Allele Dmel\oc⁹

General Information
Symbol	Dmel\oc⁹	Species	D. melanogaster
Name		FlyBase ID	FBal0013207
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\oc

Allele class	loss of function
Mutagen	ethyl methanesulfonate
Nature of the Allele
Allele class	loss of function (Younossi-Hartenstein et al., 1997)
Mutagen	ethyl methanesulfonate
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Assay mode
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	growth cone (Klambt et al., 1991) anterior commissure (Klambt et al., 1991) posterior commissure (Klambt et al., 1991) midline glial cell (Klambt et al., 1991) abdominal 1 VUM1 neuron (Klambt et al., 1991) abdominal 2 VUM1 neuron (Klambt et al., 1991) abdominal 3 VUM1 neuron (Klambt et al., 1991) abdominal 4 VUM1 neuron (Klambt et al., 1991) abdominal 5 VUM1 neuron (Klambt et al., 1991) abdominal 6 VUM1 neuron (Klambt et al., 1991) abdominal 7 VUM1 neuron (Klambt et al., 1991) abdominal 1 VUM2 neuron (Klambt et al., 1991) abdominal 2 VUM2 neuron (Klambt et al., 1991) abdominal 3 VUM2 neuron (Klambt et al., 1991) abdominal 4 VUM2 neuron (Klambt et al., 1991) abdominal 5 VUM2 neuron (Klambt et al., 1991) abdominal 6 VUM2 neuron (Klambt et al., 1991) abdominal 7 VUM2 neuron (Klambt et al., 1991) abdominal 1 VUM3 neuron (Klambt et al., 1991) abdominal 2 VUM3 neuron (Klambt et al., 1991) abdominal 3 VUM3 neuron (Klambt et al., 1991) abdominal 4 VUM3 neuron (Klambt et al., 1991) abdominal 5 VUM3 neuron (Klambt et al., 1991) abdominal 6 VUM3 neuron (Klambt et al., 1991) abdominal 7 VUM3 neuron (Klambt et al., 1991) neuroblast MNB (Klambt et al., 1991) deutocerebral neuromere (Younossi-Hartenstein et al., 1997) protocerebral neuromere (Younossi-Hartenstein et al., 1997) ventral midline (Menne et al., 1997) abdominal neuromere (Menne et al., 1997)
Detailed Description
	Statement Reference embryonic lethal Structures at the ventral midline and CNS development are defective. Posterior commissure is missing in every segment and anterior commissure formation in the thoracic segments is affected. Growth cones that pioneer the posterior commissure do not make the correct pathway choice and grow anteriorly and posteriorly after correct extension. Growth cones that pioneer the anterior commissure do make the correct pathway choice and grow straight toward the midline. (Klambt et al., 1991) Embryos lack most protocerebral (P) neuroblasts and some deutocerebral (D) neuroblasts. Most of the anterior (Da) and posterior (Dp) deutocerebral neuroblasts, and some of the central (Dc) deutocerebral neuroblasts are missing. Most or all of the protocerebral Pc4, Pa3-6 and Pp cell groups are missing, while Pc1/2 and Pa1/2 neuroblasts are less or not at all affected. The protocerebrum is strongly reduced in size and there are some defects in the deutocerebrum in late embryos. (Younossi-Hartenstein et al., 1997) Many midline neurons are disrupted and mutants exhibit a reduction in the lateral CNS neurones in each abdominal hemineuromere. (Menne et al., 1997)
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments	non-complementing allele
Stocks ( 5 )
Kyoto	107752 w¹ oc⁹/FM7c 108359 Dp(1;Y)850, y⁺/w¹ oc⁹/C(1)DX, y¹ w¹ f¹ 108358 Dp(1;Y)619, y⁺ B^S/w¹ oc⁹/C(1)DX, y¹ w¹ f¹
Bloomington	5679 Dp(1;Y)850, y⁺/w¹ oc⁹/C(1)DX, y¹ f¹ 5678 Dp(1;Y)619, y⁺ B^S/w¹ oc⁹/C(1)DX, y¹ f¹
Notes on Origin
Discoverer

Comments
	Complements: ibx^M72. (Kerr et al., 1997)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	oc⁹ otd^H1 (Menne et al., 1997, Younossi-Hartenstein et al., 1997, Harbecke and Lengyel, 1995, Edgar et al., 1994, Klambt et al., 1991, ) otd^h1 (Rudolph et al., 1997)
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Kerr et al., 1997, J. Neurogenet. 11(3-4): 213--229 Icebox, a recessive X-linked mutation in Drosophila causing low sexual receptivity. [FBrf0128523] Menne et al., 1997, Development 124(24): 4949--4958 CNS midline cells in Drosophila induce the differentiation of lateral neural cells. [FBrf0100162] Rudolph et al., 1997, Development 124(21): 4297--4308 Complex regulatory region mediating tailless expression in early embryonic patterning and brain development. [FBrf0099489] Younossi-Hartenstein et al., 1997, Dev. Biol. 182(2): 270--283 Control of early neurogenesis of the Drosophila brain by the head gap genes tll, otd, ems, and btd. [FBrf0092819] Harbecke and Lengyel, 1995, Roux Arch. dev. Biol. 204(5): 308--329 Genes controlling posterior gut development in the Drosophila embryo. [FBrf0082073] Edgar et al., 1994, Development 120(11): 3131--3143 Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. [FBrf0073015] Grossniklaus et al., 1994, Development 120(11): 3155--3171 Three maternal coordinate systems cooperate in the patterning of the Drosophila head. [FBrf0073235] Klambt et al., 1991, Cell 64: 801--815 The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance. [FBrf0053395] Wieschaus and Noell, 1986, Roux Arch. dev. Biol. 195(1): 63--73 Specificity of embryonic lethal mutations in Drosophila analyzed in germ line clones. [FBrf0045374] Wieschaus et al., 1984, Roux Arch. dev. Biol. 193: 296--307 Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. [FBrf0040178]

Allele Dmel\oc9

Allele Dmel\oc⁹