Allele Dmel\ph-d⁵⁰³

General Information
Symbol	Dmel\ph-d⁵⁰³	Species	D. melanogaster
Name		FlyBase ID	FBal0013757
Feature type	allele	Associated gene	Dmel\ph-d

Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Dura et al., 1987, Cheng et al., 1994, Gindhart and Kaufman, 1995)
Mutagen	ethyl methanesulfonate (Dura et al., 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	ph-d²⁰⁹
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal (Cheng et al., 1994) lethal \| embryonic stage (Dura et al., 1987)
Phenotype Manifest In
	nuclear chromosome (Lupo et al., 2001)
Detailed Description
	Statement Reference Over 50% of mutant embryos in anaphase, show multiple chromosomal bridges and in some cases have chromosomal breaks. (Lupo et al., 2001)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference ph-d[+]/ph-d⁵⁰³ is a suppressor of visible \| dominant \| homeotic phenotype of ash1¹⁷, trx^B11/trx[+] (Gildea et al., 2000) ph-d[+]/ph-d⁵⁰³ is a suppressor of visible \| dominant \| homeotic phenotype of brm[+]/brm², trx^E2 (Gildea et al., 2000) ph-d⁵⁰³ is a suppressor of eye color defective phenotype of w^T81 (Netter et al., 1998)
Phenotype Manifest In
NOT Enhancer of
Statement Reference ph-d⁵⁰³ is a non-enhancer of eye phenotype of CycE^JP (Brumby et al., 2002)
Suppressor of
Statement Reference ph-d[+]/ph-d⁵⁰³ is a suppressor of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+] (Gildea et al., 2000) ph-d[+]/ph-d⁵⁰³ is a suppressor of adult metathoracic segment phenotype of brm[+]/brm², trx^E2 (Gildea et al., 2000)
NOT Suppressor of
Statement Reference ph-d⁵⁰³ is a non-suppressor of eye phenotype of CycE^JP (Brumby et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference Strong suppressor of eye pigment phenotype of w^T81. (Netter et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	1411 y¹ ph-d⁵⁰³ w¹ f^36a/FM7c, sn⁺/Dp(1;2;Y)w⁺
Kyoto	106304 y¹ ph-d⁵⁰³ w¹ f^36a/FM7c/Dp(1;2;Y)w⁺
Notes on Origin
Discoverer

Comments
	Shows no significant dominant suppression of the nos mutant phenotype. (Pelegri and Lehmann, 1994) Weak derepression of en expression. (Moazed and O'Farrell, 1992)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	ph⁵⁰³ (Lupo et al., 2001, Rusch and Kaufman, 2000, Netter et al., 1998, Gindhart and Kaufman, 1995, McKeon et al., 1994, Pelegri and Lehmann, 1994, Simon et al., 1993, Dura et al., 1987, O'Dor et al., 2006) ph^d503 (Gildea et al., 2000) ph-d⁵⁰³ (Popodi, 2010.10.8)
Name Synonym
Secondary FlyBase IDs

References ( 15 )
Research paper	O'Dor et al., 2006, Dev. Biol. 290(2): 312--322 Polycomb Group mutants exhibit mitotic defects in syncytial cell cycles of Drosophila embryos. [FBrf0190149] Brumby et al., 2002, EMBO J. 21(13): 3377--3389 Drosophila cyclin E interacts with components of the Brahma complex. [FBrf0151282] Lupo et al., 2001, Molec. Cell 7(1): 127--136 Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing. [FBrf0134762] Gildea et al., 2000, Genetics 156(2): 645--663 A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. [FBrf0129826] Rusch and Kaufman, 2000, Genetics 156(1): 183--194 Regulation of proboscipedia in Drosophila by homeotic selector genes. [FBrf0130058] Netter et al., 1998, Genetics 149(1): 257--275 white+ transgene insertions presenting a dorsal/ventral pattern define a single cluster of homeobox genes that is silenced by the polycomb-group proteins in Drosophila melanogaster. [FBrf0102846] Gindhart and Kaufman, 1995, Genetics 139(2): 797--814 Identification of Polycomb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene sex combs reduced. [FBrf0080053] Cheng et al., 1994, Genetics 138(4): 1151--1162 Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogaster. [FBrf0078203] McKeon et al., 1994, Molec. gen. Genet. 244(5): 474--483 Mutations in some Polycomb group genes of Drosophila interfere with regulation of segmentation genes. [FBrf0076960] Pelegri and Lehmann, 1994, Genetics 136(4): 1341--1353 A role of Polycomb group genes in the regulation of gap gene expression in Drosophila. [FBrf0074146] Simon et al., 1993, Dev. Biol. 158(1): 131--144 Elements of the Drosophila Bithorax complex that mediate repression by Polycomb group products. [FBrf0058048] Moazed and O'Farrell, 1992, Development 116(3): 805--810 Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. [FBrf0055896] McKeon and Brock, 1991, Roux Arch. dev. Biol. 199(7): 387--396 Interactions of the Polycomb group of genes with homeotic loci of Drosophila. [FBrf0055050] Dura et al., 1987, Cell 51: 829--839 A complex genetic locus, polyhomeotic, is required for segmental specification and epidermal development in Drosophila melanogaster. [FBrf0045782]
Personal communication to FlyBase	Popodi, 2010.10.8, Additional data for selected DC Duplications. Additional data for selected DC Duplications. [FBrf0212038]

Allele Dmel\ph-d503

Allele Dmel\ph-d⁵⁰³