|Feature type||allele||Associated gene||Dmel\pnr|
|Also Known As||pnr7G|
|Map ( GBrowse )|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Nucleotide substitution: G1034A. Amino acid replacement: W180@.
Molecular lesion unknown.
|Phenotype Manifest In|
Heterozygous adults show an increase in heart arrest/fibrillation compared to control flies upon electrical pacing of the heart. The severity of the defect increases with age. Heterozygous adults show an increase in irregular heart rate compared to controls. The mean diastolic interval length is increased compared to controls.
Single cell class IV dendrite arborisation (da) neuron clones that are homozygous for pnr do not show defects in the establishment or maintenance of dendritic tiling.
In pnr1 mutant embryos, the number of cardioblasts is strongly reduced and the embryos fail to form a closed heart tube.
In mutant embryos most cardioblasts so not develop, although short stretches of cardioblast still arise. A strong decrease in pericardial cells is also seen.
Homozygous embryos have a severe dorsal hole. Cardial cells are absent, and there is an excess of eve-expressing pericardial cells.
Homozygous embryos show bunching of epidermal segments at the end of dorsal closure.
Homozygotes exhibit a dorsal hole that is broader than that of pnrVX6 or Df(3R)sbd45 homozygotes. Heterozygotes with pnrD3 give adult escapers and heterozygotes with pnrVX5 show extra dorsocentrals. Mitotic clones in the thorax adjacent to the thoracic midline cause a sizeable bilateral cleft involving most of the scutum causing the entire scutellum to disappear.
embryonic lethal. Dorsal anterior of embryo open.
|Phenotype Manifest In|
|NOT Enhanced by|
|NOT suppressed by|
Expression of XNP[UY3132] under the control of Scer\GAL4[455.2] enhances the penetrance of the scutellar phenotypes seen in pnr heterozygotes.
The increase in heart arrest/fibrillation upon electrical pacing that is seen in pnr/+ adults is not significantly altered by tin/+ or Df(3R)GC14/+. The increase in heart arrest/fibrillation upon electrical pacing that is seen in pnr/+ adults is not significantly altered by H15[nmr-614]/+ or Df(2L)Exel6012/+.
|Complementation & Rescue Data|
|Partially rescued by|
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 4 )|
|Secondary FlyBase IDs|
|References ( 13 )|