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General Information
Symbol
Dmel\osa2
Species
D. melanogaster
Name
FlyBase ID
FBal0013299
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

osa2/+ does not affect the position effect variegation at the w locus which is seen in In(1)wm4 flies.

Heterozygous adult males do not show transformation of A6 to A5.

osa2/+ enhances the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5, P{hsp26-pt-T}39C-27 and P{hsp26-pt-T}39C-31. osa2/+ has no effect on the telomeric position effect (TPE) of P{wA}4-4.

osa1/osa2 embryos (lacking zygotic osa function) die late in embryogenesis with no clear defects in segmentation or segment identity. Embryos derived from homozygous female germline clones without paternal rescue (lacking both maternal and zygotic osa function) do not differentiate any cuticle. Embryos derived from homozygous female germline clones with paternal rescue (lacking maternal osa function) secrete cuticle but have severe defects in segmentation, resembling gap gene mutants.

Mutation changes the level of w expression in ph-plac+3 flies; eye colour is lighter.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

osa2 has visible phenotype, enhanceable by corto[+]/corto420

Enhancer of
Statement
Reference

osa2 is an enhancer of visible phenotype of sd1

osa2/osa[+] is an enhancer of visible | dominant phenotype of gcmPyx

osa2, osa[+], brm[+], brm2 is an enhancer of visible | dominant phenotype of gcmPyx

osa2/osa[+] is an enhancer of visible phenotype of corto420

NOT Enhancer of
Statement
Reference

osa2/osa[+] is a non-enhancer of visible phenotype of ct53d

osa2/osa[+] is a non-enhancer of visible phenotype of ctK

osa2/osa[+] is a non-enhancer of visible | homeotic phenotype of Dsp11

Suppressor of
Statement
Reference

osa2 is a suppressor of visible | homeotic phenotype of AntpNs

osa2/osa[+] is a suppressor of visible | dominant | homeotic phenotype of AntpNs

osa2 is a suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

osa2/osa[+] is a suppressor of visible | homeotic phenotype of AntpNs, Pc2

NOT Suppressor of
Statement
Reference

osa2/osa[+] is a non-suppressor of visible phenotype of ctK

osa2/osa[+] is a non-suppressor of visible phenotype of ct53d

osa2 is a non-suppressor of visible phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

osa2 has wing phenotype, enhanceable by Df(2R)ED3921/+

osa2 has adult thorax & macrochaeta phenotype, enhanceable by corto[+]/corto420

Enhancer of
Statement
Reference

osa2 is an enhancer of wing phenotype of sd1

osa2/osa[+] is an enhancer of chaeta | supernumerary phenotype of gcmPyx

osa2, osa[+], brm[+], brm2 is an enhancer of chaeta | supernumerary phenotype of gcmPyx

osa2/osa[+] is an enhancer of wing vein | ectopic phenotype of net1

osa2/osa[+] is an enhancer of adult abdominal segment 4 | ectopic phenotype of E(z)Trm

osa2/osa[+] is an enhancer of adult abdominal segment 5 phenotype of E(z)Trm

osa2/osa[+] is an enhancer of adult mesothoracic segment | ectopic phenotype of E(z)Trm

osa2/osa[+] is an enhancer of adult prothoracic segment phenotype of E(z)Trm

osa2/osa[+] is an enhancer of adult thorax & macrochaeta phenotype of corto420

NOT Enhancer of
Statement
Reference

osa2/osa[+] is a non-enhancer of wing phenotype of ct53d

osa2/osa[+] is a non-enhancer of triple row phenotype of ctK

osa2 is a non-enhancer of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS

Suppressor of
Statement
Reference

osa2/osa[+] is a suppressor | partially of eye phenotype of DrefUAS.cSa, Scer\GAL4GMR.PS

osa2 is a suppressor of antenna phenotype of AntpNs

osa2 is a suppressor of leg | ectopic phenotype of AntpNs

osa2/osa[+] is a suppressor of eye phenotype of Scer\GAL4ey.PH, asf1UAS.cMa

osa2/osa[+] is a suppressor | partially of adult mesothoracic segment | ectopic phenotype of E(z)Trm

osa2/osa[+] is a suppressor | partially of adult metathoracic segment phenotype of E(z)Trm

osa2/osa[+] is a suppressor of eye phenotype of DrefUAS.cSa, Scer\GAL4GMR.PS

osa2/osa[+] is a suppressor of antenna phenotype of AntpNs

osa2/osa[+] is a suppressor of leg | ectopic phenotype of AntpNs

osa2/osa[+] is a suppressor of antenna phenotype of AntpNs, Pc2

osa2 is a suppressor of phenotype of Pc4

NOT Suppressor of
Statement
Reference

osa2/osa[+] is a non-suppressor of triple row phenotype of ctK

osa2/osa[+] is a non-suppressor of wing phenotype of ct53d

osa2 is a non-suppressor of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

One copy of osa2 enhances the scalloped wing phenotype seen in sd1 mutant males.

Flies heterozygous for osa2 show suppression of the Scer\GAL4GMR.PS, DrefScer\UAS.cSa severe rough eye phenotype; eyes are modestly rough and fused ommatidia are not apparent.

γTub23CPl-2 results in a held-out wing phenotype in double heterozygous combination with osa2 (39% penetrance).

The held out wing phenotype is enhanced from 2% penetrance in osa2/+ single mutants to 65% in Df(2R)ED3921/+; osa2/+ flies and 100% in Df(2R)ED3921; osa2/+ flies. The wing vein phenotype of Df(2R)ED3921 single mutants is enhanced by osa2, resulting in loss of L5 up to the posterior crossvein. The osa2 mutation causes an 87% suppression of the AntpNs homeotic transformation.

10+/-2% of KrIf-1/+ flies born to osa2/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers.

osa2/+ suppresses the rough eye phenotype due to Scer\GAL4ey.PH; asf1Scer\UAS.cMa.

An osa2/+ background significantly suppresses the rough eye phenotype found in flies expressing DrefScer\UAS.cSa under the control of Scer\GAL4GMR.PS.

corto420 osa2 double heterozygotes give a higher percentage of thoracic macrochaetae defects than expected for an additive phenotype, indicating a synergistic interaction.

brm2 osa2 double heterozygotes have held-out wings in 97% of cases, a phenotype which is rarely seen in either single heterozygote. Antp73b/+ flies show transformation of antenna to leg. This phenotype is not suppressed by one copy of osa2. AntpNs/+ flies show transformation of antenna to leg. This phenotype is significantly suppressed by one copy of osa2. Expression of Antphs.PHTA during the larval stages results in antenna to leg transformations. This phenotype is not affected if the animals are also carrying osa2.

The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by osa2.

Suppresses the antenna to leg transformation phenotype of Pc2, AntpNs/+. Causes between 50% and 100% suppression of the Pc4/+ extra sex combs phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (37)