FlyBase Allele Report: Dmel\pll[2]

General Information

Symbol

Dmel\pll²

Species

D. melanogaster

Name

FlyBase ID

FBal0013856

Feature type

allele

Associated gene

Dmel\pll

Associated Insertion(s)

Carried in Construct

Also Known As

pll⁰⁷⁸, pll⁷⁸

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Shelton and Wasserman, 1993)

Mutagen

ethyl methanesulfonate

(Hecht and Anderson, 1993, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Amino acid replacement: G225E.

(Towb et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:27,252,226..27,252,226 [-]

Nucleotide change:

G27252226A

Amino acid change:

G225E | pll-PA; G225E | pll-PB

Reported amino acid change:

G225E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Towb et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with pll⁷)

(Minidorff et al., 2007)

lethal | maternal effect | recessive

(Hecht and Anderson, 1993)

Phenotype Manifest In

axon & eye photoreceptor cell (with pll⁷)

(Minidorff et al., 2007)

embryonic/larval hemolymph (with pll¹⁰)

(Qiu et al., 1998)

hemocyte | larval stage (with pll¹⁰)

(Qiu et al., 1998)

lamina (with pll⁷)

(Minidorff et al., 2007)

medulla (with pll⁷)

(Minidorff et al., 2007)

Detailed Description

Statement

Reference

pll⁷/pll² larvae show show mistargeting of the R2-R5 photoreceptor axons in the developing visual system; thickened bundles of axons along the entire length of the lamina are observed to penetrate into the medulla, while the lamina is not smooth and is somewhat irregular.

(Minidorff et al., 2007)

The ability of pll⁷/pll² larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.

(Sorrentino et al., 2004)

Shows brain tumours when heterozygous with the MBT chromosome. Pupal lethal when heterozygous with the MBT chromosome.

(Riede, 2001)

Hemocyte density in the hemolymph of pll¹⁰/pll² larvae is significantly lower than in the hemolymph of control larvae.

(Qiu et al., 1998)

Level of Drs induction of bacterially challenged pll²/pll²¹ and pll²/pll¹⁰ mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate. Infection of pll²/pll²¹ mutants with A.fumigatus causes 4% survival 3 days postinfection, infection with E.coli causes 87% survival 3 days postinfection.

(Lemaitre et al., 1996)

Injection of the pll::tor^t4021p construct into pll¹⁰/pll² and pll¹⁰/Df(3R)D605 heterozygotes causes the induction of dorsoventral pattern elements, the tor::tub^t4021t construct cannot induce dorsoventral pattern elements.

(Großhans et al., 1994)

Homozygotes and heterozygotes with pll² produce strongly dorsalised embryos. Heterozygotes with pll¹ produce strongly dorsalised embryos.

(Hecht and Anderson, 1993)

Injected dl^- perivitelline fluid had no effect on embryos.

(Stein and Nusslein-Volhard, 1992)

Embryos derived from pll²/pll¹⁰ females are completely dorsalised. At the late cellular blastoderm stage, all the cells have rounded apical surfaces and the nuclei are located apically.

(Leptin and Grunewald, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

btx^P, pll² has lethal | pupal stage phenotype

(Riede, 2001)

efe⁸⁹, pll² has lethal | pupal stage phenotype