A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\pcx1

General Information
SymbolDmel\pcx1SpeciesD. melanogaster
NameFlyBase IDFBal0013627
Feature typealleleAssociated geneDmel\pcx
Allele class
Mutagenethyl methanesulfonate
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Description
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hide Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(LaBonne and Furst, 1989)
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
 
 
Cytology
hide Phenotypic Data
hide Phenotypic Class
lethal | maternal effect
(Lindsley and Zimm, 1992)
hide Phenotype Manifest In
embryonic/first instar larval cuticle | ventral
(Lindsley and Zimm, 1992)
presumptive embryonic/larval central nervous system
(Lindsley and Zimm, 1992)
hide Detailed Description
Statement
Reference
No effect on the faf eye phenotype.
(Huang and Fischer-Vize, 1996)
Homozygous mutant females crossed to mutant males produce lethal embryos showing hypertrophy of the central nervous system at the expense of the epidermis, a small patch of dorsal cuticle remaining but no ventral cuticle. This embryonic phenotype (as well as the reduced eye phenotype of viable pcx adults) resembles that of amx.
(Lindsley and Zimm, 1992)
Homozygous early gastrula embryos derived from homozygous females give rise to a greater than wild-type number of neurons in culture.
(LaBonne and Furst, 1989)
Homozygous pcx lethal embryos can be partially rescued almost up to hatching by preblastoderm microinjection of wild-type or amx ooplasm.
(LaBonne and Mahowald, 1985)
Germ line clonal analysis demonstrates the germ-line dependency of the pcx embryonic lethal phenotype.
(Perrimon et al., 1984)
Homozygous pcx lethal embryos can be rescued genetically; some mutant females (but not pcx1 homozygotes) crossed to wild-type males produce viable adult pcx/+ female offspring the pcx/Y male offspring are lethal. pcx/+ heterozygous females, which are fertile, crossed to viable pcx/Y males (also fertile) produce viable adult males (pcx/Y and +/Y) and viable adult females (pcx/pcx and pcx/+).
(Romans et al., 1976)
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Statement
Reference
hide Xenogenetic Interactions
Statement
Reference
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Comments
hide Stocks ( 0 )
hide Notes on Origin
Discoverer
Romans.
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Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym
mel(1)R1o
(Lindsley and Zimm, 1992)
pcx1
 
Name Synonym
Secondary FlyBase IDs
hide References ( 6 )
Research paper
Huang and Fischer-Vize, 1996, Development 122(10): 3207--3216
Undifferentiated cells in the developing Drosophila eye influence facet assembly and require the Fat facets ubiquitin-specific protease. [FBrf0090618]
LaBonne and Furst, 1989, J. Neurogenet. 5: 99--104
Differentiation in vitro of neural precursor cells from normal and Pecanex mutant Drosophila embryos. [FBrf0050371]
LaBonne and Mahowald, 1985, Dev. Biol. 110: 264--267
Partial rescue of embryos from two maternal-effect neurogenic mutants by transplantation of wild-type ooplasm. [FBrf0042361]
Perrimon et al., 1984, Genetics 108: 559--572
Developmental genetics of the 2E-F region of the Drosophila X chromosome: a region rich in 'developmentally important' genes. [FBrf0040957]
Romans et al., 1976, Canad. J. Genet. Cytol. 18: 773--781
Maternally influenced embryonic lethality: allele specific genetic rescue at a female fertility locus in Drosophila melanogaster. [FBrf0028476]
Book
Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.
The Genome of Drosophila melanogaster. [FBrf0066905]