Open Close
General Information
Symbol
Dmel\Pcl11
Species
D. melanogaster
Name
FlyBase ID
FBal0013618
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
PclW4
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Heterozygotes show a significant increase in double strand break (DSB) repair via homologous recombination and a corresponding decrease in DSB repair by nonhomologous end-joining compared to controls in a somatic DSB repair assay, when whd-y+ is used as the recipient allele bearing the target break site.
17% of heterozygous males have ectopic sex combs on the second leg.
17-20% of T2 legs and 0% of T3 legs have sex combs in heterozygous males.
Heterozygous males sometimes have ectopic sex combs on the second and third legs.
Mutation does not affect the level of w expression in ph-plac+3 flies.
Mutation has no effect on the hhMrt wing phenotype.
Transformation of legs 2 and 3 to leg 1.
Haplo-abnormal phenotype is suppressed by a duplication carrying Pc.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Pcl11 has visible | dominant phenotype, enhanceable by rept[+]/rept06945
Pcl11 has visible | dominant | homeotic phenotype, enhanceable by Sirt117/Sir2[+]
Pcl11 has visible | dominant | homeotic phenotype, enhanceable by Sir2[+]/Sirt12A-7-11
Pcl11 has visible | dominant phenotype, enhanceable by corto[+]/corto420
Enhancer of
Statement
Reference
Pcl[+]/Pcl11 is an enhancer of visible | adult stage | temperature conditional phenotype of crm32
Suppressor of
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
Pcl11 has mesothoracic leg & sex comb | ectopic phenotype, enhanceable by rept[+]/rept06945
Pcl11 has mesothoracic leg phenotype, enhanceable by Sirt117/Sir2[+]
Pcl11 has sex comb | ectopic phenotype, enhanceable by Sirt117/Sir2[+]
Pcl11 has mesothoracic leg phenotype, enhanceable by Sir2[+]/Sirt12A-7-11
Pcl11 has sex comb | ectopic phenotype, enhanceable by Sir2[+]/Sirt12A-7-11
Pcl11 has phenotype, enhanceable by E(Pc)1
Enhancer of
Statement
Reference
Pcl[+]/Pcl11 is an enhancer of sex comb | supernumerary | temperature conditional phenotype of crm32
NOT Enhancer of
Statement
Reference
Pcl[+]/Pcl11 is a non-enhancer of wing vein | ectopic phenotype of Snr1E1
Pcl11 is a non-enhancer of eye phenotype of CycEJP
Suppressor of
NOT Suppressor of
Statement
Reference
Pcl[+]/Pcl11 is a non-suppressor of wing vein | ectopic phenotype of Snr1E1
Pcl11 is a non-suppressor of eye phenotype of CycEJP
Pcl11 is a non-suppressor of phenotype of w4.Ubx.bxd:pbx.ΔBC3
Other
Statement
Reference
Pcl11, rept[+]/rept06945 has metathoracic leg & sex comb | ectopic phenotype
Additional Comments
Genetic Interactions
Statement
Reference
The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is ameliorated by combination with a single copy of Pcl11.
A Pcl11/+ background enhances the ectopic posterior sex comb phenotype seen in crm32 homozygotes.
47% of rept06945/+ ; Pcl11/+ males have ectopic sex combs on the second leg and 4% have ectopic sex combs on the third leg.
The frequency of ectopic sex combs seen in Pcl11/+ males is increased by Sir22A-7-11; in Sir22A-7-11/+ ; Pcl11/+ double heterozygous males, 76% of T2 legs and 35% of T3 legs have sex combs. The frequency of ectopic sex combs seen in Pcl11/+ males is increased by Sir217; in Sir217/+ ; Pcl11/+ double heterozygous males, 71% of T2 legs and 38% of T3 legs have sex combs.
The ectopic sex comb phenotype seen on the second and third legs of Pcl11/+ males is enhanced by corto420/+.
Xenogenetic Interactions
Statement
Reference
The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is ameliorated by combination with a single copy of Pcl11.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (18)