies show rhythmic locomotor activity, with a period of 24.6 +/- 0.1 hours.

Homozygous embryos lack many of the dorsal and ventral somatic muscles. The expressivity of the phenotype varies for each muscle and not all muscles are affected. Muscle DA1 is almost always absent, while muscle DO1 is lost from more than 50% of hemisegments. The number of eve-expressing pericardial cells is increased compared to wild-type. The founder cell of the DA1 muscle (FDA1) and its sibling (FDA1sib) both adopt an FDA1sib-like identity. The sibling of the founder cell of the DO1 muscle (FDO1sib) is duplicated at the expense of the founder cell of the DO1 muscle (FDO1). numb3 inscP49 embryos have a qualitatively similar phenotype to numb3 embryos, although they exhibit these phenotypes at higher expressivity.

The RP2sib neuron, vMP2 neuron and U neuron are all duplicated at the expense of their siblings. The number of EL neurons is strongly reduced. pCC/aCC are unaffected. This phenotype is the reciprocal of that shown for spdo, Dl, N and mam embryos.

Clonal analysis revealed an adult mutant macrochaetae phenotype of extra sockets at the expense of hair cells in the notum. Microchaetae in mutant patches show a broader spectrum of transformations, some with a remnant of a hair cell associated with multiple socket-like cells.

apparently null since the neuronal phenotype of homozygotes is indistinguishable from that of hemizygotes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

numb3/+ ; Df(3R)Exel6157/+ double heterozygous embryos show asymmetric cell division defects in "svp" cardiac progenitor cells that are significantly more severe than the additive effects of each of the two single heterozygotes. Defects in the symmetric cell divisions that give rise to the tin-expressing cardial cells in the double heterozygotes are not significantly different from the additive effects of each of the two single heterozygotes.

numb3/+ ; Df(1)CHES-1-like1/+ double heterozygous embryos show asymmetric cell division defects in "svp" cardiac progenitor cells that are significantly more severe than the additive effects of each of the two single heterozygotes. Defects in the symmetric cell divisions that give rise to the tin-expressing cardial cells in the double heterozygotes are not significantly different from the additive effects of each of the two single heterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

On the basis of CNS phenotype numb alleles form a series: numb2 > numb4 > numb1/numb3.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)