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General Information
Symbol
Dmel\ovoD1rv22
Species
D. melanogaster
Name
FlyBase ID
FBal0013399
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
lzlG, ovolzl
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Insertion of a gypsy element.

Insertion components
gypsy{}ovoD1rv22
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The ovaries of ovoD1rv22 females are primarily agametic.

In homozygous mutant germaria, very few egg chambers are found. Those rare egg chambers that are found are small and have no nurse cells.

Ovaries of homozygous females contain germline chambers in less than 20% of cases. Ovaries of ovoD1rv23/ovoD1rv22 females contain germline chambers in less than 20% of cases.

Homozygous female embryos contain the normal number of germ cells. By the end of the third larval instar stage many homozygous female larvae have a reduced number or no germ cells.

XX females have agametic ovaries. ovoD1rv22/Y pseudofemales (carrying traHsp83.PS) have ovaries that contain large numbers of tumorous egg cysts.

Agametic adult ovaries. Many larval ovaries of the agametic heteroallelic combination ovoD1rv23/ovoD1rv22 have near wild type morphology.

The germ cells of XO ovo[-] males have the crystals characteristic of XO males and are fully populated with male germ cells of all stages.

Cold sensitive eye phenotype. ovo-, svb+ phenotype.

Phenotypic category: lzl-.

Germ cell death occurs during early embryogenesis in homozygotes. Adults have rough or glazed eyes (this phenotype is cold-sensitive).

Gene activity is not detectable. Viable. Male germ line is fertile, female germ line has no vitellogenic egg chambers.

At the non-permissive temperature homozygous females lay no eggs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

ovoD1rv22 has ovary phenotype, suppressible by mle1

ovoD1rv22 has ovary phenotype, suppressible by mle9

ovoD1rv22 has ovary phenotype, suppressible by mle14/mle1

NOT suppressed by
Statement
Reference

ovoD1rv22 has ovary phenotype, non-suppressible by SxlM4

ovoD1rv22 has ovary phenotype, non-suppressible by SxlM1

ovoD1rv22 has ovary phenotype, non-suppressible by msl-2138

ovoD1rv22 has ovary phenotype, non-suppressible by msl-2138/msl-21

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

ovoD1rv22 have no adverse effect on the development of the germline in XY traF.Hsp83 pseudofemales; the pseudo-ovaries are filled with a multitude of undifferentiated germ cells.

The ovary phenotype of homozygous ovoD1rv22 females is partially suppressed if they are also carrying mle1/mle1, mle9/mle9 or mle1/mle14. The ovary phenotype is of ovoD1rv23/ovoD1rv22 females partially suppressed if they are also carrying mle1/mle1. The phenotype is not affected if the females are also carrying SxlM4 or SxlM1. The phenotype is not affected if the females are also carrying msl-2138/msl-2138 or msl-2138/msl-21. ovoD1rv23/ovoD1rv22; mle9/mle14 ovaries are phenotypically mosaic, containing germ cells of both male and female morphology. The mosaicism can be at the level of whole ovaries or ovarioles. ovoD1rv22/ovoD1rv22; mle1/mle1 ovaries most often contain germ cells of male morphology rather than female morphology. This phenotype is partially suppressed by SxlM1; ovaries more often contain germ cells of female morphology rather than male morphology.

ovo[-],trahs.PM XY ovaries have abundant germ cells.

The survival of 2X ovoD1rv23/ovoD1rv22 germline cells is enhanced in an mle1/mle5 background. Surviving cells usually form small ovarian tumours. SxlM1 partially rescues the morphology of the otu mutant ovarian tumour cells.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

ovoD1rv22 is partially rescued by ovoOW10.0

Comments

The eye phenotype is partially suppressed by two (but not one) copies of ovoOW10.0.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Revertant.

Comments
Comments

Severe ovo allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (20)