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General Information
Symbol
Dmel\pll2
Species
D. melanogaster
Name
FlyBase ID
FBal0013856
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
pll078, pll78
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G27252226A

Amino acid change:

G225E | pll-PA; G225E | pll-PB

Reported amino acid change:

G225E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: G225E.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

pll7/pll2 larvae show show mistargeting of the R2-R5 photoreceptor axons in the developing visual system; thickened bundles of axons along the entire length of the lamina are observed to penetrate into the medulla, while the lamina is not smooth and is somewhat irregular.

The ability of pll7/pll2 larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.

Shows brain tumours when heterozygous with the MBT chromosome. Pupal lethal when heterozygous with the MBT chromosome.

Hemocyte density in the hemolymph of pll10/pll2 larvae is significantly lower than in the hemolymph of control larvae.

Level of Drs induction of bacterially challenged pll2/pll21 and pll2/pll10 mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate. Infection of pll2/pll21 mutants with A.fumigatus causes 4% survival 3 days postinfection, infection with E.coli causes 87% survival 3 days postinfection.

Injection of the pll::tort4021p construct into pll10/pll2 and pll10/Df(3R)D605 heterozygotes causes the induction of dorsoventral pattern elements, the tor::tubt4021t construct cannot induce dorsoventral pattern elements.

Homozygotes and heterozygotes with pll2 produce strongly dorsalised embryos. Heterozygotes with pll1 produce strongly dorsalised embryos.

Injected dl- perivitelline fluid had no effect on embryos.

Embryos derived from pll2/pll10 females are completely dorsalised. At the late cellular blastoderm stage, all the cells have rounded apical surfaces and the nuclei are located apically.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

spz3/pll2 does not result in neoplasms.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (30)