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General Information
Symbol
Dmel\Pc2
Species
D. melanogaster
Name
FlyBase ID
FBal0013552
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Heterozygous adults show transformations of 2nd leg to 1st leg, wing to haltere, and ventral wing margin to dorsal wing margin. Pc22/Pc2 transheterozygotes survive to the pupal stage, giving pharate adults with a strong Pc adult phenotype: there are intersegmental, wing to haltere, extra sex comb and abdominal homeotic transformations. In addition, there is partial transformation of ventral wing margin to dorsal, and posterior wing to anterior.
Transformation of anterior segments to the 8th abdominal segment. Double heterozygous adult escapers show a mild homeotic transformation.
Homozygous escunspecified embryos (derived from homozygous escunspecified mothers) that are also homozygous for Pc2 show a more extreme transformation than those carrying two copies of Pc+.
partial transformations of second and third legs into first legs in Pc/+ heterozygotes
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
AntpNs, Pc2 has visible | homeotic phenotype, enhanceable by Pcl[+]/Pcl18
Suppressed by
Statement
Reference
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by brm1/brm[+]
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by osa[+]/osa3
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by osa[+]/osa4
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by trxE3/trx[+]
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by mor[+]/mor1
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by mor2/mor[+]
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by osa1/osa[+]
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by osa2/osa[+]
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
AntpNs, Pc2 has antenna phenotype, enhanceable by Pcl[+]/Pcl18
Suppressed by
Statement
Reference
AntpNs, Pc2 has antenna phenotype, suppressible by osa2/osa[+]
AntpNs, Pc2 has antenna phenotype, suppressible by osa[+]/osa3
AntpNs, Pc2 has antenna phenotype, suppressible by osa[+]/osa4
AntpNs, Pc2 has antenna phenotype, suppressible by trxE3/trx[+]
AntpScx, Pc2 has sex comb phenotype, suppressible by trxE3/trx[+]
AntpNs, Pc2 has antenna phenotype, suppressible by brm1/brm[+]
AntpNs, Pc2 has antenna phenotype, suppressible by mor[+]/mor1
AntpNs, Pc2 has antenna phenotype, suppressible by mor2/mor[+]
AntpNs, Pc2 has antenna phenotype, suppressible by osa1/osa[+]
NOT Enhancer of
Statement
Reference
Pc2 is a non-enhancer of eye phenotype of CycEJP
NOT Suppressor of
Statement
Reference
Pc2 is a non-suppressor of eye phenotype of CycEJP
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
The addition of heterozygous Pc2 has no effect on the Pairing sensitive silencing effect seen in wMcp.10, and wMcp.scs'.11. The addition of heterozygous Pc2 has no effect on the Pairing sensitive silencing effect seen in wMcp.scs'.11 (P{Mcp-w#11}16/+, P{Mcp-w#11}102/+) double heterozygous insertions. The addition of heterozygous Pc2 has no effect on the Pairing sensitive silencing effect seen in wMcp.scs'.14/wMcp.13 (P{Mcp-w#14}AP-2stummelbein/+, P{Mcp-w#13}116/+) double heterozygous insertions.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Not rescued by
Pc2 is not rescued by PcEGFP
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
Puro, Oct. 1961.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Pc2
Name Synonyms
Secondary FlyBase IDs
    References (17)