Allele Dmel\p¹

General Information
Symbol	Dmel\p¹	Species	D. melanogaster
Name		FlyBase ID	FBal0013443
Feature type	allele	Associated gene	Dmel\p

Allele class
Mutagen	spontaneous
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	spontaneous
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotides 1946-1948 (ATG), part of codons 649-650 of wild-type p are substituted by TT, resulting in a frameshift. The mutated gene encodes residues 1-648 of p, followed by an unrelated segment of 39 amino acids and an early termination codon. (Falcon-Perez et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	chemical sensitive \| recessive (Humphreys et al., 1996) eye color defective (Falcon-Perez et al., 2007, Silva and Mensua, 1985, ) visible (Falcon-Perez et al., 2007) visible \| recessive
Phenotype Manifest In
	pigment cell (Silva and Mensua, 1985, Falcon-Perez et al., 2007)
Detailed Description
	Statement Reference Mutant flies show a significant decrease in ommochrome and drosopterin pigment levels compared to wild type. (Harris et al., 2011) Eye colour: abnormal with reduced levels of red and brown pigment (24 and 24% of wild-type levels respectively). (Falcon-Perez et al., 2007) Homozygous adults are hypersensitive to paraquat. (Humphreys et al., 1996) Eye colour: dull ruby with purplish tone. 40% normal red and 33% normal brown pigment
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement Reference p¹ has eye color defective phenotype, non-suppressible by Scer\GAL4^GMR.PS/prt^Scer\UAS.cFa (Falcon-Perez et al., 2007) p¹ has visible phenotype, non-suppressible by Scer\GAL4^GMR.PS/prt^Scer\UAS.cFa (Falcon-Perez et al., 2007)
Enhancer of
Statement Reference p¹ is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, aos^GD16463 (Harris et al., 2011)
Phenotype Manifest In
NOT suppressed by
Statement Reference p¹ has pigment cell phenotype, non-suppressible by Scer\GAL4^GMR.PS/prt^Scer\UAS.cFa (Falcon-Perez et al., 2007)
Enhancer of
Statement Reference p¹ is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, aos^GD16463 (Harris et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference The reduction in drosopterin pigment levels that is seen in p[1] flies is not affected by HPS4[W515X]. The reduction in drosopterin pigment levels seen in flies carrying w[dsRNA.GMR] is enhanced manyfold if they are also mutant for p[1]. The mispatterning of the eye caused by expression of aos[GD16463] under the control of Scer\GAL4[GMR.PF] is modestly enhanced in a p[1] mutant background. (Harris et al., 2011) Expression of CG10251^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PS does not rescue the eye colour phenotype of p¹ flies. (Falcon-Perez et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	p¹ is rescued by p^Scer\UAS.cFa/Scer\GAL4^GMR.PS (Falcon-Perez et al., 2007)
Comments
Stocks ( 4 )
Bloomington	552 p¹ 2366 Df(3R)XTA1, th¹ st¹ kni^ri-1 rn^roe-1 p¹/Dp(3;3)M95A⁺13, st¹ e¹
Kyoto	105976 p¹ 107287 Df(3R)XTA1, th¹ st¹ kni^ri-1 rn^roe-1 p¹/Dp(3;3)M95A⁺13, st¹ e¹
Notes on Origin
Discoverer	Morgan, July 1910.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	p¹ (Falcon-Perez et al., 2007, Harris et al., 2011) unnamed (Silva and Mensua, 1985)
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Harris et al., 2011, J. Cell Biol. 194(1): 77--87 Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing. [FBrf0214287] Falcon-Perez et al., 2007, Traffic 8(2): 154--168 The Drosophila Pigmentation Gene pink (p) Encodes a Homologue of Human Hermansky-Pudlak Syndrome 5 (HPS5). [FBrf0192474] Humphreys et al., 1996, Genome 39(4): 749--757 Genetic analysis of oxygen defense mechanisms in Drosophila melanogaster and identification of a novel behavioural mutant with a Shaker phenotype. [FBrf0089694] Silva and Mensua, 1985, D. I. S. 61: 156 Synergistic effects between eye-color genes of Drosophila melanogaster. [FBrf0042242] Nolte, 1959, Heredity 13: 233--241 The eye-pigmentary system of Drosophila. [FBrf0012680] Brehme and Demerec, 1942, Growth 6: 351--355 A survey of Malpighian tube color in the eye color mutants of Drosophila melanogaster. [FBrf0005752] Bridges and Morgan, 1923, Publs Carnegie Instn 327: 1--251 The third-chromosome group of mutant characters of Drosophila melanogaster. [FBrf0001261]

Allele Dmel\p1

Allele Dmel\p¹