Allele Dmel\ovo^svb-2

General Information
Symbol	Dmel\ovo^svb-2	Species	D. melanogaster
Name		FlyBase ID	FBal0013438
Feature type	allele	Associated gene	Dmel\ovo
Also Known As	svb^YP17b, svb²

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Garfinkel et al., 1992)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| polyphasic (Oliver et al., 1987, Lindsley and Zimm, 1992) lethal \| polyphasic \| recessive (Perrimon et al., 1989)
Phenotype Manifest In
	denticle (Tanaka et al., 2000) denticle \| ectopic (Payre et al., 1999) denticle belt (Payre et al., 1999) embryonic epidermis (Payre et al., 1999)
Detailed Description
	Statement Reference Fails to complement the Dsec\ovo in D.melanogaster/D.sechellia hybrids. (Sucena and Stern, 2000) Mutant embryos develop normally except that they have denticle with reduced number and size (the remaining denticles have a dot-like morphology). (Tanaka et al., 2000) Expression of ovo^Scer\UAS.cPa driven by Scer\GAL4^ptc-559.1 in a ovo^svb-2 background also produces ectopic denticles. Ectopic denticles produced by ubiquitous expression of spi^s.Scer\UAS (driven by Scer\GAL4^e22c or Scer\GAL4^69B) are suppressed in ovo^svb-2 embryos. (Payre et al., 1999) Phenotypic category: ovo⁺ svb^-. (Garfinkel et al., 1992) Phenotypic category: ovo⁺. (Lindsley and Zimm, 1992)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference ovo^svb-2 is a suppressor of denticle \| ectopic phenotype of Scer\GAL4^69B, spi^s.Scer\UAS (Payre et al., 1999) ovo^svb-2 is a suppressor of denticle \| ectopic phenotype of Scer\GAL4^e22c, pan^ΔN.Scer\UAS (Payre et al., 1999) ovo^svb-2 is a suppressor of denticle \| ectopic phenotype of Scer\GAL4^e22c, spi^s.Scer\UAS (Payre et al., 1999) ovo^svb-2 is a suppressor of denticle belt phenotype of wg^l-17 (Payre et al., 1999) ovo^svb-2 is a suppressor of embryonic epidermis phenotype of Scer\GAL4^69B, spi^s.Scer\UAS (Payre et al., 1999) ovo^svb-2 is a suppressor of embryonic epidermis phenotype of Scer\GAL4^e22c, spi^s.Scer\UAS (Payre et al., 1999) ovo^svb-2 is a suppressor of embryonic epidermis phenotype of wg^l-17 (Payre et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference wg^l-17, ovo^svb-2 double mutant embryos produce naked cuticle, with some residual abortive denticles. This phenotype is characteristic of ovo^svb-2 embryos. pan^ΔN.Scer\UAS driven ubiquitously by Scer\GAL4^e22c produces ectopic denticles. Addition of ovo^svb-2 in this background suppresses both normal and pan^ΔN.Scer\UAS induced denticles, producing mostly naked cuticle. (Payre et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Not rescued by	ovo^svb-2 is not rescued by ovo^OW10.0 (Garfinkel et al., 1992)
Comments
Stocks ( 1 )
Bloomington	816 w¹ ovo^svb-2/FM7c
Notes on Origin
Discoverer

Comments
	Maternal germline clonal analysis demonstrates there is no maternal effect. (Perrimon et al., 1989)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	ovo^svb-2 (Popodi et al., 2010-) svb² (Sucena and Stern, 2000, Payre et al., 1999, Galindo et al., 2007, Andrew and Baker, 2008) svb^yp17 (Grinblat et al., 1994) svb^YP17b (Tanaka et al., 2000, Schock et al., 2000, Rulifson et al., 1996, Perrimon et al., 1989, Oliver et al., 1987) svb^YP17B (Garfinkel et al., 1992)
Name Synonym
Secondary FlyBase IDs

References ( 14 )
Research paper	Andrew and Baker, 2008, Dev. Dyn. 237(4): 1198--1206 Expression of the Drosophila secreted cuticle protein 73 (dsc73) requires shavenbaby. [FBrf0204322] Galindo et al., 2007, PLoS Biol. 5(5): e106 Peptides encoded by short ORFs control development and define a new eukaryotic gene family. [FBrf0202317] Schock et al., 2000, Nature 405(6784): 351--354 Phenotypic suppression of empty spiracles is prevented by buttonhead. [FBrf0128636] Sucena and Stern, 2000, Proc. Natl. Acad. Sci. U.S.A. 97(9): 4530--4534 Special feature: divergence of larval morphology between Drosophila sechellia and its sibling species caused by cis-regulatory evolution of ovo/shaven-baby. [FBrf0127340] Tanaka et al., 2000, Europ. J. Biochem. 267(13): 4300--4311 The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. [FBrf0128796] Payre et al., 1999, Nature 400(6741): 271--275 ovo/svb integrates Wingless and DER pathways to control epidermis differentiation. [FBrf0110515] Rulifson et al., 1996, Nature 384(6604): 72--74 wingless refines its own expression domain on the Drosophila wing margin. [FBrf0090775] Grinblat et al., 1994, Development 120(1): 91--102 Functions of the cytoplasmic domain of the beta PS integrin subunit during Drosophila development. [FBrf0068513] Garfinkel et al., 1992, Genetics 130(4): 791--803 Molecular genetics of the Drosophila melanogaster ovo locus, a gene required for sex determination of germline cells. [FBrf0056260] Perrimon et al., 1989, Genetics 121: 333--352 Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. [FBrf0049894] Oliver et al., 1987, Genes Dev. 1: 913--923 The ovo locus is required for sex-specific germ line maintenance in Drosophila. [FBrf0046291] Wieschaus et al., 1984, Rouxs Arch. Dev. Biol. 193: 296--307 Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. [FBrf0040178]
Personal communication to FlyBase	Popodi et al., 2010-, Small X duplications for the stock center collection. Small X duplications for the stock center collection. [FBrf0210621]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Allele Dmel\ovosvb-2

Allele Dmel\ovo^svb-2