Allele Dmel\pll²

General Information
Symbol	Dmel\pll²	Species	D. melanogaster
Name		FlyBase ID	FBal0013856
Feature type	allele	Associated gene	Dmel\pll
Also Known As	pll⁰⁷⁸, pll⁷⁸

Map ( GBrowse )
Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Shelton and Wasserman, 1993)
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987, Hecht and Anderson, 1993)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:23,077,948..23,077,948 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=G23077948A pr_change=G225E\|pll-PA reported_pr_change=G225E (Towb et al., 2001)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: G225E. (Towb et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| maternal effect \| recessive (Hecht and Anderson, 1993) neuroanatomy defective (with pll⁷) (Minidorff et al., 2007)
Phenotype Manifest In
	axon & eye photoreceptor cell (with pll⁷) (Minidorff et al., 2007) embryonic/larval hemolymph (with pll¹⁰) (Qiu et al., 1998) hemocyte \| larval stage (with pll¹⁰) (Qiu et al., 1998) lamina (with pll⁷) (Minidorff et al., 2007) medulla (with pll⁷) (Minidorff et al., 2007)
Detailed Description
	Statement Reference pll[7]/pll[2] larvae show show mistargeting of the R2-R5 photoreceptor axons in the developing visual system; thickened bundles of axons along the entire length of the lamina are observed to penetrate into the medulla, while the lamina is not smooth and is somewhat irregular. (Minidorff et al., 2007) The ability of pll⁷/pll² larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae. (Sorrentino et al., 2004) Shows brain tumours when heterozygous with the MBT chromosome. Pupal lethal when heterozygous with the MBT chromosome. (Riede, 2001) Hemocyte density in the hemolymph of pll¹⁰/pll² larvae is significantly lower than in the hemolymph of control larvae. (Qiu et al., 1998) Level of Drs induction of bacterially challenged pll²/pll²¹ and pll²/pll¹⁰ mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate. Infection of pll²/pll²¹ mutants with A.fumigatus causes 4% survival 3 days postinfection, infection with E.coli causes 87% survival 3 days postinfection. (Lemaitre et al., 1996) Injection of the pll::tor^t4021p construct into pll¹⁰/pll² and pll¹⁰/Df(3R)D605 heterozygotes causes the induction of dorsoventral pattern elements, the tor::tub^t4021t construct cannot induce dorsoventral pattern elements. (Grosshans et al., 1994) Homozygotes and heterozygotes with pll² produce strongly dorsalised embryos. Heterozygotes with pll¹ produce strongly dorsalised embryos. (Hecht and Anderson, 1993) Injected dl^- perivitelline fluid had no effect on embryos. (Stein and Nusslein-Volhard, 1992) Embryos derived from pll²/pll¹⁰ females are completely dorsalised. At the late cellular blastoderm stage, all the cells have rounded apical surfaces and the nuclei are located apically. (Leptin and Grunewald, 1990)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference btx^P, pll² has lethal \| pupal stage phenotype (Riede, 2001, Riede, 2001) Df(3R)mbt^P, pll² has lethal \| pupal stage phenotype (Riede, 2001) efe⁸⁹, pll² has lethal \| pupal stage phenotype (Riede, 2001, Riede, 2001) mer-on-3¹⁴, pll² has lethal \| pupal stage phenotype (Riede, 2001, Riede, 2001) pll², rigel^P has lethal \| larval stage phenotype (Riede, 2001, Riede, 2001) pll², srn⁸⁸ has lethal \| pupal stage phenotype (Riede, 2001, Riede, 2001) pll², tld⁶ has lethal \| pupal stage phenotype (Riede, 2001, Riede, 2001)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference spz³/pll² does not result in neoplasms. (Riede, 2001)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	3111 e¹ pll² ca¹/TM3, Sb¹
Kyoto	106852 e¹ pll² ca¹/TM3, Sb¹
Notes on Origin
Discoverer

Comments
	Strong pll allele. (Hecht and Anderson, 1993)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	pll² (Christensen et al., 2008.4.15, Minidorff et al., 2007, Cook et al., 2009.2.28, Habayeb et al., 2009) pll⁰⁷⁸ (Sorrentino et al., 2004, Riede, 2001, Towb et al., 2001, Qiu et al., 1998, Levashina et al., 1998, Nicolas et al., 1998, Edwards et al., 1997, Yip et al., 1997, Bergmann et al., 1996, Lemaitre et al., 1996, Lemaitre et al., 1995, Grosshans et al., 1994, Morisato and Anderson, 1994, Hecht and Anderson, 1993, Stein and Nusslein-Volhard, 1992, Roth et al., 1991, Stein et al., 1991, Leptin and Grunewald, 1990, Tearle and Nusslein-Volhard, 1987, Tauszig-Delamasure et al., 2002) pll⁷⁸ (De Gregorio et al., 2002, Shelton and Wasserman, 1993)
Name Synonym
Secondary FlyBase IDs

References ( 29 )

Generate a list of	All references relating to this allele ( 29 )

List References by type	Research paper ( 26 ) Personal communication to FlyBase ( 2 ) Stock list ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...

Allele Dmel\pll2

Allele Dmel\pll²