A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\Pc4

General Information
SymbolDmel\Pc4SpeciesD. melanogaster
NameFlyBase IDFBal0013554
Feature typealleleAssociated geneDmel\Pc
Also Known AsPcR1
Allele classloss of function allele
Mutagengamma ray
hide Recent Updates
Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Update Feed
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
atom feed
FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
loss of function allele
(Cheng et al., 1994)
Mutagen
gamma ray
(Tiong and Russell, 1990)
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
 
 
Cytology
hide Phenotypic Data
hide Phenotypic Class
lethal | embryonic stage | recessive
(Tiong and Russell, 1990)
mitotic cell cycle defective | embryonic stage
(O'Dor et al., 2006)
visible
(Schulze et al., 2001)
visible | adult stage | dominant
(Brizuela and Kennison, 1997)
visible | dominant
(Gutierrez et al., 2003, Tiong and Russell, 1990, Huang et al., 2002)
visible | dominant | homeotic
(Brizuela and Kennison, 1997, Zorin et al., 1999, Kehle et al., 1998)
visible | homeotic
(Milne et al., 1999)
hide Phenotype Manifest In
abdominal segment
(Milne et al., 1999)
anaphase | embryonic stage
(O'Dor et al., 2006)
leg
(Huang et al., 2002)
mesothoracic leg
(Brizuela and Kennison, 1997, Gutierrez et al., 2003, Harding et al., 1995, Tiong and Russell, 1990, Kehle et al., 1998)
mesothoracic leg & sex comb | ectopic
(Zorin et al., 1999)
mesothoracic leg & sex comb tooth | ectopic
(Ragab, 2006)
metathoracic leg
(Brizuela and Kennison, 1997, Gutierrez et al., 2003, Harding et al., 1995, Tiong and Russell, 1990, Kehle et al., 1998)
metathoracic leg & sex comb | ectopic
(Zorin et al., 1999)
metathoracic leg & sex comb tooth | ectopic
(Ragab, 2006)
sex comb
(Milne et al., 1999, Kehle et al., 1998)
sex comb (with Df(3R)ry27)
(Wang and Brock, 2003)
sex comb (with Df(3R)ry619)
(Wang and Brock, 2003)
sex comb | ectopic
(Gutierrez et al., 2003, Zorin et al., 1999, Schulze et al., 2001, Chang et al., 2001, Huang et al., 2002)
sex comb | supernumerary
(Brown and Kassis, 2010)
telophase | embryonic stage
(O'Dor et al., 2006)
wing
(Tiong and Russell, 1990)
hide Detailed Description
Statement
Reference
Pc4 embryos from hetrozygous mothers show segregation defects in anaphase and telophase as judged by the presence of chromatin bridges. Most of these chromatin bridges are probably resolved because large irregularly-shaped nuclei and polyploid nuclei are only seen at a low penetrance. Pc4 embryos also show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. Fallout nuclei tend to be observed in pairs or clusters and have a late telophase appearance. There is no evidence of metaphase defects in these embryos.
(O'Dor et al., 2006)
Pc4 males have ectopic sex combs on the second and third leg.
(Ragab, 2006)
93% of heterozygous males have sex comb teeth on the second and/or third leg. Expressivity of the phenotype is 14%.
(Gutierrez et al., 2003)
Pc4/+ heterozygotes exhibit a wild-type number of sex combs, with 2 legs exhibiting sex combs. Pc4/Df(3R)ry27 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 2.7 legs with sex combs, compared to 2.1 in Pc4/+ heterozygotes. Pc4/Df(3R)ry619 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 2.9 legs with sex combs, compared to 2.3 in Pc4/Tp(3;3)MRS heterozygotes.
(Wang and Brock, 2003)
Heterozygous males have ectopic sex combs on the second and third legs.
(Huang et al., 2002)
An average of about 1 ectopic sex comb teeth are seen per leg in Pc4 mutant animals.
(Chang et al., 2001)
Approximately 57% of heterozygous males have ectopic sex combs on the second and/or third legs, indicating a transformation towards first leg.
(Zorin et al., 1999)
The extra sex combs phenotype of Pc4 is dominantly enhanced by E(Pc)1 and E(Pc)2. The extra sex combs phenotype is also very weakly enhanced by E(Pc)rv4, E(Pc)rv9 and E(Pc)rv10.
(Sinclair et al., 1998)
Heterozygous adults have sex comb teeth on the second and third legs. The penetrance of this phenotype is 100% and the expressivity is 25%.
(Brizuela and Kennison, 1997)
Mutation has no effect on the hhMrt wing phenotype.
(Felsenfeld and Kennison, 1995)
Partial transformation of T2 and T3 legs toward T1.
(Harding et al., 1995)
Embryonic lethal or semi-lethal when heterozygous with ph-d2. Unhatched larvae carry segmentation defects or polarity defects.
(McKeon et al., 1994)
Heterozygous adults show transformations of 3rd and 2nd leg to 1st leg, wing to haltere, and ventral wing margin to dorsal wing margin.
(Tiong and Russell, 1990)
Haplo-abnormal phenotype is suppressed by a duplication carrying Pc.
(Kennison and Russell, 1987)
partial transformations of second and third legs into first legs in Pc/+ heterozygotes
 
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hideEnhanced by
Statement
Reference
Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-2[+]/Mi-26
(Kehle et al., 1998)
Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-2[+]/Mi-2j3D4
(Kehle et al., 1998)
Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-21/Mi-2[+]
(Kehle et al., 1998)
Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-24/Mi-2[+]
(Kehle et al., 1998)
Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-25/Mi-2[+]
(Kehle et al., 1998)
Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-27/Mi-2[+]
(Kehle et al., 1998)
Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-28/Mi-2[+]
(Kehle et al., 1998)
Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-29/Mi-2[+]
(Kehle et al., 1998)
Pc4 has visible | dominant | homeotic phenotype, enhanceable by Mi-2K1/Mi-2[+]
(Kehle et al., 1998)
Pc4 has visible | dominant | homeotic phenotype, enhanceable by Pcl10/Pcl[+]
(Kehle et al., 1998)
Pc4 has visible | dominant phenotype, enhanceable by E(Pc)1
(Sinclair et al., 1998)
Pc4 has visible | dominant phenotype, enhanceable by E(Pc)2
(Sinclair et al., 1998)
Pc4 has visible | dominant phenotype, enhanceable by E(Pc)rv4
(Sinclair et al., 1998)
Pc4 has visible | dominant phenotype, enhanceable by E(Pc)rv9
(Sinclair et al., 1998)
Pc4 has visible | dominant phenotype, enhanceable by E(Pc)rv10
(Sinclair et al., 1998)
Pc4 has visible | dominant phenotype, enhanceable by psq[+]/psq0115
(Huang et al., 2002)
Pc4 has visible | dominant phenotype, enhanceable by psq[+]/psq02403
(Huang et al., 2002)
Pc4 has visible | dominant phenotype, enhanceable by psq[+]/psqE34
(Huang et al., 2002)
Pc4 has visible | dominant phenotype, enhanceable by psq[+]/psqF112
(Huang et al., 2002)
Pc4 has visible | dominant phenotype, enhanceable by psq8109/psq[+]
(Huang et al., 2002)
Pc4 has visible | dominant phenotype, enhanceable by psqE39/psq[+]
(Huang et al., 2002)
Pc4 has visible | dominant phenotype, enhanceable by psqΔ18/psq[+]
(Huang et al., 2002)
hideSuppressed by
Statement
Reference
Pc4 has visible | dominant | adult stage phenotype, suppressible by mor1
(Brizuela and Kennison, 1997)
Pc4 has visible | dominant | adult stage phenotype, suppressible by mor2
(Brizuela and Kennison, 1997)
Pc4 has visible | dominant | adult stage phenotype, suppressible by mor4
(Brizuela and Kennison, 1997)
Pc4 has visible | dominant | homeotic phenotype, suppressible by lawcp1
(Zorin et al., 1999)
Pc4 has visible | dominant | homeotic phenotype, suppressible by mor1
(Brizuela and Kennison, 1997)
Pc4 has visible | dominant | homeotic phenotype, suppressible by mor2
(Brizuela and Kennison, 1997)
Pc4 has visible | dominant | homeotic phenotype, suppressible by mor4
(Brizuela and Kennison, 1997)
Pc4 has visible | dominant phenotype, suppressible | partially by tna1
(Gutierrez et al., 2003)
Pc4 has visible phenotype, suppressible by l(3)80Fj2-30
(Schulze et al., 2001)
Pc4 has visible phenotype, suppressible by vtd2
(Schulze et al., 2001)
Pc4 has visible phenotype, suppressible by vtd3
(Schulze et al., 2001)
Pc4 has visible phenotype, suppressible by vtd4
(Schulze et al., 2001)
Pc4 has visible phenotype, suppressible by vtd7
(Schulze et al., 2001)
Pc4 has visible phenotype, suppressible by vtd8
(Schulze et al., 2001)
Pc4 has visible phenotype, suppressible by vtd9
(Schulze et al., 2001)
Pc4 has visible phenotype, suppressible by vtd10
(Schulze et al., 2001)
hideNOT suppressed by
Statement
Reference
Pc4 has visible phenotype, non-suppressible by vtd11
(Schulze et al., 2001)
Pc4 has visible phenotype, non-suppressible by vtd12
(Schulze et al., 2001)
hideNOT Suppressor of
Statement
Reference
Pc4 is a non-suppressor of lethal phenotype of Ras85DV12.sev, sevS11.T:Hsap\MYC
(Maixner et al., 1998)
hide Phenotype Manifest In
hideEnhanced by
Statement
Reference
Pc4 has abdominal segment phenotype, enhanceable by Asx3
(Milne et al., 1999)
Pc4 has abdominal segment phenotype, enhanceable by AsxP1
(Milne et al., 1999)
Pc4 has leg phenotype, enhanceable by E(Pc)1
(Sinclair et al., 1998)
Pc4 has leg phenotype, enhanceable by E(Pc)2
(Sinclair et al., 1998)
Pc4 has leg phenotype, enhanceable by E(Pc)rv4
(Sinclair et al., 1998)
Pc4 has leg phenotype, enhanceable by E(Pc)rv9
(Sinclair et al., 1998)
Pc4 has leg phenotype, enhanceable by E(Pc)rv10
(Sinclair et al., 1998)
Pc4 has leg phenotype, enhanceable by psq[+]/psq0115
(Huang et al., 2002)
Pc4 has leg phenotype, enhanceable by psq[+]/psq02403
(Huang et al., 2002)
Pc4 has leg phenotype, enhanceable by psq[+]/psqE34
(Huang et al., 2002)
Pc4 has leg phenotype, enhanceable by psq[+]/psqF112
(Huang et al., 2002)
Pc4 has leg phenotype, enhanceable by psq8109/psq[+]
(Huang et al., 2002)
Pc4 has leg phenotype, enhanceable by psqE39/psq[+]
(Huang et al., 2002)
Pc4 has leg phenotype, enhanceable by psqΔ18/psq[+]
(Huang et al., 2002)
Pc4 has mesothoracic leg phenotype, enhanceable by Mi-2[+]/Mi-26
(Kehle et al., 1998)
Pc4 has mesothoracic leg phenotype, enhanceable by Mi-2[+]/Mi-2j3D4
(Kehle et al., 1998)
Pc4 has mesothoracic leg phenotype, enhanceable by Mi-21/Mi-2[+]
(Kehle et al., 1998)
Pc4 has mesothoracic leg phenotype, enhanceable by Mi-24/Mi-2[+]
(Kehle et al., 1998)
Pc4 has mesothoracic leg phenotype, enhanceable by Mi-25/Mi-2[+]
(Kehle et al., 1998)
Pc4 has mesothoracic leg phenotype, enhanceable by Mi-27/Mi-2[+]
(Kehle et al., 1998)
Pc4 has mesothoracic leg phenotype, enhanceable by Mi-28/Mi-2[+]
(Kehle et al., 1998)
Pc4 has mesothoracic leg phenotype, enhanceable by Mi-29/Mi-2[+]
(Kehle et al., 1998)
Pc4 has mesothoracic leg phenotype, enhanceable by Mi-2K1/Mi-2[+]
(Kehle et al., 1998)
Pc4 has mesothoracic leg phenotype, enhanceable by Pcl10/Pcl[+]
(Kehle et al., 1998)
Pc4 has metathoracic leg phenotype, enhanceable by Mi-2[+]/Mi-26
(Kehle et al., 1998)
Pc4 has metathoracic leg phenotype, enhanceable by Mi-2[+]/Mi-2j3D4
(Kehle et al., 1998)
Pc4 has metathoracic leg phenotype, enhanceable by Mi-21/Mi-2[+]
(Kehle et al., 1998)
Pc4 has metathoracic leg phenotype, enhanceable by Mi-24/Mi-2[+]
(Kehle et al., 1998)
Pc4 has metathoracic leg phenotype, enhanceable by Mi-25/Mi-2[+]
(Kehle et al., 1998)
Pc4 has metathoracic leg phenotype, enhanceable by Mi-27/Mi-2[+]
(Kehle et al., 1998)
Pc4 has metathoracic leg phenotype, enhanceable by Mi-28/Mi-2[+]
(Kehle et al., 1998)
Pc4 has metathoracic leg phenotype, enhanceable by Mi-29/Mi-2[+]
(Kehle et al., 1998)
Pc4 has metathoracic leg phenotype, enhanceable by Mi-2K1/Mi-2[+]
(Kehle et al., 1998)
Pc4 has metathoracic leg phenotype, enhanceable by Pcl10/Pcl[+]
(Kehle et al., 1998)
Pc4 has phenotype, enhanceable by Df(2R)trix/+
(Milne et al., 1999)
Pc4 has phenotype, enhanceable by Pcl18
(Kennison and Tamkun, 1988)
Pc4 has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)1
(Sinclair et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)2
(Sinclair et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)rv4
(Sinclair et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)rv9
(Sinclair et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by E(Pc)rv10/E(Pc)[+]
(Sinclair et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-2[+]/Mi-26
(Kehle et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-2[+]/Mi-2j3D4
(Kehle et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-21/Mi-2[+]
(Kehle et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-24/Mi-2[+]
(Kehle et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-25/Mi-2[+]
(Kehle et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-27/Mi-2[+]
(Kehle et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-28/Mi-2[+]
(Kehle et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-29/Mi-2[+]
(Kehle et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by Mi-2K1/Mi-2[+]
(Kehle et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by Pcl10/Pcl[+]
(Kehle et al., 1998)
Pc4 has sex comb | ectopic phenotype, enhanceable by psq[+]/psq0115
(Huang et al., 2002)
Pc4 has sex comb | ectopic phenotype, enhanceable by psq[+]/psq02403
(Huang et al., 2002)
Pc4 has sex comb | ectopic phenotype, enhanceable by psq[+]/psqE34
(Huang et al., 2002)
Pc4 has sex comb | ectopic phenotype, enhanceable by psq[+]/psqF112
(Huang et al., 2002)
Pc4 has sex comb | ectopic phenotype, enhanceable by psq8109/psq[+]
(Huang et al., 2002)
Pc4 has sex comb | ectopic phenotype, enhanceable by psqE39/psq[+]
(Huang et al., 2002)
Pc4 has sex comb | ectopic phenotype, enhanceable by psqΔ18/psq[+]
(Huang et al., 2002)
Pc4 has sex comb phenotype, enhanceable by Asx1
(Milne et al., 1999)
Pc4 has sex comb phenotype, enhanceable by Asx3
(Milne et al., 1999)
Pc4 has sex comb phenotype, enhanceable by Asx8
(Milne et al., 1999)
Pc4 has sex comb phenotype, enhanceable by Asx9
(Milne et al., 1999)
Pc4 has sex comb phenotype, enhanceable by Asx13
(Milne et al., 1999)
Pc4 has sex comb phenotype, enhanceable by AsxP1
(Milne et al., 1999)
Pc4 has sex comb phenotype, enhanceable by Df(3L)10H
(Chang et al., 2001)
Pc4 has sex comb phenotype, enhanceable by Hsc70-4195/Hsc70-4[+]
(Wang and Brock, 2003)
Pc4 has sex comb phenotype, enhanceable by Rpd3303
(Chang et al., 2001)
Pc4 has sex comb phenotype, enhanceable by Rpd3313
(Chang et al., 2001)
Pc4 has sex comb phenotype, enhanceable by Rpd304556
(Chang et al., 2001)
Pc4 has sex comb phenotype, enhanceable by Rpd3def8
(Chang et al., 2001)
hideNOT Enhanced by
Statement
Reference
Pc4 has mesothoracic leg phenotype, non-enhanceable by Deaf1k3
(Veraksa et al., 2002)
Pc4 has mesothoracic leg phenotype, non-enhanceable by Deaf1S10B
(Veraksa et al., 2002)
Pc4 has sex comb | ectopic phenotype, non-enhanceable by Deaf1k3
(Veraksa et al., 2002)
Pc4 has sex comb | ectopic phenotype, non-enhanceable by Deaf1S10B
(Veraksa et al., 2002)
Pc4 has sex comb | supernumerary phenotype, non-enhanceable by Spps1/Spps1
(Brown and Kassis, 2010)
hideSuppressed by
Statement
Reference
Pc4 has mesothoracic leg phenotype, suppressible | partially by tna1
(Gutierrez et al., 2003)
Pc4 has mesothoracic leg phenotype, suppressible by lawcp1
(Zorin et al., 1999)
Pc4 has mesothoracic leg phenotype, suppressible by mor1
(Brizuela and Kennison, 1997)
Pc4 has mesothoracic leg phenotype, suppressible by mor2
(Brizuela and Kennison, 1997)
Pc4 has mesothoracic leg phenotype, suppressible by mor4
(Brizuela and Kennison, 1997)
Pc4 has metathoracic leg phenotype, suppressible | partially by tna1
(Gutierrez et al., 2003)
Pc4 has metathoracic leg phenotype, suppressible by mor1
(Brizuela and Kennison, 1997)
Pc4 has metathoracic leg phenotype, suppressible by mor2
(Brizuela and Kennison, 1997)
Pc4 has metathoracic leg phenotype, suppressible by mor4
(Brizuela and Kennison, 1997)
Pc4 has phenotype, suppressible | partially by Nipped-B29/Nipped-B[+]
(Hallson et al., 2008)
Pc4 has phenotype, suppressible by brm2
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by brm3
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by brm4
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by brm5
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by brm6
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by btldev1
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by btldev2
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by Dll12
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by kis1
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by kis2
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by kis3
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by kis4
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by kis5
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by kis6
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by kis7
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by kis8
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by kis9
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by kto1
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by mor3
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by mor4
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by mor5
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by mor6
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by osa1
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by osa2
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by osa3
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by osa4
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by ScrE1
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by ScrE2
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by ScrE3
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by ScrE4
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by skd1
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by skd2
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by sls1
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by Su(Pc)37D1
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxB14
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxE1
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxE2
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxE4
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxE5
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxE6
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxE7
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxE8
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxE9
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxE10
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxE11
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by trxE13
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by urd1
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by urd2
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by Vha5515
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by Vha5516
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by vtd1
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by vtd2
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by vtd3
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by vtd4
(Kennison and Tamkun, 1988)
Pc4 has phenotype, suppressible by vtd5
(Kennison and Tamkun, 1988)
Pc4 has prothoracic leg phenotype, suppressible by lawcp1
(Zorin et al., 1999)
Pc4 has sex comb | ectopic phenotype, suppressible | partially by tna1
(Gutierrez et al., 2003)
Pc4 has sex comb | ectopic phenotype, suppressible by l(3)80Fj2-30
(Schulze et al., 2001)
Pc4 has sex comb | ectopic phenotype, suppressible by vtd2
(Schulze et al., 2001)
Pc4 has sex comb | ectopic phenotype, suppressible by vtd3
(Schulze et al., 2001)
Pc4 has sex comb | ectopic phenotype, suppressible by vtd4
(Schulze et al., 2001)
Pc4 has sex comb | ectopic phenotype, suppressible by vtd7
(Schulze et al., 2001)
Pc4 has sex comb | ectopic phenotype, suppressible by vtd8
(Schulze et al., 2001)
Pc4 has sex comb | ectopic phenotype, suppressible by vtd9
(Schulze et al., 2001)
Pc4 has sex comb | ectopic phenotype, suppressible by vtd10
(Schulze et al., 2001)
Pc4 has sex comb phenotype, suppressible by mor1
(Brizuela and Kennison, 1997)
Pc4 has sex comb phenotype, suppressible by mor2
(Brizuela and Kennison, 1997)
Pc4 has sex comb phenotype, suppressible by mor4
(Brizuela and Kennison, 1997)
Pc4 has sex comb phenotype, suppressible by Rpd3326
(Chang et al., 2001)
Pc4 has sex comb phenotype, suppressible by vtd4
(Strübbe et al., 2011)
Pc4 has sex comb phenotype, suppressible by vtdex3
(Strübbe et al., 2011)
hideNOT suppressed by
Statement
Reference
Pc4 has mesothoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921
(Ragab, 2006)
Pc4 has mesothoracic leg phenotype, non-suppressible by Deaf1k3
(Veraksa et al., 2002)
Pc4 has mesothoracic leg phenotype, non-suppressible by Deaf1S10B
(Veraksa et al., 2002)
Pc4 has metathoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921
(Ragab, 2006)
Pc4 has phenotype, non-suppressible by lawc+10
(Zorin et al., 1999)
Pc4 has sex comb | ectopic phenotype, non-suppressible by Deaf1k3
(Veraksa et al., 2002)
Pc4 has sex comb | ectopic phenotype, non-suppressible by Deaf1S10B
(Veraksa et al., 2002)
Pc4 has sex comb | ectopic phenotype, non-suppressible by vtd11
(Schulze et al., 2001)
Pc4 has sex comb | ectopic phenotype, non-suppressible by vtd12
(Schulze et al., 2001)
hideEnhancer of
Statement
Reference
Pc4 is an enhancer of wing vein L3 phenotype of rhove-1
(Marenda et al., 2004)
hideNOT Enhancer of
Statement
Reference
Pc4 is a non-enhancer of sex comb phenotype of Scr2
(Southworth and Kennison, 2002)
hideSuppressor of
Statement
Reference
Pc4 is a suppressor | partially of eye phenotype of CycEJP
(Brumby et al., 2002)
hideNOT Suppressor of
Statement
Reference
Pc4 is a non-suppressor of sex comb phenotype of Scr2
(Southworth and Kennison, 2002)
hideOther
Statement
Reference
Df(2R)trix, Pc4 has adult prothoracic segment phenotype
(Milne et al., 1999)
Pc[+]/Pc4, Pcl18 has sex comb phenotype
(Kennison and Tamkun, 1988)
Pc[+]/Pc4, ScmK1 has sex comb phenotype
(Kennison and Tamkun, 1988)
Pc4, brm2 has wing vein L3 phenotype
(Marenda et al., 2004, Marenda et al., 2004)
Pc4, Snr1E1 has wing phenotype
(Marenda et al., 2004, Marenda et al., 2004)
Pc4, Snr1E1 has wing vein L3 phenotype
(Marenda et al., 2004, Marenda et al., 2004)
Pc4, Snr1E1 has wing vein L4 phenotype
(Marenda et al., 2004, Marenda et al., 2004)
Pc4, Snr1E1 has wing vein L5 phenotype
(Marenda et al., 2004, Marenda et al., 2004)
hide Additional Comments
hide Genetic Interactions
Statement
Reference
Df(2R)ED3921 fails to suppress the ectopic sex comb phenotype of Pc4 mutants.
(Ragab, 2006)
Pc4/Snr1E1 animals have incomplete L3, L4 and L5 wing veins (9%, 42% and 37% respectively) and moderate curling and disruption of the wing along the posterior wing margin. Pc4/brm2 animals have an incomplete L3 wing vein (15%).
(Marenda et al., 2004)
Pc4/Hsc70-4195 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 2.4 legs with sex combs, compared to 2.0 in wild-type.
(Wang and Brock, 2003)
Mutant weakly suppresses the CycEJP rough eye phenotype.
(Brumby et al., 2002)
The ectopic sex comb phenotype seen on the second and third legs of Pc[4]/+ males is dominantly enhanced by psq[0115], psq[02403], psq[8109], psq[Δ18], psq[F112], psq[E34] or psq[E39].
(Huang et al., 2002)
The average number of sex comb teeth per first leg Scr2/+ males is not affected if they are also carrying Pc4. The average number of sex comb teeth per first leg Df(3R)Scr/+ males is not affected if they are also carrying Pc4.
(Southworth and Kennison, 2002)
Deaf1k3 or Deaf1S10B do not change the number of ectopic sex combs in the T2 legs of Pc4 males.
(Veraksa et al., 2002)
The addition of Df(3L)10H, Rpd304556, Rpd3303, Rpd3313 or Rpd3def8 to Pc4 animals more than doubles the average number of ectopic sex comb teeth seen per leg. The addition of Rpd3326 to Pc4 animals partially suppresses the ectopic sex comb teeth phenotype.
(Chang et al., 2001)
AsxP1 strongly enhances the extra sex combs phenotype and abdominal homeotic transformations associated with Pc4. Pc4/+, Df(2R)trix/+ show a darkly pigmented outgrowth from the first thoracic segment, corresponding to a strong posterior transformation of the prothorax to mesothorax.
(Milne et al., 1999)
The leg transformation phenotype of Pc4/+ males is largely suppressed by lawcp1.
(Zorin et al., 1999)
The formation of extra sex combs on the second and third legs in Pc4/+ flies is dominantly enhanced by Mi-2K1, Mi-21, Mi-2j3D4, Mi-24, Mi-25, Mi-26, Mi-27, Mi-28, Mi-29 or Pcl10. The formation of extra sex combs on the second and third legs in Pc4/+ flies is not enhanced by Trl62, Trl3 or Trls2325.
(Kehle et al., 1998)
The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is not suppressed by Pc4.
(Maixner et al., 1998)
The penetrance and expressivity of the Pc4/+ transformation phenotype is dominantly suppressed by mor1, mor2 or mor4.
(Brizuela and Kennison, 1997)
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Comments
hide Stocks ( 0 )
hide Notes on Origin
Discoverer
Russell.
hide Comments
The penetrance for the Scr derepression phenotype in Pc4 heterozygotes is 100%.
(Tamkun et al., 1992)
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym
Pc4
(Huang et al., 2002, O'Dor et al., 2006, Wang and Brock, 2003, Hallson et al., 2008, Brown and Kassis, 2010, Strübbe et al., 2011)
PcR1
(Fuse et al., 1999, Tiong and Russell, 1990, Kennison and Tamkun, 1988, Kennison and Russell, 1987, Riley et al., 1987, )
Name Synonym
Secondary FlyBase IDs
hide References ( 37 )
Generate a list of
List References by type
hide Recent research papers ( 1 )
Strübbe et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(14): 5572--5577
Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners. [FBrf0213360]
Show all research papers ...