Open Close
General Information
Symbol
Dmel\pb4
Species
D. melanogaster
Name
FlyBase ID
FBal0013508
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutagen
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C6709698T

Reported nucleotide change:

C1819T

Amino acid change:

Q607term | pb-PA; Q602term | pb-PB; Q602term | pb-PC; Q597term | pb-PD

Reported amino acid change:

Q607term

Comment:

Reported coordinates are with respect to pb-RA and pb-PA.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Coordinates of the lesion are the position in the 2-μ-4a spliced form of pb.

Nucleotide substitution: C1819T.

Amino acid replacement: Q607term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

pb4/pb20 flies show a reduction in length of the maxillary palps, the labellar cap is transformed to an arista and the number of pseudotracheal rows is reduced to 1 or 2.

pb4/pb13 flies have nearly normal labial palps, which show a slight reduction of the pseudotracheal rows. pb4/pb5 flies show a transformation of distal labium to antennal arista.

pb4/pb5 flies have a transformation of the distal labium to antennal arista, with a concomitant reduction of the pseudotrachea.

Flies show transformation of the distal labial palps to antennal aristae. Some pseudotracheal tissue remains on the proximo-medial part of each palp.

Homozygotes show a partial transformation of the labial palps to antennal aristae.

Homozygotes show transformation of the labium to aristal structures. pb4/pb5 flies show mixed transformation of the distal labium to leg and aristal structures.

The labial palp is transformed to antenna.

Hemizygotes have transformations that range from a predominantly antennal morphology to a mixture of antennal-like and leg-like characteristics.

Transformation of the first three pseudotracheal rows of the labial palps to antenna or leg identity.

antenna

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

pb5/pb4 has labial segment phenotype, enhanceable by skdpap-1

pb5/pb4 has pseudotrachea phenotype, enhanceable by skdpap-1

pb5/pb4 has labellum phenotype, enhanceable by Df(3R)ΔC40b

Suppressed by
Statement
Reference

pb4 has labellum phenotype, suppressible by RasGAP1sxt-BJ61

Other
Additional Comments
Genetic Interactions
Statement
Reference

pb4 taraL4/pb13 + flies show a weak but reliable transformation of the distal labium to antennal arista.

The addition of a combination of skdpap-1 and MED17s2956 enhances the transformation phenotype seen in the labium of pb4/pb5 flies. Instead of transformation to antennal structures, a transformation to T1 leg structures (including sex comb teeth and claws) is seen. The addition of skdpap-1 enhances the transformation phenotype seen in the labium of pb4/pb5 flies. Instead of transformation to antennal structures, a transformation to T1 leg structures (including claws) is seen.

The transformation of the labium to aristal structures seen in pb4 homozygotes is altered towards wild-type if the flies also carry one copy of Gap1sxt-BJ61. pb4/pb5 flies also carrying one copy of Df(3R)ΔC40b generally have a more severe labial palp mutant phenotype, including the appearance of prothorax-specific sex comb teeth and distal claws.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Partially rescued by

pb4 is partially rescued by pbRev2.HSPB

pb4 is partially rescued by pbRev19.HSPB

pb4 is partially rescued by pbRev20.HSPB

Comments

The labial palp phenotype is fully rescued by pbhs.PB, is not rescued by pbRev9.HSPB, pbRev14.HSPB, pbRev23.HSPB, pbRev1.HSPB, pbRev5.HSPB, pbRev17.HSPB or pbRev3.HSPB, and is partially rescued by pbRev2.HSPB, pbRev19.HSPB or pbRev20.HSPB.

The labium to antenna phenotype of pb4 flies can be rescued by pbhs.PB.

Images (0)
Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer

Duncan and Kaufman.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (15)