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General Information
Symbol
Dmel\Pc4
Species
D. melanogaster
Name
FlyBase ID
FBal0013554
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
PcR1
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Pc4 embryos from hetrozygous mothers show segregation defects in anaphase and telophase as judged by the presence of chromatin bridges. Most of these chromatin bridges are probably resolved because large irregularly-shaped nuclei and polyploid nuclei are only seen at a low penetrance. Pc4 embryos also show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. Fallout nuclei tend to be observed in pairs or clusters and have a late telophase appearance. There is no evidence of metaphase defects in these embryos.

Pc4 males have ectopic sex combs on the second and third leg.

93% of heterozygous males have sex comb teeth on the second and/or third leg. Expressivity of the phenotype is 14%.

Pc4/+ heterozygotes exhibit a wild-type number of sex combs, with 2 legs exhibiting sex combs.

Pc4/Df(3R)ry27 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 2.7 legs with sex combs, compared to 2.1 in Pc4/+ heterozygotes.

Pc4/Df(3R)ry619 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 2.9 legs with sex combs, compared to 2.3 in Pc4/Tp(3;3)MRS heterozygotes.

Heterozygous males have ectopic sex combs on the second and third legs.

An average of about 1 ectopic sex comb teeth are seen per leg in Pc4 mutant animals.

Approximately 57% of heterozygous males have ectopic sex combs on the second and/or third legs, indicating a transformation towards first leg.

The extra sex combs phenotype of Pc4 is dominantly enhanced by E(Pc)1 and E(Pc)2. The extra sex combs phenotype is also very weakly enhanced by E(Pc)rv4, E(Pc)rv9 and E(Pc)rv10.

Heterozygous adults have sex comb teeth on the second and third legs. The penetrance of this phenotype is 100% and the expressivity is 25%.

Mutation has no effect on the hhMrt wing phenotype.

Partial transformation of T2 and T3 legs toward T1.

Embryonic lethal or semi-lethal when heterozygous with ph-d2. Unhatched larvae carry segmentation defects or polarity defects.

Heterozygous adults show transformations of 3rd and 2nd leg to 1st leg, wing to haltere, and ventral wing margin to dorsal wing margin.

Haplo-abnormal phenotype is suppressed by a duplication carrying Pc.

partial transformations of second and third legs into first legs in Pc/+ heterozygotes

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Pc4 has visible | dominant phenotype, enhanceable by psq[+]/psq0115

Pc4 has visible | dominant phenotype, enhanceable by psq[+]/psq02403

Pc4 has visible | dominant phenotype, enhanceable by psq8109/psq[+]

Pc4 has visible | dominant phenotype, enhanceable by psqΔ18/psq[+]

Pc4 has visible | dominant phenotype, enhanceable by psq[+]/psqF112

Pc4 has visible | dominant phenotype, enhanceable by psq[+]/psqE34

Pc4 has visible | dominant phenotype, enhanceable by psqE39/psq[+]

Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-2K1/Mi-2[+]

Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-21/Mi-2[+]

Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-2[+]/Mi-2j3D4

Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-24/Mi-2[+]

Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-25/Mi-2[+]

Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-2[+]/Mi-26

Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-27/Mi-2[+]

Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-28/Mi-2[+]

Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-29/Mi-2[+]

Pc4 has visible | dominant | homeotic phenotype, enhanceable by Pcl10/Pcl[+]

Pc4 has visible | dominant phenotype, enhanceable by E(Pc)1

Pc4 has visible | dominant phenotype, enhanceable by E(Pc)2

Pc4 has visible | dominant phenotype, enhanceable by E(Pc)rv4

Pc4 has visible | dominant phenotype, enhanceable by E(Pc)rv9

Pc4 has visible | dominant phenotype, enhanceable by E(Pc)rv10

Suppressed by
Statement
Reference

Pc4 has visible | dominant phenotype, suppressible | partially by tna1

Pc4 has visible phenotype, suppressible by vtd10

Pc4 has visible phenotype, suppressible by vtd3

Pc4 has visible phenotype, suppressible by vtd4

Pc4 has visible phenotype, suppressible by vtd7

Pc4 has visible phenotype, suppressible by vtd8

Pc4 has visible phenotype, suppressible by vtd9

Pc4 has visible phenotype, suppressible by vtd2

Pc4 has visible phenotype, suppressible by l(3)80Fj2-30

Pc4 has visible | dominant | homeotic phenotype, suppressible by lawcp1

Pc4 has visible | dominant | homeotic phenotype, suppressible by mor2

Pc4 has visible | dominant | adult stage phenotype, suppressible by mor2

Pc4 has visible | dominant | homeotic phenotype, suppressible by mor4

Pc4 has visible | dominant | adult stage phenotype, suppressible by mor4

Pc4 has visible | dominant | homeotic phenotype, suppressible by mor1

Pc4 has visible | dominant | adult stage phenotype, suppressible by mor1

NOT suppressed by
Statement
Reference

Pc4 has visible phenotype, non-suppressible by vtd11

Pc4 has visible phenotype, non-suppressible by vtd12

NOT Suppressor of
Statement
Reference

Pc4 is a non-suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

Phenotype Manifest In
Enhanced by
Statement
Reference

Pc4 has sex comb phenotype, enhanceable by Hsc70-4195/Hsc70-4[+]

Pc4 has leg phenotype, enhanceable by psq[+]/psq0115

Pc4 has sex comb | ectopic phenotype, enhanceable by psq[+]/psq0115

Pc4 has leg phenotype, enhanceable by psq[+]/psq02403

Pc4 has sex comb | ectopic phenotype, enhanceable by psq[+]/psq02403

Pc4 has leg phenotype, enhanceable by psq8109/psq[+]

Pc4 has sex comb | ectopic phenotype, enhanceable by psq8109/psq[+]

Pc4 has leg phenotype, enhanceable by psqΔ18/psq[+]

Pc4 has sex comb | ectopic phenotype, enhanceable by psqΔ18/psq[+]

Pc4 has leg phenotype, enhanceable by psq[+]/psqF112

Pc4 has sex comb | ectopic phenotype, enhanceable by psq[+]/psqF112

Pc4 has leg phenotype, enhanceable by psq[+]/psqE34

Pc4 has sex comb | ectopic phenotype, enhanceable by psq[+]/psqE34

Pc4 has leg phenotype, enhanceable by psqE39/psq[+]

Pc4 has sex comb | ectopic phenotype, enhanceable by psqE39/psq[+]

Pc4 has sex comb phenotype, enhanceable by HDAC104556

Pc4 has sex comb phenotype, enhanceable by HDAC1303

Pc4 has sex comb phenotype, enhanceable by HDAC1313

Pc4 has sex comb phenotype, enhanceable by HDAC1def8

Pc4 has sex comb phenotype, enhanceable by Df(3L)10H

Pc4 has sex comb phenotype, enhanceable by Asx3

Pc4 has sex comb phenotype, enhanceable by Asx8

Pc4 has sex comb phenotype, enhanceable by Asx9

Pc4 has abdominal segment phenotype, enhanceable by AsxP1

Pc4 has sex comb phenotype, enhanceable by AsxP1

Pc4 has phenotype, enhanceable by Df(2R)trix/+

Pc4 has sex comb phenotype, enhanceable by Asx13

Pc4 has sex comb phenotype, enhanceable by Asx1

Pc4 has abdominal segment phenotype, enhanceable by Asx3

Pc4 has mesothoracic leg phenotype, enhanceable by Mi-2K1/Mi-2[+]

Pc4 has metathoracic leg phenotype, enhanceable by Mi-2K1/Mi-2[+]

Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-2K1/Mi-2[+]

Pc4 has mesothoracic leg phenotype, enhanceable by Mi-21/Mi-2[+]

Pc4 has metathoracic leg phenotype, enhanceable by Mi-21/Mi-2[+]

Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-21/Mi-2[+]

Pc4 has mesothoracic leg phenotype, enhanceable by Mi-2[+]/Mi-2j3D4

Pc4 has metathoracic leg phenotype, enhanceable by Mi-2[+]/Mi-2j3D4

Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-2[+]/Mi-2j3D4

Pc4 has mesothoracic leg phenotype, enhanceable by Mi-24/Mi-2[+]

Pc4 has metathoracic leg phenotype, enhanceable by Mi-24/Mi-2[+]

Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-24/Mi-2[+]

Pc4 has mesothoracic leg phenotype, enhanceable by Mi-25/Mi-2[+]

Pc4 has metathoracic leg phenotype, enhanceable by Mi-25/Mi-2[+]

Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-25/Mi-2[+]

Pc4 has mesothoracic leg phenotype, enhanceable by Mi-2[+]/Mi-26

Pc4 has metathoracic leg phenotype, enhanceable by Mi-2[+]/Mi-26

Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-2[+]/Mi-26

Pc4 has mesothoracic leg phenotype, enhanceable by Mi-27/Mi-2[+]

Pc4 has metathoracic leg phenotype, enhanceable by Mi-27/Mi-2[+]

Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-27/Mi-2[+]

Pc4 has mesothoracic leg phenotype, enhanceable by Mi-28/Mi-2[+]

Pc4 has metathoracic leg phenotype, enhanceable by Mi-28/Mi-2[+]

Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-28/Mi-2[+]

Pc4 has mesothoracic leg phenotype, enhanceable by Mi-29/Mi-2[+]

Pc4 has metathoracic leg phenotype, enhanceable by Mi-29/Mi-2[+]

Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-29/Mi-2[+]

Pc4 has mesothoracic leg phenotype, enhanceable by Pcl10/Pcl[+]

Pc4 has metathoracic leg phenotype, enhanceable by Pcl10/Pcl[+]

Pc4 has sex comb | ectopic phenotype, enhanceable by Pcl10/Pcl[+]

Pc4 has leg phenotype, enhanceable by E(Pc)1

Pc4 has leg phenotype, enhanceable by E(Pc)2

Pc4 has leg phenotype, enhanceable by E(Pc)rv4

Pc4 has leg phenotype, enhanceable by E(Pc)rv9

Pc4 has leg phenotype, enhanceable by E(Pc)rv10

Pc4 has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)1

Pc4 has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)2

Pc4 has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)rv4

Pc4 has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)rv9

Pc4 has sex comb | ectopic phenotype, enhanceable by E(Pc)rv10/E(Pc)[+]

Pc4 has phenotype, enhanceable by Pcl18

NOT Enhanced by
Statement
Reference

Pc4 has sex comb | supernumerary phenotype, non-enhanceable by Spps1/Spps1

Pc4 has mesothoracic leg phenotype, non-enhanceable by Deaf1S10B

Pc4 has sex comb | ectopic phenotype, non-enhanceable by Deaf1S10B

Pc4 has mesothoracic leg phenotype, non-enhanceable by Deaf1k3

Pc4 has sex comb | ectopic phenotype, non-enhanceable by Deaf1k3

Suppressed by
Statement
Reference

Pc4 has sex comb phenotype, suppressible by vtdex3

Pc4 has sex comb phenotype, suppressible by vtd4

Pc4 has phenotype, suppressible | partially by Nipped-B29/Nipped-B[+]

Pc4 has mesothoracic leg phenotype, suppressible | partially by tna1

Pc4 has metathoracic leg phenotype, suppressible | partially by tna1

Pc4 has sex comb | ectopic phenotype, suppressible | partially by tna1

Pc4 has sex comb phenotype, suppressible by HDAC1326

Pc4 has sex comb | ectopic phenotype, suppressible by l(3)80Fj2-30

Pc4 has sex comb | ectopic phenotype, suppressible by vtd10

Pc4 has sex comb | ectopic phenotype, suppressible by vtd3

Pc4 has sex comb | ectopic phenotype, suppressible by vtd4

Pc4 has sex comb | ectopic phenotype, suppressible by vtd7

Pc4 has sex comb | ectopic phenotype, suppressible by vtd8

Pc4 has sex comb | ectopic phenotype, suppressible by vtd9

Pc4 has sex comb | ectopic phenotype, suppressible by vtd2

Pc4 has prothoracic leg phenotype, suppressible by lawcp1

Pc4 has mesothoracic leg phenotype, suppressible by lawcp1

Pc4 has metathoracic leg phenotype, suppressible by mor1

Pc4 has sex comb phenotype, suppressible by mor1

Pc4 has mesothoracic leg phenotype, suppressible by mor2

Pc4 has metathoracic leg phenotype, suppressible by mor2

Pc4 has sex comb phenotype, suppressible by mor2

Pc4 has mesothoracic leg phenotype, suppressible by mor4

Pc4 has metathoracic leg phenotype, suppressible by mor4

Pc4 has sex comb phenotype, suppressible by mor4

Pc4 has mesothoracic leg phenotype, suppressible by mor1

Pc4 has phenotype, suppressible by vtd3

Pc4 has phenotype, suppressible by vtd4

Pc4 has phenotype, suppressible by vtd2

Pc4 has phenotype, suppressible by Dll12

Pc4 has phenotype, suppressible by ScrE1

Pc4 has phenotype, suppressible by ScrE2

Pc4 has phenotype, suppressible by ScrE3

Pc4 has phenotype, suppressible by ScrE4

Pc4 has phenotype, suppressible by Su(Pc)37D1

Pc4 has phenotype, suppressible by Vha5515

Pc4 has phenotype, suppressible by Vha5516

Pc4 has phenotype, suppressible by brm2

Pc4 has phenotype, suppressible by brm3

Pc4 has phenotype, suppressible by brm4

Pc4 has phenotype, suppressible by brm5

Pc4 has phenotype, suppressible by brm6

Pc4 has phenotype, suppressible by btldev1

Pc4 has phenotype, suppressible by btldev2

Pc4 has phenotype, suppressible by kis1

Pc4 has phenotype, suppressible by kis2

Pc4 has phenotype, suppressible by kis3

Pc4 has phenotype, suppressible by kis4

Pc4 has phenotype, suppressible by kis5

Pc4 has phenotype, suppressible by kis6

Pc4 has phenotype, suppressible by kis7

Pc4 has phenotype, suppressible by kis8

Pc4 has phenotype, suppressible by kis9

Pc4 has phenotype, suppressible by kto1

Pc4 has phenotype, suppressible by mor3

Pc4 has phenotype, suppressible by mor4

Pc4 has phenotype, suppressible by mor5

Pc4 has phenotype, suppressible by mor6

Pc4 has phenotype, suppressible by osa1

Pc4 has phenotype, suppressible by osa2

Pc4 has phenotype, suppressible by osa3

Pc4 has phenotype, suppressible by osa4

Pc4 has phenotype, suppressible by skd1

Pc4 has phenotype, suppressible by skd2

Pc4 has phenotype, suppressible by sls1

Pc4 has phenotype, suppressible by trxB14

Pc4 has phenotype, suppressible by trxE10

Pc4 has phenotype, suppressible by trxE11

Pc4 has phenotype, suppressible by trxE13

Pc4 has phenotype, suppressible by trxE1

Pc4 has phenotype, suppressible by trxE2

Pc4 has phenotype, suppressible by trxE4

Pc4 has phenotype, suppressible by trxE5

Pc4 has phenotype, suppressible by trxE6

Pc4 has phenotype, suppressible by trxE7

Pc4 has phenotype, suppressible by trxE8

Pc4 has phenotype, suppressible by trxE9

Pc4 has phenotype, suppressible by urd1

Pc4 has phenotype, suppressible by Nsf2urd-2

Pc4 has phenotype, suppressible by vtd1

Pc4 has phenotype, suppressible by vtd5

NOT suppressed by
Statement
Reference

Pc4 has mesothoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

Pc4 has metathoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

Pc4 has mesothoracic leg phenotype, non-suppressible by Deaf1S10B

Pc4 has sex comb | ectopic phenotype, non-suppressible by Deaf1S10B

Pc4 has mesothoracic leg phenotype, non-suppressible by Deaf1k3

Pc4 has sex comb | ectopic phenotype, non-suppressible by Deaf1k3

Pc4 has sex comb | ectopic phenotype, non-suppressible by vtd11

Pc4 has sex comb | ectopic phenotype, non-suppressible by vtd12

Pc4 has phenotype, non-suppressible by lawc+10

Enhancer of
Statement
Reference

Pc4 is an enhancer of wing vein L3 phenotype of rhove-1

NOT Enhancer of
Statement
Reference

Pc4 is a non-enhancer of sex comb phenotype of Scr2

Suppressor of
Statement
Reference

Pc4 is a suppressor | partially of eye phenotype of CycEJP

NOT Suppressor of
Statement
Reference

Pc4 is a non-suppressor of sex comb phenotype of Scr2

Other
Additional Comments
Genetic Interactions
Statement
Reference

Df(2R)ED3921 fails to suppress the ectopic sex comb phenotype of Pc4 mutants.

Pc4/Snr1E1 animals have incomplete L3, L4 and L5 wing veins (9%, 42% and 37% respectively) and moderate curling and disruption of the wing along the posterior wing margin. Pc4/brm2 animals have an incomplete L3 wing vein (15%).

Pc4/Hsc70-4195 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 2.4 legs with sex combs, compared to 2.0 in wild-type.

Mutant weakly suppresses the CycEJP rough eye phenotype.

The ectopic sex comb phenotype seen on the second and third legs of Pc4/+ males is dominantly enhanced by psq0115, psq02403, psq8109, psqΔ18, psqF112, psqE34 or psqE39.

The average number of sex comb teeth per first leg Scr2/+ males is not affected if they are also carrying Pc4. The average number of sex comb teeth per first leg Df(3R)Scr/+ males is not affected if they are also carrying Pc4.

Deaf1k3 or Deaf1S10B do not change the number of ectopic sex combs in the T2 legs of Pc4 males.

The addition of Df(3L)10H, Rpd304556, Rpd3303, Rpd3313 or Rpd3def8 to Pc4 animals more than doubles the average number of ectopic sex comb teeth seen per leg. The addition of Rpd3326 to Pc4 animals partially suppresses the ectopic sex comb teeth phenotype.

AsxP1 strongly enhances the extra sex combs phenotype and abdominal homeotic transformations associated with Pc4. Pc4/+, Df(2R)trix/+ show a darkly pigmented outgrowth from the first thoracic segment, corresponding to a strong posterior transformation of the prothorax to mesothorax.

The leg transformation phenotype of Pc4/+ males is largely suppressed by lawcp1.

The formation of extra sex combs on the second and third legs in Pc4/+ flies is dominantly enhanced by Mi-2K1, Mi-21, Mi-2j3D4, Mi-24, Mi-25, Mi-26, Mi-27, Mi-28, Mi-29 or Pcl10. The formation of extra sex combs on the second and third legs in Pc4/+ flies is not enhanced by Trl62, Trl3 or Trls2325.

The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is not suppressed by Pc4.

The penetrance and expressivity of the Pc4/+ transformation phenotype is dominantly suppressed by mor1, mor2 or mor4.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Russell.

Comments
Comments

The penetrance for the Scr derepression phenotype in Pc4 heterozygotes is 100%.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (42)