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General Information
Symbol
Dmel\Pc1
Species
D. melanogaster
Name
FlyBase ID
FBal0013551
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
A significant proportion of Pc1 heterozygous adults show a super sex comb phenotype, as compared to controls.
Pc1/+ males display a homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs.
33% of heterozygous males have homeotic transformations of the second and third legs into the first leg (score by the presence of a sex comb on the second and/or third leg).
64% of heterozygous males show transformation of T3 or T2 legs into T1 identity.
Males heterozygous for Pc1 exhibit posterior-to-anterior leg transformation, readily visualized by the ectopic appearance of sex combs on the second or both the second and third legs.
One copy of Pc1 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)wm4. One copy of Pc1 is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.
Heterozygous adults display the following homeotic transformations: sex combs on the second and/or third leg, transformation of the fourth abdominal segment into the semblance of the posterior fifth and defective wing development indicative of wing-to-haltere transformation.
Heterozygous larvae show no significant defects in dendrite morphology of class IV dendrite arborisation (da) neurons. Heterozygous males have ectopic sex combs on the second and third legs.
Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosomes.
Heterozygous adults show transformations of 2nd leg to 1st leg, wing to haltere, and ventral wing margin to dorsal wing margin.
Transformation of anterior segments to the 8th abdominal segment. Double heterozygous adult escapers show a mild homeotic transformation.
Homozygous embryos show variable transformation of the mesothoracic denticle belt and anterior-most dorsal spinules to resemble those of more posterior segments. There is also an anterior transformation of some mesothoracic cuticle structures, such as a reduction in spinule density on the dorsal surface.
partial transformations of second and third legs into first legs in Pc/+ heterozygotes
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Pc1 has homeotic | dominant | male phenotype, enhanceable by CG9007[+]/upSETe00365
Pc1 has homeotic | dominant | male phenotype, enhanceable by upSETMB08950/CG9007[+]
Pc1 has visible phenotype, enhanceable by Hcf[+]/HcfHR1
Pc1 has visible | dominant phenotype, enhanceable by Rm62[+]/Rm6201086
Pc1 has homeotic phenotype, enhanceable by Kdm2KG04325/Kdm2[+]
Pc1 has homeotic phenotype, enhanceable by Kdm2EY01336/Kdm2[+]
Pc1 has homeotic phenotype, enhanceable by Kdm2[+]/Kdm2DG12810
Pc1 has visible | dominant phenotype, enhanceable by wtsx1/wts[+]
Pc1 has visible | homeotic phenotype, enhanceable by bur1/bur[+]
Pc1 has visible | homeotic | female phenotype, enhanceable by Usp7KG06814/Usp7[+]
Pc1 has visible | homeotic phenotype, enhanceable by bur[+]/burk07130
Pc1 has visible | homeotic | female phenotype, enhanceable by Usp7kim1/Usp7[+]
Pc1 has visible | homeotic | male phenotype, enhanceable by Usp7kim1
Suppressed by
Statement
Reference
Pc1 has homeotic phenotype, suppressible | partially by Marcal1[+]/Marcal1del
Pc1, ph-p[+]/ph-p410 has homeotic phenotype, suppressible | partially by Marcal1del/Marcal1del
Enhancer of
Statement
Reference
Pc1/Pc[+] is an enhancer of visible | dominant phenotype of gcmPyx
NOT Enhancer of
Statement
Reference
Pc1/Pc[+] is a non-enhancer of small body | adult stage phenotype of HcfHR1
NOT Suppressor of
Statement
Reference
Pc1/Pc[+] is a non-suppressor of small body | adult stage phenotype of HcfHR1
Pc1 is a non-suppressor of visible phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
Pc1 has sex comb | ectopic phenotype, enhanceable by sxc[+]/sxcH537A
Pc1 has sex comb | ectopic phenotype, enhanceable by sxcH537A
Pc1 has sex comb | ectopic phenotype, enhanceable by pds5e3
Pc1 has sex comb | ectopic | male phenotype, enhanceable by CG9007[+]/upSETe00365
Pc1 has sex comb | ectopic | male phenotype, enhanceable by upSETMB08950/CG9007[+]
Pc1 has mesothoracic leg phenotype, enhanceable by Rm62[+]/Rm6201086
Pc1 has metathoracic leg phenotype, enhanceable by Rm62[+]/Rm6201086
Pc1 has sex comb | ectopic phenotype, enhanceable by Rm62[+]/Rm6201086
Pc1 has sex comb | ectopic phenotype, enhanceable by wtsx1/wts[+]
Pc1 has mesothoracic leg phenotype, enhanceable by wtsx1/wts[+]
Pc1 has metathoracic leg phenotype, enhanceable by wtsx1/wts[+]
Pc1 has sex comb | ectopic | male phenotype, enhanceable by Usp7kim1
Pc1 has wing | male phenotype, enhanceable by Usp7kim1
Pc1 has abdominal segment 4 | male phenotype, enhanceable by bur1/bur[+]
Pc1 has abdominal segment 5 | ectopic | male phenotype, enhanceable by bur1/bur[+]
Pc1 has haltere | ectopic phenotype, enhanceable by bur1/bur[+]
Pc1 has prothoracic leg | ectopic | male phenotype, enhanceable by bur1/bur[+]
Pc1 has sex comb | ectopic | male phenotype, enhanceable by bur1/bur[+]
Pc1 has wing phenotype, enhanceable by bur1/bur[+]
Pc1 has abdominal segment 4 | male phenotype, enhanceable by bur[+]/burk07130
Pc1 has abdominal segment 5 | ectopic | male phenotype, enhanceable by bur[+]/burk07130
Pc1 has haltere | ectopic phenotype, enhanceable by bur[+]/burk07130
Pc1 has prothoracic leg | ectopic | male phenotype, enhanceable by bur[+]/burk07130
Pc1 has sex comb | ectopic | male phenotype, enhanceable by bur[+]/burk07130
Pc1 has wing phenotype, enhanceable by bur[+]/burk07130
Pc1 has haltere | ectopic | female phenotype, enhanceable by Usp7kim1/Usp7[+]
Pc1 has wing | female phenotype, enhanceable by Usp7kim1/Usp7[+]
Pc1 has haltere | ectopic | female phenotype, enhanceable by Usp7KG06814/Usp7[+]
Pc1 has wing | female phenotype, enhanceable by Usp7KG06814/Usp7[+]
Pc1 has haltere | ectopic | male phenotype, enhanceable by Usp7kim1
NOT Enhanced by
Statement
Reference
Pc1 has sex comb | ectopic phenotype, non-enhanceable by pds5e6
Suppressed by
Statement
Reference
Pc1 has sex comb phenotype, suppressible | partially by Marcal1[+]/Marcal1del
Pc1, ph-p[+]/ph-p410 has wing phenotype, suppressible | partially by Marcal1del/Marcal1del
Pc1 has sex comb | ectopic phenotype, suppressible by vtd6
Pc1 has sex comb | ectopic phenotype, suppressible | partially by vtd80Fh-36
Pc1 has sex comb | ectopic phenotype, suppressible by SMC1exc46
Pc1 has sex comb | ectopic phenotype, suppressible by Nipped-B407
Pc1 has sex comb phenotype, suppressible by rdx1
Pc1 has metathoracic leg phenotype, suppressible by rdx1
Pc1 has mesothoracic leg phenotype, suppressible by rdx1
Pc1 has sex comb phenotype, suppressible by rdx2
Pc1 has metathoracic leg phenotype, suppressible by rdx2
Pc1 has mesothoracic leg phenotype, suppressible by rdx2
Pc1 has sex comb phenotype, suppressible by rdx5
Pc1 has metathoracic leg phenotype, suppressible by rdx5
Pc1 has mesothoracic leg phenotype, suppressible by rdx5
Pc1 has sex comb phenotype, suppressible by rdx6
Pc1 has metathoracic leg phenotype, suppressible by rdx6
Pc1 has mesothoracic leg phenotype, suppressible by rdx6
Pc1 has sex comb phenotype, suppressible by ebiWKS-24
Pc1 has metathoracic leg phenotype, suppressible by ebiWKS-24
Pc1 has mesothoracic leg phenotype, suppressible by ebiWKS-24
Pc1 has sex comb phenotype, suppressible by ebiCCS-6
Pc1 has metathoracic leg phenotype, suppressible by ebiCCS-6
Pc1 has mesothoracic leg phenotype, suppressible by ebiCCS-6
Pc1 has sex comb phenotype, suppressible by ebiE90
Pc1 has metathoracic leg phenotype, suppressible by ebiE90
Pc1 has mesothoracic leg phenotype, suppressible by ebiE90
Pc1 has sex comb phenotype, suppressible by ebiE4
Pc1 has metathoracic leg phenotype, suppressible by ebiE4
Pc1 has mesothoracic leg phenotype, suppressible by ebiE4
Pc1 has sex comb | ectopic phenotype, suppressible by polybromo33.2/Bap170[+]/Bap170G5986/polybromo[+]
Pc1 has sex comb | ectopic phenotype, suppressible by e(y)34/Bap170[+]/Bap170G5986
Pc1 has mesothoracic leg phenotype, suppressible by bur[+]/burk07130
Pc1 has mesothoracic leg phenotype, suppressible by bur1/bur[+]
Enhancer of
Statement
Reference
Pc1/Pc[+] is an enhancer of chaeta | supernumerary phenotype of gcmPyx
NOT Enhancer of
Statement
Reference
Pc1/Pc[+] is a non-enhancer of humeral bristle phenotype of HcfHR1
Pc1/Pc[+] is a non-enhancer of sex comb phenotype of HcfHR1
Pc1 is a non-enhancer of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
Suppressor of
Statement
Reference
Pc1/Pc[+] is a suppressor of wing vein | ectopic phenotype of HcfHR1
Pc1/Pc[+] is a suppressor of eye | somatic clone phenotype of Utx1
Pc1 is a suppressor | partially of eye phenotype of CycEJP
Pc1/Pc[+] is a suppressor | partially of adult abdominal segment 4 | ectopic phenotype of E(z)Trm
Pc1/Pc[+] is a suppressor | partially of adult abdominal segment 5 phenotype of E(z)Trm
Pc1/Pc[+] is a suppressor | partially of adult mesothoracic segment | ectopic phenotype of E(z)Trm
Pc1/Pc[+] is a suppressor | partially of adult metathoracic segment phenotype of E(z)Trm
Pc1/Pc[+] is a suppressor of adult prothoracic segment phenotype of E(z)Trm
NOT Suppressor of
Statement
Reference
Pc1/Pc[+] is a non-suppressor of humeral bristle phenotype of HcfHR1
Pc1/Pc[+] is a non-suppressor of sex comb phenotype of HcfHR1
Pc1 is a non-suppressor of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
Pc1 is a non-suppressor of wing phenotype of Scer\GAL4OK386, nejUAS.cMa
Other
Additional Comments
Genetic Interactions
Statement
Reference
The super sex comb phenotype observed in Pc1 heterozygotes is enhanced by sxcH537A heterozygosity, which is further enhanced by sxcH537A homozygosity. sxcH537A/+, Pc1/+ individuals and sxcH537A/sxcH537A, Pc1/+ individuals do not show an ectopic scutellar bristle phenotype, as compared to controls.
The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is exacerbated by combination with a single copy of Pc1. The homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs characteristic for Pc1/+ males is partially suppressed by Marcal1del heterozygosity and to a greater extent (yet still not a full rescue) by Marcal1del homozygosity. Similarly, the partial homeotic wing-to-haltere transformation observed in ph-p410/+;Pc1/+ double heterozygotes is ameliorated by combination with Marcal1del in homozygosity.
The penetrance of the ectopic sex comb phenotype seen on the second and/or third legs of Pc1/+ flies (33%) is enhanced if they are also heterozygous for either upSETe00365 (75%) or upSETMB08950 (75%).
HcfHR1/+ enhances the penetrance of the T2 to T1 transformation (reduction of the sternopleural region) seen in Pc1/+ flies, from 3% to 60%. The adult size and humeral bristle phenotypes of HcfHR1 mutants are not affected by Pc1/+. The reduced sex comb phenotype of HcfHR1 is not modified by Pc1/+. The ectopic vein phenotype of HcfHR1 mutants is suppressed by Pc1/+. 3% of Pc1/+ ; HcfHR1 males have defects in rotation of the genitalia.
Pc1 Ino80Δ4 double heterozygotes have ectopic sex combs on the second and third legs (complete penetrance).
Heterozygosity for Pc1 suppresses the over-representation phenotype of Utx1 mosaics.
95% of Pc1/Rm6201086 double heterozygous males show transformation of T3 or T2 legs into T1 identity.
The frequency of posterior-to-anterior leg transformations is reduced in transheterozygous males when Pc1 is combined with both Bap170G5986/+ and polybromo33.2/+. Hemizygous e(y)34 males display an almost complete suppression of the Pc1 leg transformation phenotype.
The frequency of homeotic transformations is significantly higher in flies transheterozygous for Pc1 and Kdm2KG04325, Kdm2EY01336 or Kdm2DG12810, compared to flies heterozygous for Pc1 alone.
Pc1/Su(z)124 and Pc1/E(z)63 double heterozygous larvae show dendritic defects in class IV dendrite arborisation (da) neurons; there is a significant reduction in the number of dendritic branchpoints. The ectopic sex comb phenotype seen on the second and third legs of Pc1/+ males is enhanced by wtsx1/+.
Usp7KG06814 strongly enhances the frequency and severity of a range of homeotic transformations caused by Pc1flies. In combination with either hetero- (females) or hemizygous (males) Pc1 flies, Usp7KG06814 significantly increases the penetrance of wing-to-haltere transformations. Likewise, there is a strong increase in the frequency and extent of transformations of the fourth abdominal segment (A4) into the semblance of the fifth (A5), indicated by increased dark pigmentation of the A4. Usp7kim1 strongly enhances the frequency and severity of a range of homeotic transformations caused by Pc1 flies. For example, wing-to-haltere transformations occur only very rarely in heterozygous Pc1 flies. However, in combination with either hetero- or hemizygous Usp7kim1, in respectively females or males, the penetrance of wing-to-haltere transformations is significantly increased. Likewise, there is a strong increase in the frequency and extent of transformations of the fourth abdominal segment (A4) into the semblance of the fifth (A5), indicated by increased dark pigmentation of the A4. In males hemizygous for Usp7kim1 and heterozygous for Pc1, the frequency of sex combs on the second leg (L2-L1) is strongly increased compared to flies harboring only the Pc1 mutation. Flies transheterozygous for burk07130 and Pc1 exhibit very strong wing-to-haltere transformations. In addition, males transheterozygous for burk07130 and Pc1 also show partial transformation of the anterior abdominal segments A4 towards A5 and carry sex combs on the second legs. Flies transheterozygous for bur1 and Pc1 exhibit a 2-fold increase in the frequency of L2-L1 transformations, compared to heterozygous Pc1 mutations.
Pc1/Snr1E1 animals have incomplete L2, L4 and L5 wing veins (6%, 38% and 22% respectively) and moderate curling and disruption of the wing along the posterior wing margin.
Mutants heterozygous for lolalk02512, lolalk11212, or lolalk07907, when also heterozygous for Pc1, exhibit a contrabithorax phenotype, which is a wing-to-haltere transformation due to ectopic expression of Ubx in the posterior part of the wing disc. This phenotype is further enhanced in specific lolal heteroallelic viable combinations, such as lolalk02512/lolal311a, lolalk11212/lolal311a, and lolalk07907/lolal311a, when also heterozygous for Pc1.
The addition of lolalk02512/+ to heterozygous Pc1 animals produces crumbled wings with defective margin.
Mutant weakly suppresses the CycEJP rough eye phenotype.
Pc1 suppresses the pairing-dependent silencing of wenh.iab-7PRE.410 seen in flies homozygous for P{iab-7PRE-wenh.410}2 but not in flies homozygous for P{iab-7PRE-wenh.410}1. Pc1 suppresses the pairing-dependent silencing of wenh.iab-7PRE.260 seen in flies homozygous for P{iab-7PRE-wenh.260}1 or P{iab-7PRE-wenh.260}2.
Has little or no effect on the phenotype of E2fGMR.PD DpGMR.PD BacA\p35GMR.PH flies.
Xenogenetic Interactions
Statement
Reference
The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is exacerbated by combination with a single copy of Pc1.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (5)
Notes on Origin
Discoverer
P.H. Lewis.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (53)