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General Information
Symbol
Dmel\Pc11
Species
D. melanogaster
Name
FlyBase ID
FBal0013561
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
PcXL5
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Pc11 is a two amino acid deletion at amino acids 69 and 70 within the chromo domain.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Two amino acid deletion at amino acids 69 and 70 within the chromo domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Pc11 heterozygous males show a highly prevalent ectopic sex comb phenotype.

Heterozygous males have an extra sex comb phenotype that is more pronounced at 29[o]C than at 25[o]C.

Pc11/+ suppresses the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5, P{hsp26-pt-T}39C-27, P{hsp26-pt-T}39C-31 and P{wA}4-4.

Heterozygotes show transformation of second and third legs to first leg, resulting in extra sex combs. Most heterozygotes have normal wings and very few show a mild transformation of the wing to haltere.

Partial transformations of second and third legs into first legs in Pc/+ heterozygotes.

Very strong haploinsufficient Pc phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference

Pc11 has homeotic | adult stage phenotype, suppressible | partially by enok1/enok[+]

Pc11 has homeotic | adult stage phenotype, suppressible | partially by enok[+]/enok2

Pc11 has visible | dominant | heat sensitive phenotype, suppressible by Hsp83[+]/Hsp83e6A

Pc11 has visible | dominant | homeotic phenotype, suppressible by Dsp11

Enhancer of
Statement
Reference

Pc11 is an enhancer of visible | dominant | homeotic phenotype of AntpD43

Suppressor of
Statement
Reference

Pc[+]/Pc11 is a suppressor of visible | homeotic phenotype of Dsp11

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

Pc11 has phenotype, enhanceable by Sam-S1

Pc11 has phenotype, enhanceable by Sam-SM6

Suppressed by
Statement
Reference

Pc11 has sex comb | ectopic phenotype, suppressible | partially by enok1/enok[+]

Pc11 has sex comb | ectopic phenotype, suppressible | partially by enok[+]/enok2

Pc11 has sex comb | ectopic | heat sensitive phenotype, suppressible by Hsp83[+]/Hsp83e6A

Pc11 has mesothoracic leg phenotype, suppressible by Dsp11

Pc11 has metathoracic leg phenotype, suppressible by Dsp11

Pc11 has sex comb | ectopic phenotype, suppressible by Dsp11

Pc11 has sex comb | ectopic phenotype, suppressible by Vha55j2E9/Vha55[+]

Enhancer of
Statement
Reference

Pc11 is an enhancer of antenna phenotype of AntpD43

Pc11 is an enhancer of leg | ectopic phenotype of AntpD43

Suppressor of
Statement
Reference

Pc11 is a suppressor of wing phenotype of sdFab-X

Pc[+]/Pc11 is a suppressor of sex comb phenotype of Dsp11

Other
Statement
Reference

Pc[+]/Pc11, rept06945 has mesothoracic leg & sex comb | ectopic phenotype

Pc[+]/Pc11, rept06945 has metathoracic leg & sex comb | ectopic phenotype

MRG15j6A3, Pc[+]/Pc11 has mesothoracic leg & sex comb | ectopic phenotype

MRG15j6A3, Pc[+]/Pc11 has metathoracic leg & sex comb | ectopic phenotype

Additional Comments
Genetic Interactions
Statement
Reference

Heterozygosity for Hsp83e6A suppresses the extra sex comb phenotype of Pc11/+ males at both 25[o]C and 29[o]C.

rept06945 Pc11 double heterozygous males have ectopic sex combs on the second and third legs (47% and 5% of flies respectively).

MRG15j6A3 Pc11 double heterozygous males have ectopic sex combs on the second and third legs (85% and 54% of flies respectively).

MRG15ex1 shows no interaction (in terms of ectopic sex comb phenotype) when in double heterozygous combination with Pc11.

Approximately 100% of AntpD43/Pc11 animals show transformation of antenna into leg. The number of T2 and T3 legs with sex combs is reduced in Dsp11/Y ; Pc11/+ flies compared to Pc11/+ single mutants. The size of the sex comb on the first leg is almost normal in Dsp11/Y ; Pc11/+ flies. The majority of Pc11/+ heterozygotes in which Dsp1Scer\UAS.cDa is expressed under the control of Scer\GAL4hs.PB show a mild transformation of the wing to haltere and there is a considerable increase in the number of T3 legs with a sex comb.

Vha55j2E9 dominantly suppresses the ectopic sex comb phenotype of Pc11 mutant males.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (21)