FB2025_01 , released February 20, 2025
Allele: Dmel\opa1
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General Information
Symbol
Dmel\opa1
Species
D. melanogaster
Name
FlyBase ID
FBal0013265
Feature type
allele
Associated gene
Dmel\opa
Associated Insertion(s)
Carried in Construct
Also Known As
opa5H97, opa5H
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Cimbora and Sakonju, 1995)
Mutagen
ethyl methanesulfonate
(Cimbora and Sakonju, 1995, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Single base change that disrupts the open reading frame and generates a predicted protein lacking the DNA binding domain.

(Cimbora and Sakonju, 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The maxillary lobe is absent in mutant embryos.

      (Rusch and Kaufman, 2000)

      Homozygous embryos have half the number of normal body segments and each is roughly twice the normal width. At embryonic stage 16 none of the three midgut constrictions have formed. At early stages of development interruptions in the visceral mesoderm are observed at many positions along the anterior-posterior axis, as development proceeds interruptions are less frequent. One interruption, coincident with the Antp expression domain, invariably persists.

      (Cimbora and Sakonju, 1995)

      Pair rule phenotype. Only four complete abdominal segments, although occasionally the remnants of a fifth denticle belt are seen.

      (Benedyk et al., 1994)

      Interacts with RpII140wimp maternal effect.

      (Parkhurst and Ish-Horowicz, 1991)

      Double mutants with prd4 seem unsegmented.

      (Tremml and Bienz, 1989)

      Odd numbered denticle bands missing.

      (Jack et al., 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      opa1 is partially rescued by opahs.PB

      (Benedyk et al., 1994)
      Comments

      Mutant phenotype can be partially rescued by opahs.PB exposed to a 20 minute heat shock at cellularization.

      (Benedyk et al., 1994)
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      Comments
      Comments

      prd RNA expression has been studied in opa1 hILK double mutant embryos.

      (Baumgartner and Noll, 1990)

      The expression of l(1)sc is altered during stage 9 in homozygous mutant embryos.

      (Martin-Bermudo et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (20)