|Feature type||allele||Associated gene||Dmel\pll|
|Also Known As||pll078, pll78|
|Map ( GBrowse )|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: G225E.
|Phenotype Manifest In|
pll/pll larvae show show mistargeting of the R2-R5 photoreceptor axons in the developing visual system; thickened bundles of axons along the entire length of the lamina are observed to penetrate into the medulla, while the lamina is not smooth and is somewhat irregular.
The ability of pll7/pll2 larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.
Shows brain tumours when heterozygous with the MBT chromosome. Pupal lethal when heterozygous with the MBT chromosome.
Hemocyte density in the hemolymph of pll10/pll2 larvae is significantly lower than in the hemolymph of control larvae.
Level of Drs induction of bacterially challenged pll2/pll21 and pll2/pll10 mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate. Infection of pll2/pll21 mutants with A.fumigatus causes 4% survival 3 days postinfection, infection with E.coli causes 87% survival 3 days postinfection.
Injection of the pll::tort4021p construct into pll10/pll2 and pll10/Df(3R)D605 heterozygotes causes the induction of dorsoventral pattern elements, the tor::tubt4021t construct cannot induce dorsoventral pattern elements.
Homozygotes and heterozygotes with pll2 produce strongly dorsalised embryos. Heterozygotes with pll1 produce strongly dorsalised embryos.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
(Sorrentino et al., 2004, Riede, 2001, Towb et al., 2001, Qiu et al., 1998, Levashina et al., 1998, Nicolas et al., 1998, Edwards et al., 1997, Yip et al., 1997, Bergmann et al., 1996, Lemaitre et al., 1996, Lemaitre et al., 1995, Grosshans et al., 1994, Morisato and Anderson, 1994, Hecht and Anderson, 1993, Stein and Nusslein-Volhard, 1992, Roth et al., 1991, Stein et al., 1991, Leptin and Grunewald, 1990, Tearle and Nusslein-Volhard, 1987, Tauszig-Delamasure et al., 2002)
|Secondary FlyBase IDs|
|References ( 29 )|
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|Recent research papers (0)|
|All research papers listed in FlyBase were published before 2011|