Allele Dmel\or^49h

General Information
Symbol	Dmel\or^49h	Species	D. melanogaster
Name		FlyBase ID	FBal0013281
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\or

Allele class
Mutagen	spontaneous
Nature of the Allele
Allele class
Mutagen	spontaneous
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	visible \| recessive eye color defective eye color defective \| somatic clone (Sevrioukov et al., 2005) locomotor behavior defective (Mullins et al., 2000)
Phenotype Manifest In
	photoreceptor cell pigment granule (Mullins et al., 2000) pigment cell pigment cell \| somatic clone (Sevrioukov et al., 2005)
Detailed Description
	Statement Reference Eye colour: bright orange; like or¹. RK1. Examination of mutant eyes reveal a dramatic decrease in the number of electron dense pigment granules seen surrounding groups of photoreceptor cells. Examination of retinula cells from rb¹ mutants reveals normal neuronal anatomy, including normal cytoplasmic synaptic vesicles (SVs). In an assay for larval motility, or^49h mutants performed slightly less well than wild-type larvae. In locomotor assays testing olfactory response to propionic acid, or^49h mutants perform significantly less well than wild-type larvae. (Mullins et al., 2000) Flies with eyes carrying or[49h] clones show a reduction in pigment. (Sevrioukov et al., 2005)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference or^49h has eye color defective \| somatic clone phenotype, non-enhanceable by Vps28^k16503 (Sevrioukov et al., 2005)
Enhancer of
Statement Reference or^49h is an enhancer of visible phenotype of p^p (Falcon-Perez et al., 2007) or^49h is an enhancer of eye color defective phenotype of p^p (Falcon-Perez et al., 2007) or^49h/or[+] is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, bchs^EP2299 (Simonsen et al., 2007)
Phenotype Manifest In
NOT Enhanced by
Statement Reference or^49h has pigment cell \| somatic clone phenotype, non-enhanceable by Vps28^k16503 (Sevrioukov et al., 2005)
Enhancer of
Statement Reference or^49h is an enhancer of pigment cell phenotype of p^p (Falcon-Perez et al., 2007) or^49h/or[+] is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, bchs^EP2299 (Simonsen et al., 2007)
NOT Enhancer of
Statement Reference or^49h is a non-enhancer of ommatidium \| somatic clone phenotype of Vps28^k16503 (Sevrioukov et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference Eye colour: or[49h]; p[p] eyes have significantly reduced levels of red pigment compared to either single mutant. The brown pigment levels are comparable to those seen in p[p] single mutants. (Falcon-Perez et al., 2007) Eyes that carry Vps28[k16503], or[49h] double mutant clones show the same two phenotypes as Vps28[k16503] and or[49h] single mutant clones. (Sevrioukov et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 14 )
Bloomington	2385 or^49h 5390 l(2)37Cc²³ or^49h/CyO 421 noc^Sco Bl¹ or^49h/CyO 5373 Dox-A2³ pr¹ or^49h/CyO 5388 l(2)37Cb¹⁸ pr¹ or^49h/CyO 289 b¹ elA¹ rd^s pr¹ cn¹ or^49h
Kyoto	108200 l(2)37Cc²³ or^49h/CyO 105902 noc^Sco Bl¹ or^49h/CyO 105837 b¹ elA¹ rd^s pr¹ cn¹ or^49h 101393 CyO, Cy¹ dp^lv1 pr¹ cn² / Lim3⁴ or^49h 101352 CyO, Cy¹ dp^lv1 pr¹ cn² / brat^fs1 or^49h 101391 CyO, Cy¹ dp^lv1 pr¹ cn² / l(2)37Bb⁹ or^49h
	More stocks available...
Notes on Origin
Discoverer	Ives, 31st Aug. 1949.

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	or^49h2 (Sevrioukov et al., 2005) or^49h (Falcon-Perez et al., 2007, ) orange^49h (Simonsen et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Falcon-Perez et al., 2007, Traffic 8(2): 154--168 The Drosophila Pigmentation Gene pink (p) Encodes a Homologue of Human Hermansky-Pudlak Syndrome 5 (HPS5). [FBrf0192474] Simonsen et al., 2007, Genetics 176(2): 1283--1297 Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. [FBrf0201586] Sevrioukov et al., 2005, Molec. Biol. Cell 16(5): 2301--2312 A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in Drosophila. [FBrf0188067] Mullins et al., 2000, Molec. gen. Genet. 263(6): 1003--1014 Distinct requirements for the AP-3 adaptor complex in pigment granule and synaptic vesicle biogenesis in Drosophila melanogaster. [FBrf0129983] Ives, 1951, D. I. S. 25: 70 [New mutants report.] [FBrf0063534]

Allele Dmel\or49h

Allele Dmel\or^49h